Cited by 272Genomics and Chromatin DynamicsChromatin Remodeling and CancerEstrogen and related hormone effects

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Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

Dilworth, F Jeffrey, Chambon, Pierre·2001·Oncogene

DOI 10.1038/sj.onc.1204329

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Abstract

Recent advances in the field of in vitro chromatin assembly have led to in vitro transcription systems which reproduce in the test tube, in vivo characteristics of ligand-dependent transcriptional activation by nuclear receptors. Dissection of these systems has begun to provide us with information concerning the underlying molecular mechanisms. Through recruitment of coactivator proteins, nuclear receptors act first to remodel chromatin within the promoter region and then to recruit the transcriptional machinery to the promoter region in order to initiate transcription. Here we present a possible sequential mechanism for ligand-dependent transcriptional activation by nuclear receptors and discuss the in vitro and in vivo data that support this model.

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Authors: Dilworth, F. J., & Chambon, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Dilworth, F Jeffrey
Chambon, Pierre
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2001-05-28
Volume: 20
Issue: 24
Pages: 3047-3054
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1204329
OpenAlex: W2315037039
Cited by: 269
References: 83
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 10
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: nuclear receptors, chromatin remodeling, transcriptional coactivator, transcription initiation, in vitro transcription system, chromatin assembly
MeSH terms: Animals, Chromatin, Humans, Models, Biological, Transcription, Genetic, Trans-Activators, Receptors, Cytoplasmic and Nuclear

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Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

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