The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription
Abstract
Recent advances in the field of in vitro chromatin assembly have led to in vitro transcription systems which reproduce in the test tube, in vivo characteristics of ligand-dependent transcriptional activation by nuclear receptors. Dissection of these systems has begun to provide us with information concerning the underlying molecular mechanisms. Through recruitment of coactivator proteins, nuclear receptors act first to remodel chromatin within the promoter region and then to recruit the transcriptional machinery to the promoter region in order to initiate transcription. Here we present a possible sequential mechanism for ligand-dependent transcriptional activation by nuclear receptors and discuss the in vitro and in vivo data that support this model.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the absence of ligand, transcription is turned “off” by RXR/RAR heterodimers bound to DNA and associated to corepressor complexes”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the citing paper
“According to the current model of gene regulation by RARs ( 89 ), in the absence of ligand, the DNA-bound RAR ␣ subtype is associated with corepressors, which serve as adaptors recruiting high molecular weight complexes endowed with histone deacetylase (HDAC) activity ( 90 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the citing paper
“These complexes deacetylate lysine residues in the N-terminal tails of histones and maintain chromatin in a condensed, repressed state over the target promoter ( 35, 89 ) ( Fig. 4A ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the citing paper
“Then, activated RARs recruit the transcription machinery, including the multisubunit Mediator complex, RNA polymerase II, and the general transcription factors ( 35, 89 ) ( Fig. 4B ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
Citations
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 3×
“Comparison of the primary structure between these proteins revealed that all three NR types share a highly conserved domain structure (reviewed in Chambon, 1996; Evans, 1988; Green and Chambon, 1988).”
BackgroundSelf-citationShiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,759
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S. A., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,398
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
The CBP co-activator is a histone acetyltransferase
Bannister, A. J., & Kouzarides, T. (1996) · Nature · doi:10.1038/384641a0 · Cited by 1,828
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–272 of 272
Messier, T., Boyd, J. R., Gordon, J. A. R., Tye, C. E., Page, N. A., Toor, R. H., Zaidi, S. K., Komm, B. S., Frietze, S. E., Stein, J. L., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271725 · Cited by 10
Suzuki, S., Liu, J., Sato, Y. A., Miyake, R., Suzuki, S., Okitsu, Y., Fukuda, T., Isaji, T., Gu, J., & Takahashi, S. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149541 · Cited by 9
Expression and regulation of aldehyde dehydrogenases in prostate cancer
Ibrahim, A. I. M., Sadiq, M., Frame, F. M., Maitland, N. J., & Pors, K. (2018) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2018.07 · Cited by 9
Yin, H., Glass, J., & Blanchard, K. L. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-51 · Cited by 9
Of Meis and men: Lessons from a microarray study of teratogen action
Docterman, K. E., & Smith, S. M. (2002) · Teratology · doi:10.1002/tera.10110 · Cited by 9
Short circuit: Transcription factor addiction as a growing vulnerability in cancer
Davies, M., Boyce, M., & Conway, E. (2024) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2024.102948 · Cited by 10
The role of phytoandrogens for benign prostatic hyperplasia treatment
Wu, Y., Wichai, N., Yang, X., Ma, Y., Suo, T., & Miao, L. (2023) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000055 · Cited by 7
Poirier, M.-B., Hamann, G., Domingue, M.-È., Roy, M., Bardati, T., & Langlois, M. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0449 · Cited by 7
Kislat, A., Oláh, P., Kuchner, M., Gerber, P. A., Schrader, J., Meller, S., & Homey, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119654 · Cited by 6
Russo, L., Sladitschek, H. L., & Neveu, P. A. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.014 · Cited by 6
Dahiya, N. R., Leibovitch, B. A., Kadamb, R., Bansal, N., & Waxman, S. (2022) · Cells · doi:10.3390/cells11071179 · Cited by 6
Thyroid Hormone Receptors, Coregulators, and Disease
Privalsky, M. L. (2008) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812819178_0006 · Cited by 6
Isolation and characterization of axolotl NPDC-1 and its effects on retinoic acid receptor signaling
Theodosiou, M., Monaghan, J. R., Spencer, M. L., Voss, S. R., & Noonan, D. J. (2007) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2007.01.008 · Cited by 4
Bläse, M., Santo-Hoeltje, L., & Rodemann, H. P. (2003) · Strahlentherapie und Onkologie · doi:10.1007/s00066-003-1030-3 · Cited by 3
Long, W., & O’Malley, B. W. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-8039-6_1 · Cited by 2
Ni, S., Liu, J., Huang, X., Wang, W., Huang, Y., & Qin, Q. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.03.046 · Cited by 2
Abboud, J. M., Koppel, I. A., Uggerud, E., Leito, I., Koppel, I., Sekiguchi, O., Kaupmees, K., Saame, J., Kütt, K., & Mishima, M. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201500717 · Cited by 2
A potential influence of vitamin D on HIV infection and bone disease in HIV-positive patients
Misiorowski, W. (2013) · HIV & AIDS Review · doi:10.1016/j.hivar.2013.09.001 · Cited by 2
Wu, N., Li, R., Meng, Z., Nie, M., Chen, Q., He, B., Deng, Z., & Yin, L. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3910 · Cited by 2
Huwaimel, B., Abouzied, A. S., Emwas, A.-H. M., Ahmed, A. F., El‐Nagar, M. K. S., Mohammed, H. A., Alrashidi, N. M., Alrashidi, M. A., Alshammari, R. E., Albladi, A. Y., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108512 · Cited by 1
Epigenetic gene regulation and stem cell function
Benyoucef, A., & Brand, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799958-6.00007-x · Cited by 1
Baba, S. M., Azad, N. A., Shah, Z. A., Afroze, D., Pandith, A. A., Jan, A., Aziz, S. A., & Dar, F. A. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2016.17.4.1999 · Cited by 1
Methods to Study Dynamic Interaction of Androgen Receptor with Chromatin in Living Cells
Kirli, H. Z., & Saatcioglu, F. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-243-4_9 · Cited by 1
Gehring, U. (2004) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-004-1035-4 · Cited by 1
Signaling to Chromatin Minireview: Role of Kinases and Chromatin Remodeling in Progesterone
Vicent, G. P., Nacht, A. S., Zaurín, R., Ballaré, C., Clausell, J., & Beato, M. (2010) · Cited by 1
Hormonally Regulated Transcription Factors
Bolander, F. F. (2004) · Elsevier eBooks · doi:10.1016/b978-012111232-5/50013-0 · Cited by 1
Regulation of chaperone proteins in the retinoid pathway in human malignancies
Karaosmanoğlu, O. (2023) · Studies in natural products chemistry · doi:10.1016/b978-0-443-18961-6.00013-5 · Cited by 1
Control of Gene Expression by Nuclear Retinoic Acid Receptors
Carrier, M., & Rochette‐Egly, C. (2015) · doi:10.1002/9781118628003.ch5 · Cited by 1
Thépot, S., Adès, L., & Fenaux, P. (2011) · doi:10.1002/9781444394016.ch8 · Cited by 1
Lammi, J. (2008) · Työväentutkimus Vuosikirja · Cited by 1
Wu, N., Li, R., Meng, Z., Nie, M., Chen, Q., He, B., Deng, Z., & Yin, L. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4817 · Cited by 1
Kolluri, S. (2004) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/yyrz-qa79 · Cited by 1
Gene expression patterns in human prostate stem cell differentiation
Oldridge, E. E. (2012) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Novel Coactivators for Androgen Receptor
DeFranco, D. B. (2003) · doi:10.21236/ada415941
A REVIEW OF NUCLEAR RECEPTOR GENE ACTIVATION THROUGH COFACTOR PROTEIN INTERACTIONS
Baker, R. L. (2008) · KU ScholarWorks (The University of Kansas)
Retinoic acid metabolism blocking agents (RAMBAS) in hyperkeratotic disorders
Verfaille, C. J. (2007) · doi:10.26481/dis.20070427cv
Sessler, R. J. (2005) · eCommons (Cornell University)
Transcriptional Regulation: Coordination
Egly, J., & Rochette‐Egly, C. (2005) · Wiley eBooks · doi:10.1038/npg.els.0005288
Role of PELP1 in EGFR-ER Signaling Crosstalk in Ovarian Cancer Cells
Vadlamudl, R. K. (2008) · doi:10.21236/ada509750
Molecular Mechanisms of Androgen Receptor Interactions
Thompson, J. S. (2006) · Työväentutkimus Vuosikirja
Hormonal interactions in progesterone regulation of gonadotropin gene expression
Ghochani, Y. (2009) · eScholarship (California Digital Library)
Bu, P. (2009) · KU ScholarWorks (The University of Kansas)
Characterization of Alien isoforms in vertebrates
Renkawitz, R., Biologie, F., Gießen, J.-L.-U., & Terol, A. M. (2002)
Modulation of folate receptor-α by glucocorticoid receptor and progesterone receptor.
Tran, T. (2005) · Europe PMC (PubMed Central)
Salazar, M. D. (2010) · OhioLink ETD Center (Ohio Library and Information Network)
The Biology behind Gene Expression: A Basic Tutorial
Ochs, M. F., & Golemis, E. A. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48354-8_2
Aldhamen, Y. A. (2007) · OhioLink ETD Center (Ohio Library and Information Network)
Cras, A., Guidez, F., & Chomienne, C. (2010) · Springer eBooks · doi:10.1007/978-90-481-3303-1_9
Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells
Chen, C.-C. (2009) · OakTrust (Texas A&M University Libraries)
Milton, F. A. (2015) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2015.02.t.18077
Genomic Approaches to Understanding Vitamin D Action
Fleet, J. C. (2004) · Nutrition and disease prevention · doi:10.1201/9780203025925.ch9
Identifizierung und Charakterisierung von Interaktionspartnern des Transkriptionsfaktors AATF
Mathematisch-naturwissenschaftlichen Fakultät, I., & Friedrich-Wilhelms-Universität, R. (2003)
Higazi, A. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4521
Co-activators and Corepressors for the Nuclear Receptor Superfamily
Rowan, B. G., & O’Malley, B. W. (2003) · Encyclopedia of Hormones · doi:10.1016/b0-12-341103-3/00276-x
Amer, D. A. M. (2011) · Qucosa (Saxon State and University Library Dresden)
Lacerda, M. G. (2016) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2016.12.t.23043
Leid, M. E. (2003) · Wiley eBooks · doi:10.1002/0471266949.bmc065
Epigenetic gene regulation in multiple myeloma and mood disorders
Kalushkova, A. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Epigenetic of Retinoic Acid Receptor β2 Gene in Breast Cancer
Mehdipour, P. (2015) · Springer eBooks · doi:10.1007/978-94-017-9639-2_11
Ontogénèse et régulation des aquaporines par les rétinoïdes dans les membranes foetales humaines
Prat, C. (2012) · theses.fr (ABES) · doi:10.70675/9b77e7a6za81fz410azb360zf93e79717d06
Involvement of TFIIH in NER factors mediated chromatin remodeling
Singh, A. (2014) · theses.fr (ABES) · doi:10.70675/9a7cf956z3bdaz44c5za560za206d78e4cea
Dynamique de la chromatine et la régulation du changement du type sexuel chez la levure
Audibert, S. (2017) · theses.fr (ABES) · doi:10.70675/f66e3ffdz145az4ef9zad03za7eed8d99cce
The vitamin rheostat: A unified model of epigenetic feedback in vitamin homeostasis
Kubant, R., Anderson, G. H., & Korda, M. (2026) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2026.195164
Săsăran, M. O., & Bănescu, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1905972
BindingDB Entry 50008667: Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins.
BindingDB (2021) · UC San Diego · doi:10.7270/q2pn990h
Metadata
- Authors
- Dilworth, F. J., & Chambon, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Oncogene
- Published
- 2001-05-28
- Volume
- 20
- Issue
- 24
- Pages
- 3047-3054
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2315037039
- Cited by
- 269
- References
- 83
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 10
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- nuclear receptors, chromatin remodeling, transcriptional coactivator, transcription initiation, in vitro transcription system, chromatin assembly
- MeSH terms
- Animals, Chromatin, Humans, Models, Biological, Transcription, Genetic, Trans-Activators, Receptors, Cytoplasmic and Nuclear
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review