The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription
Abstract
Recent advances in the field of in vitro chromatin assembly have led to in vitro transcription systems which reproduce in the test tube, in vivo characteristics of ligand-dependent transcriptional activation by nuclear receptors. Dissection of these systems has begun to provide us with information concerning the underlying molecular mechanisms. Through recruitment of coactivator proteins, nuclear receptors act first to remodel chromatin within the promoter region and then to recruit the transcriptional machinery to the promoter region in order to initiate transcription. Here we present a possible sequential mechanism for ligand-dependent transcriptional activation by nuclear receptors and discuss the in vitro and in vivo data that support this model.
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“In the absence of ligand, transcription is turned “off” by RXR/RAR heterodimers bound to DNA and associated to corepressor complexes”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the citing paper
“According to the current model of gene regulation by RARs ( 89 ), in the absence of ligand, the DNA-bound RAR ␣ subtype is associated with corepressors, which serve as adaptors recruiting high molecular weight complexes endowed with histone deacetylase (HDAC) activity ( 90 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the citing paper
“These complexes deacetylate lysine residues in the N-terminal tails of histones and maintain chromatin in a condensed, repressed state over the target promoter ( 35, 89 ) ( Fig. 4A ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the citing paper
“Then, activated RARs recruit the transcription machinery, including the multisubunit Mediator complex, RNA polymerase II, and the general transcription factors ( 35, 89 ) ( Fig. 4B ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
Citations
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 3×
“Comparison of the primary structure between these proteins revealed that all three NR types share a highly conserved domain structure (reviewed in Chambon, 1996; Evans, 1988; Green and Chambon, 1988).”
BackgroundSelf-citationShiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,759
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S. A., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,398
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
The CBP co-activator is a histone acetyltransferase
Bannister, A. J., & Kouzarides, T. (1996) · Nature · doi:10.1038/384641a0 · Cited by 1,828
Cited by
Sorted by citations
Nuclear retinoid receptors and the transcription of retinoid-target genes
Bastien, J., & Rochette-Egly, C. (2004) · Gene · doi:10.1016/j.gene.2003.12.005 · Cited by 773
Nakamura, T., Mori, T., Tada, S., Krajewski, W. A., Rozovskaia, T., Wassell, R. P., DuBois, G. C., Mazo, A., Croce, C. M., & Canaani, E. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00740-2 · Cited by 717
Perissi, V., Aggarwal, A. K., Glass, C. K., Rose, D. W., & Rosenfeld, M. G. (2004) · Cell · doi:10.1016/s0092-8674(04)00133-3 · Cited by 584
Controlling nuclear receptors: the circular logic of cofactor cycles
Perissi, V., & Rosenfeld, M. G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1680 · Cited by 507
The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1
Akashi, M., & Takumi, T. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb925 · Cited by 501
Metadata
- Authors
- Dilworth, F. J., & Chambon, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Oncogene
- Published
- 2001-05-28
- Volume
- 20
- Issue
- 24
- Pages
- 3047-3054
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2315037039
- Cited by
- 269
- References
- 83
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 10
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- nuclear receptors, chromatin remodeling, transcriptional coactivator, transcription initiation, in vitro transcription system, chromatin assembly
- MeSH terms
- Animals, Chromatin, Humans, Models, Biological, Transcription, Genetic, Trans-Activators, Receptors, Cytoplasmic and Nuclear
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