Cited by 1,201Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

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The role of STATs in transcriptional control and their impact on cellular function

Bromberg, Jacqueline, Darnell, James E·2000·Oncogene

DOI 10.1038/sj.onc.1203476

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Abstract

The STAT proteins (Signal Transducers and Activators of Transcription), were identified in the last decade as transcription factors which were critical in mediating virtually all cytokine driven signaling. These proteins are latent in the cytoplasm and become activated through tyrosine phosphorylation which typically occurs through cytokine receptor associated kinases (JAKs) or growth factor receptor tyrosine kinases. Recently a number of non-receptor tyrosine kinases (for example src and abl) have been found to cause STAT phosphorylation. Phosphorylated STATs form homo- or hetero-dimers, enter the nucleus and working coordinately with other transcriptional co-activators or transcription factors lead to increased transcriptional initiation. In normal cells and in animals, ligand dependent activation of the STATs is a transient process, lasting for several minutes to several hours. In contrast, in many cancerous cell lines and tumors, where growth factor dysregulation is frequently at the heart of cellular transformation, the STAT proteins (in particular Stats 1, 3 and 5) are persistently tyrosine phosphorylated or activated. The importance of STAT activation to growth control in experiments using anti-sense molecules or dominant negative STAT protein encoding constructs performed in cell lines or studies in animals lacking specific STATs strongly indicate that STATs play an important role in controlling cell cycle progression and apoptosis. Stat1 plays an important role in growth arrest, in promoting apoptosis and is implicated as a tumor suppressor; while Stats 3 and 5 are involved in promoting cell cycle progression and cellular transformation and preventing apoptosis. Many questions remain including: (1) a better understanding of how the STAT proteins through association with other factors increase transcription initiation; (2) a more complete definition of the sets of genes which are activated by different STATs and (3) how these sets of activated genes differ as a function of cell type. Finally, in the context of many cancers, where STATs are frequently persistently activated, an understanding of the mechanisms leading to their constitutive activation and defining the potential importance of persistent STAT activation in human tumorigenesis remains. Oncogene (2000).

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Self-citation
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
A Matter of Life and Cell Death
Evan, G. I., & Littlewood, T. D. (1998) · Science · doi:10.1126/science.281.5381.1317 · Cited by 1,528
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465

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Finan, R. R., Mustafa, F. E., Al-Zaman, I., Madan, S., Issa, A. A., & Almawi, W. Y. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00765.x · Cited by 18
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Jeon, Y. J., Jung, S., Chang, H., Yun, J., Lee, C. W., Lee, J., Choi, S., Nash, O., Han, D. C., & Kwon, B. (2015) · Phytotherapy Research · doi:10.1002/ptr.5311 · Cited by 19
Tumor-Induced Immune Suppression
Gabrilovich, D. I., & Hurwitz, A. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-69118-3 · Cited by 18
Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon‐γ‐STAT1‐mediated killing
Hbibi, A. T., Laguillier, C., Souissi, I., Lesage, D., Coquil, S. L., Cao, A., Metelev, V., Baran‐Marszak, F., & Fagard, R. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06975.x · Cited by 18
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Lu, J., Power, C., Blevins, G., Giuliani, F., & Yong, V. W. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000011 · Cited by 18
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Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes
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Resistance to fludarabine-induced apoptosis in Epstein-Barr virus infected B cells
Fagard, R., Mouas, H., Dusanter‐Fourt, I., Devillers, C., Bissières, P., Martin, A., Lenoir, G., Tan, H. V., Feuillard, J., & Raphaël, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205554 · Cited by 18
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Hambek, M., Baghi, M., Strebhardt, K., Strebhard, K., May, A., Adunka, O. F., Gstöttner, W., & Knecht, R. (2004) · PubMed · Cited by 17
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Retracted
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Successful simultaneous measurement of cell membrane and cytokine induced phosphorylation pathways [CIPP] in human peripheral blood mononuclear cells
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STAT1, STAT3 and p38MAPK are involved in the apoptotic effect induced by a chimeric cyclic interferon-α2b peptide
Blank, V. C., Peña, C., & Roguin, L. P. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.11.016 · Cited by 13
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Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-β1 and IL-6
Ruff, K., Puetter, A., & Levy, L. S. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-35 · Cited by 12
Methylprednisolone induces apoptosis by interacting with the JAK/STAT pathway in HL-60 and K-562 leukemic cells
Kaymaz, B. T., Selvi, N., Saydam, G., Şahin, F., & Kosova, B. (2012) · Hematology · doi:10.1179/102453312x13221316477859 · Cited by 12
Systems analysis of protein signatures predicting cetuximab responses in KRAS , NRAS , BRAF and PIK3CA wild‐type patient‐derived xenograft models of metastatic colorectal cancer
Lindner, A. U., Carberry, S., Monsefi, N., Barat, A., Salvucci, M., O’Byrne, R., Zanella, E. R., Cremona, M., Hennessy, B. T., Bertotti, A., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33226 · Cited by 12
Role of crosstalk between STAT3 and mTOR signaling in driving sensitivity to chemotherapy in osteosarcoma cell lines
Wang, Y., Tang, F., Hu, X., Zheng, C., Gong, T., Zhou, Y., Luo, Y., & Min, L. (2020) · IUBMB Life · doi:10.1002/iub.2349 · Cited by 12
Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes.
Song, L.-N., Cao, X., Ji, W.-Y., Zhao, L., Yang, W., Lu, M., & Yang, J.-K. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175040 · Cited by 8
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Zhang, Z., & Zhu, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512494 · Cited by 13
Gold nanoparticle-based beacon to detect STAT5b mRNA expression in living cells: a case optimized by bioinformatics screen
Deng, D., Gu, Y., Yang, L., Xue, J., Wang, J., Ai, G., & Li, X. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s81754 · Cited by 12
SR16388: a steroidal antiangiogenic agent with potent inhibitory effect on tumor growth in vivo
Chao, W.-R., Amin, K., Shi, Y. H., Hobbs, P. D., Tanabe, M., Tanga, M. J., Jong, L., Collins, N., Peters, R. H., Laderoute, K. R., et al. (2010) · Angiogenesis · doi:10.1007/s10456-010-9191-z · Cited by 12
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Wei, X., Cheng, X., Peng, Y., Zheng, R., Chai, J., & Jiang, S. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.06.003 · Cited by 12
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Gammaherpesviruses of New World primates
Fleckenstein, B., & Ensser, A. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545313.061 · Cited by 12

Authors: Bromberg, J., & Darnell, J. E.
Affiliations: Rockefeller University (US)
ORCID: Bromberg, Jacqueline
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2468-2473
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203476
OpenAlex: W1977681992
Cited by: 1,201
References: 66
Citations by year: 2026: 10 · 2025: 22 · 2024: 21 · 2023: 24 · 2022: 37 · 2021: 40 · 2020: 46 · 2019: 41 · 2018: 42 · 2017: 51 · 2016: 46 · 2015: 49 · 2014: 59 · 2013: 67 · 2012: 56
FWCI: 6.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT proteins, transcriptional regulation, cytokine signaling, JAK kinases, tyrosine phosphorylation, STAT1, STAT3, STAT5, cell cycle progression, apoptosis, tumor suppressor, cell transformation, carcinogenesis, transcriptional coactivator
MeSH terms: Animals, Cell Division, Cell Transformation, Neoplastic, DNA-Binding Proteins, Gene Expression Regulation, Humans, Milk Proteins, Neoplasms, Structure-Activity Relationship, Transcription, Genetic, Trans-Activators, STAT1 Transcription Factor, STAT3 Transcription Factor, STAT5 Transcription Factor

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The role of STATs in transcriptional control and their impact on cellular function

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