Cited by 419Zebrafish Biomedical Research ApplicationsHematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

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The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis

Davidson, Alan J, Zon, Leonard I·2004·Oncogene

DOI 10.1038/sj.onc.1207943

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Abstract

Progressive advances using zebrafish as a model organism have provided hematologists with an additional genetic system to study blood cell formation and hematological malignancies. Despite extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways governing hematopoiesis have been highly conserved. As a result, most (if not all) of the critical hematopoietic transcription factor genes identified in mammals have orthologues in zebrafish. As in other vertebrates, all of the teleost blood lineages are believed to originate from a pool of pluripotent, self-renewing hematopoietic stem cells. Here, we provide a detailed review of the timing, anatomical location, and transcriptional regulation of zebrafish 'primitive' and 'definitive' hematopoiesis as well as discuss a model of T-cell leukemia and recent advances in blood cell transplantation. Given that many of the regulatory genes that control embryonic hematopoiesis have been implicated in oncogenic pathways in adults, an understanding of blood cell ontogeny is likely to provide insights into the pathophysiology of human leukemias.

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Authors: Davidson, A. J., & Zon, L. I.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Zon, Leonard I
ORCID: Davidson, Alan J
Zon, Leonard I
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2004-09-20
Volume: 23
Issue: 43
Pages: 7233-7246
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1207943
OpenAlex: W2032417286
Cited by: 419
References: 108
Citations by year: 2026: 8 · 2025: 11 · 2024: 19 · 2023: 12 · 2022: 21 · 2021: 18 · 2020: 18 · 2019: 20 · 2018: 25 · 2017: 24 · 2016: 26 · 2015: 16 · 2014: 25 · 2013: 17 · 2012: 21
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: definitive hematopoiesis, primitive hematopoiesis, hematopoietic stem cells, hematopoietic transcription factors, orthologs, T-cell leukemia, hematologic malignancies, leukemogenesis
MeSH terms: Animals, Blood Cells, Embryo, Nonmammalian, Forecasting, Gastrula, Genetic Complementation Test, Growth Substances, Hematopoiesis, Hematopoietic Stem Cells, Leukemia, Mesoderm, Radiation Chimera, Transcription Factors, Transcription, Genetic, Zebrafish, Mutagenesis, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Cell Lineage, Models, Animal, Zebrafish Proteins, Animals, Genetically Modified, Pluripotent Stem Cells

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The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis

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