Cited by 230Cytokine Signaling Pathways and InteractionsAngiogenesis and VEGF in CancerPleural and Pulmonary Diseases

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

Yeh, H-H, Lai, W-W, Chen, H H W, Liu, H-S, Su, W-C·2006·Oncogene

DOI 10.1038/sj.onc.1209464

Open this paper in CoChat — free account

Abstract

Malignant pleural effusion (MPE) is a poor prognostic sign for patients with non-small-cell lung cancer (NSCLC). The generation of MPE is largely regulated by vascular endothelial growth factor (VEGF), and upregulation of VEGF by Stat3 has been observed in several types of tumor cells. In this study, we demonstrate constitutively activated Stat3 in several human lung cancer cell lines and in tumor cells infiltrated in the pleurae of patients with adenocarcinoma cell lung cancer (ADCLC) and MPE. The observations suggest that activated Stat3 plays a role in the pathogenesis of ADCLC. In PC14PE6/AS2 cells, a Stat3-positive human ADCLC cell line, autocrine IL-6 activated Stat3 via JAKs, not via Src kinase. PC14PE6/AS2 cells express higher VEGF mRNA and protein than do Stat3-negative PC14PE6/AS2/dnStat3 cells. In an animal model, PC14P6/AS2/dnStat3 cells produced no MPE and less lung metastasis than did PC14P6/AS2 cells. PC14PE6/AS2 cells also expressed higher VEGF protein, microvessel density, and vascular permeability in tumors than did PC14P6/AS2/dnStat3 cells. Therefore, we hypothesize that autocrine IL-6 activation of Stat3 in ADCLC may be involved in the formation of malignant pleural effusion by upregulating VEGF. Higher levels of IL-6 and VEGF were also found in the pleural fluids of patients with ADCLC than in patients with congestive heart failure. The autocrine IL-6/Stat3/VEGF signaling pathway may also be activated in patients with ADCLC and MPE. These findings provide novel targets for the management of MPE.

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1209464

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
Niu, G., Wright, K. L., Huang, M., Song, L., Haura, E., Turkson, J., Zhang, S., Wang, T., Sinibaldi, D., Coppola, D., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205260 · Cited by 1,207
Target gene specificity of E2F and pocket protein family members in living cells
Wells, J., Boyd, K. E., Fry, C. J., Bartley, S. M., & Farnham, P. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5797-5807.2000 · Cited by 229

Show all 0 references

Research works printed but not linked: 22

Anderson CB, Philpott GW, Ferguson TB . (1974). Cancer 33: 916–922. · DOI
Bihl M, Tamm M, Nauck M, Wieland H, Perruchoud AP, Roth M . (1998). Am J Resp Cell Mol Biol 19: 606–612. · DOI
Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C et al. (1999). Cell 98: 295–303. · DOI · Paper page
Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M et al. (1996). Nature 380: 435–439. · DOI
Fernandes A, Hamburger AW, Gerwin BI . (1999). Int J Cancer 83: 564–570. · DOI
Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS et al. (1996). Nature 380: 439–442. · DOI
Hoffman PC, Mauer AM, Vokes EE . (2000). Lancet 355: 479–485. · DOI
Hoheisel G, Izbicki G, Roth M, Chan CH, Reichenberger F, Schauer J et al. (1998). Respiration 65: 183–186. · DOI
Hutchins D, Steel CM . (1994). Int J Cancer 58: 80–84. · DOI
Kishimoto T, Akira S, Taga T . (1992). Science 258: 593–597. · DOI · Paper page
Memon A, Zawadzki ZA . (1981). Curr Probl Cancer 5: 1–30. · DOI
Mesiano S, Ferrara N, Jaffe RB . (1998). Am J Pathol 153: 1249–1256. · DOI
Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba M, Kiuchi N et al. (1996). EMBO J 15: 3651–3658. · DOI · Paper page
Okamoto M, Lee C, Oyasu R . (1997). Cancer Res 57: 141–146. · DOI
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF . (1983). Science 219: 983–985. · DOI
Siegsmund MJ, Yamazaki H, Pastan I . (1994). J Urol 151: 1396–1399. · DOI
Song L, Turkson J, Karras JG, Jove R, Haura EB . (2003). Oncogene 22: 4150–4165. · DOI
Turkson J . (2004). Expert Opin Ther Targets 8: 409–422. · DOI
Wei LH, Kuo ML, Chen CA, Chou CH, Lai KB, Lee CN et al. (2003). Oncogene 22: 1517–1527. · DOI · Paper page
Yano S, Shinohara H, Herbst RS, Kuniyasu H, Bucana CD, Ellis LM et al. (2000b). Am J Pathol 157: 1893–1903. · DOI
Yokoyama A, Maruyama M, Ito M, Kohno N, Hiwada K, Yano S . (1992). Chest 102: 1055–1059. · DOI
Yu H, Jove R . (2004). Nat Rev Cancer 4: 97–105. · DOI · Paper page

Sorted by citations

IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“The IL-6–STAT3 pathway is involved in the epithelial–mesenchymal transition (EMT) (131, 132), tumor migration (133), cancer stemness (130, 134, 135) and the induction of hypoxia-inducible factor-1 α (HIF-1 α ) and vascular endothelial growth factor (VEGF), two key players for angiogenesis (136–140).”
Background
The Journal of Clinical Investigation
Witkin, E. M. (2016) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(94)92394-9 · Cited by 920
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
Sansone, P., Storci, G., Tavolari, S., Guarnieri, T., Giovannini, C., Taffurelli, M., Ceccarelli, C., Santini, D., Paterini, P., Marcu, K. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32533 · Cited by 779
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
Taniguchi, K., & Karin, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.001 · Cited by 724
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
Gao, S. P., Mark, K. G., Leslie, K., Pao, W., Motoi, N., Gerald, W. L., Travis, W. D., Bornmann, W., Veach, D., Clarkson, B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31871 · Cited by 666
“org Volume 117 Number 12 December 2007 3847 and inflammatory responses, but recent reports suggest that IL-6 expression is implicated in the regulation of tumor growth and metastatic spread, including lung cancers (21, 22).”
Background
The role of IL-6/JAK2/STAT3 signaling pathway in cancers
Huang, B., Lang, X., & Li, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1023177 · Cited by 538
“IL-6 increases in serum and malignant pleural effusion of patients with lung adenocarcinoma (49, 142).”
Background
Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?
Grivennikov, S. I., & Karin, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.020 · Cited by 373
“These two studies significantly expand our understanding of IL-6 involvement in epithelial cancers and stress the importance of autocrine/paracrine IL-6 signaling along with the work of others (Sasser et al., 2007; Yeh et al., 2006).”
Background
Vascular Endothelial Growth Factor and Its Relationship to Inflammatory Mediators
Angelo, L. S., & Kurzrock, R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2416 · Cited by 279
Malignant pleural effusion: from bench to bedside
Psallidas, I., Kalomenidis, I., Porcel, J., Robinson, B., & Stathopoulos, G. (2016) · European Respiratory Review · doi:10.1183/16000617.0019-2016 · Cited by 272
Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4
Todaro, M., Lombardo, Y., Francipane, M., Alea, M. P., Cammareri, P., Iovino, F., Stefano, A. D. D., Bernardo, C. D., Agrusa, A., Condorelli, G., et al. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402305 · Cited by 242
“Both infiltrating T cells in the tumor microenvironment and cancer cells can be the source of these molecules.(12,19,20) It has been shown that TH2 cytokines downregulate antitumor immunity leading to cancer progression and metastasis formation.”
Background
Lung adenocarcinoma distally rewires hepatic circadian homeostasis
Masri, S., Papagiannakopoulos, T., Kinouchi, K., Liu, Y., Cervantes, M., Baldi, P., Jacks, T., & Sassone-Corsi, P. (2016) · Cell · doi:10.1016/j.cell.2016.04.039 · Cited by 234
“plays an important role in progression of lung adenocarcinoma (Gao et al., 2007; Yeh et al., 2006).”
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher, D., Chen, Q., Skitzki, J. J., Muhitch, J., Zhou, L., Appenheimer, M. M., Vardam, T. D., Weis, E. L., Passanese, J., Wang, W.-C., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44952 · Cited by 225
Malignant pleural effusion: tumor-host interactions unleashed
Stathopoulos, G., & Kalomenidis, I. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0465pp · Cited by 194
Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
Lai, S. Y., & Johnson, F. M. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.04.001 · Cited by 193
“In addition, IL-6 production and STAT3 activation are associated with the development of malignant pleural effusion (Yeh et al., 2006).”
Background
JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling
Song, L., Rawal, B., Nemeth, J. A., & Haura, E. B. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0502 · Cited by 184
“Our previous study found IL-6 to be a strong activator of STAT3 in lung cancer cells and along with its expression in lung cancer tumors suggests that this pathway could be responsible for constitutive STAT3 levels in tumor cells harboring activated EGFR (7, 14, 15).”
Background
IL‐6 enriched lung cancer stem‐like cell population by inhibition of cell cycle regulators via DNMT1 upregulation
Liu, C., Lin, J., Hsu, T., Su, K., Li, A. F., Hsu, H., & Hung, S. (2015) · International Journal of Cancer · doi:10.1002/ijc.29033 · Cited by 169
“The expression of certain cytokines or chemokines in the tumor microenvironment is reported to be associated with tumor progression and patient survival.(21,22) We have reported that in lung cancer, IL-6 secreted by mesenchymal stem cells enhanced tumor initiation through the IL-6/ JAK2/STAT3 pathway.”
Background
Activation of the Signal Transducers and Activators of the Transcription 3 Pathway in Alveolar Epithelial Cells Induces Inflammation and Adenocarcinomas in Mouse Lung
Li, Y., Du, H., Qin, Y., Roberts, J., Cummings, O. W., & Yan, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0647 · Cited by 142
EGFR-Mutated Non-Small Cell Lung Cancer and Resistance to Immunotherapy: Role of the Tumor Microenvironment
Madeddu, C., Donisi, C., Liscia, N., Lai, E., Scartozzi, M., & Macciò, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126489 · Cited by 161
“Tobacco smoking is known to induce KRAS mutations and thereby stimulate IL-6 expression in the lung epithelium [44], promoting lung cancer cell proliferation and migration through the STAT3 pathway activation [45].”
Background
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells
Borriello, L., Nakata, R., Sheard, M. A., Fernández, G. E., Sposto, R., Malvar, J., Blavier, L., Shimada, H., Asgharzadeh, S., Seeger, R. C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2586 · Cited by 184
“Activation of STAT3 by IL6 has already been reported in neuroblastoma and other cancer tumors (23, 38, 39), but by demonstrating that blocking IL6 or its receptor is not sufficient to block STAT3 activation, the data indicate that other soluble factors than IL6 present in the CM activate STAT3 and ERK1/2.”
Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis
Lastrucci, C., Bénard, A., Balboa, L., Pingris, K., Souriant, S., Poincloux, R., Saati, T. A., Rasolofo, V., González-Montaner, P., Inwentarz, S., et al. (2015) · Cell Research · doi:10.1038/cr.2015.123 · Cited by 139
Antiapoptotic Activity of Autocrine Interleukin-22 and Therapeutic Effects of Interleukin-22-Small Interfering RNA on Human Lung Cancer Xenografts
Zhang, W.-C., Chen, Y.-Y., Wei, H.-M., Zheng, C.-G., Sun, R., Zhang, J., & Tian, Z. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4401 · Cited by 127
Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors
Lee, M., Hirpara, J. L., Eu, J. Q., Sethi, G., Wang, L., Goh, B.-C., & Wong, A. L. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101073 · Cited by 129
Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation
Bharadwaj, U., Marin-Muller, C., Li, M., Chen, C., & Yao, Q. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr075 · Cited by 118
The role of the interleukin (IL)-6/IL-6 receptor axis in cancer
Taher, M. Y., Davies, D. M., & Maher, J. F. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180136 · Cited by 138
Curcumin
Alexandrow, M. G., Song, L., Altiok, S., Gray, J., Haura, E. B., & Kumar, N. B. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e32834ef194 · Cited by 125
“Our previous study found IL-6 to be a strong activator of Stat3 in lung cancer cells and along with its expression in lung cancer tumors suggests that this pathway could be responsible for constitutive Stat3 levels in lung cancer tumor cells (Song et al., 2003; Haura et al., 2006; Yeh et al., 2006).”
Background
Metformin Inhibits the IL-6-Induced Epithelial-Mesenchymal Transition and Lung Adenocarcinoma Growth and Metastasis
Zhao, Z., Cheng, X., Wang, Y., Han, R., Li, L., Xiang, T., He, L., Long, H., Zhu, B., & He, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095884 · Cited by 113
“Interleukin-6 (IL-6) is another key factor in the tumor microenvironment, which is involved in tumorigenesis and progression [18,19].”
Background
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer‐derived CD133‐positive cells
Hsu, H., Huang, P., Chang, Y., Tzao, C., Chen, Y., Shih, H., Hung, S., Chen, Y., Tseng, L., & Chiou, S. (2011) · Cancer · doi:10.1002/cncr.25869 · Cited by 113
“Constitutively activated STAT3 reportedly was detected in several human lung cancer cell lines and in tumor cells that infiltrated the pleurae of patients who had malignant pleural effusionassociated lung adenocarcinoma.(32) Several reports have indicated the synergistic effect of cucurbitacin with known chemotherapeu…”
Background
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis
Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W. G., Rose‐John, S., Ruwanpura, S. M., & Jenkins, B. J. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2388 · Cited by 122
Mast cells mediate malignant pleural effusion formation
Giannou, A. D., Marazioti, A., Σπέλλα, Μ., Kanellakis, N. I., Apostolopoulou, H., Psallidas, I., Prijovich, Z. M., Vreka, M., Zazara, D. E., Lilis, I., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79840 · Cited by 108
“Interestingly, none of the 12 genes examined was inducible by BMMCCM in MPE-defective B16F10 cells; however, both NF-κB– target gene Ccl2 and STAT3-target gene Myc were strongly upregulated by BMMC-CM selectively in MPE-competent adenocarcinoma cells (Figure 12A).”
Result
A Central Role for Tumor-derived Monocyte Chemoattractant Protein-1 in Malignant Pleural Effusion
Stathopoulos, G. T., Psallidas, I., Moustaki, A., Moschos, C., Kollintza, A., Karabela, S. P., Porfyridis, I., Vassiliou, S., Karatza, M., Zhou, Z., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn325 · Cited by 100
Metformin Enhances Cisplatin Cytotoxicity by Suppressing Signal Transducer and Activator of Transcription–3 Activity Independently of the Liver Kinase B1–AMP-Activated Protein Kinase Pathway
Lin, C., Yeh, H.-H., Huang, W.-L., Yan, J.-J., Lai, W., Su, W., Chen, H. H. W., & Su, W. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0244oc · Cited by 104
Self-citation
Malignant pleural effusion: current understanding and therapeutic approach
Gonnelli, F., Hassan, W., Bonifazi, M., Pinelli, V., Bedawi, E. O., Porcel, J. M., Rahman, N. M., & Mei, F. (2024) · Respiratory Research · doi:10.1186/s12931-024-02684-7 · Cited by 107
Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype.
Sorrentino, C., & Carlo, E. D. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0400oc · Cited by 100
Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer
Qu, Z., Sun, F., Zhou, J., Li, L., Shapiro, S. D., & Xiao, G. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3042 · Cited by 108
“Mechanistic studies suggest that IL6 promotes lung cancer cell proliferation and migration through activation of the transcription factor STAT3 (4, 7, 14).”
Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells
Chiu, W. C., Luo, S.-J., Chen, C., Cheng, J., Hsieh, C.-Y., Wang, C., Huang, W., Su, W., & Lin, C. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.016 · Cited by 103
“Fidler) (MD Anderson Cancer Center, Houston, TX) in nude mice [17].”
BackgroundSelf-citation
Activation of the IL-6R/Jak/Stat Pathway is Associated with a Poor Outcome in Resected Pancreatic Ductal Adenocarcinoma
Denley, S. M., Jamieson, N. B., McCall, P., Oien, K. A., Morton, J. P., Carter, C. R., Edwards, J., & McKay, C. J. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2168-7 · Cited by 105
Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease
Richens, J. L., Urbanowicz, R. A., Lunt, E. A. M., Metcalf, R., Corne, J. M., Fairclough, L. C., & O’Shea, P. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-29 · Cited by 26
Mesothelin-Induced Pancreatic Cancer Cell Proliferation Involves Alteration of Cyclin E via Activation of Signal Transducer and Activator of Transcription Protein 3
Bharadwaj, U., Li, M., Chen, C., & Yao, Q. C. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0095 · Cited by 109
“kin-6/gp130/JAK2/Stat3 pathway (42, 43), the autocrine ErbB2/ Stat3 pathway (27), the transforming growth factor-a/epidermal growth factor receptor/Stat3 pathway (20), and the mutant epidermal growth factor receptor/Stat3 pathway (44).”
Background
STAT3 can be activated through paracrine signaling in breast epithelial cells
Lieblein, J., Ball, S. L., Hutzen, B. J., Sasser, A. K., Lin, H.-J. L., Huang, T. H. ‐., Hall, B. M., & Lin, J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-302 · Cited by 96
Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease
Qu, P., Roberts, J., Yuan, L., Albrecht, M. E., Cummings, O. W., Eble, J. N., Du, H., & Yan, C. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.05.025 · Cited by 98
Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway
Hsu, H., Lin, J.-H., Hsu, T.-W., Su, K., Wang, C.-W., Yang, K., Chiou, S., & Hung, S. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.07.001 · Cited by 93
A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect
Kan, P., Tsao, C.-W., Wang, A.-J., Su, W.-C., & Liang, H.-F. (2010) · Journal of Drug Delivery · doi:10.1155/2011/629234 · Cited by 90
“The PC14PE6/AS2 cells express higher VEGF proteins, microvessel density, and vascular permeability in tumors [24].”
BackgroundSelf-citation
Antibody-free isolation of rare cancer cells from blood based on 3D lateral dielectrophoresis.
Cheng, I., Huang, W.-L., Chen, T.-Y., Liu, C.-W., Lin, Y.-D., & Su, W.-C. (2015) · Lab on a Chip · doi:10.1039/c5lc00120j · Cited by 89
Self-citation
Tumor Necrosis Factor-α Promotes Malignant Pleural Effusion
Stathopoulos, G. T., Kollintza, A., Moschos, C., Psallidas, I., Sherrill, T. P., Pitsinos, E. N., Vassiliou, S., Karatza, M., Papiris, S. A., Graf, D., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1064 · Cited by 117
“a skin vascular permeability (Miles) assay (7, 27, 36, 37).”
Background
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells
Tomida, M., Ohtake, H., Yokota, T., Kobayashi, Y., & Kurosumi, M. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0318-6 · Cited by 86
“…Cancer Center, 818 Komuro, Ina, Saitama 362-0806, Japan breast cancer (Watson and Miller 1995), lung cancer (Fernandes et al. 1999; Song et al. 2003; Yeh et al. 2006), pancreatic cancer (DeArmond et al. 2003; Wei et al. 2003), gastric cancer (Kanda et al. 2004), and colon cancer (Ma et al.…”
Background
Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells
Huang, W.-L., Yeh, H.-H., Lin, C.-C., Lai, W.-W., Chang, J.-Y., Chang, W.-T., & Su, W.-C. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-309 · Cited by 86
“degrees of Stat3 activation and inactivation on the mRNA expression and the secretion of IL-6 using parental AS2 cells and various previously established AS2derived cell lines with different Stat3 activation status: vector control cells, two AS2/S3C cells, two AS2/S3D cells, and two AS2/S3F cells [2,10].”
BackgroundMethodInfluentialSelf-citation
Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer
Liu, C.-M., Yang, L., Xu, H.-Y., Zheng, S.-F., Wang, Z.-Y., Wang, S., Yang, Y.-N., Zhang, S.-Y., Feng, X., Sun, N., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02356-7 · Cited by 85
Serum levels of nicotinamide N-methyltransferase in patients with lung cancer
Tomida, M., Mikami, I., Takeuchi, S., Nishimura, H., & Akiyama, H. (2009) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-009-0563-y · Cited by 80
Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization
Klettner, A., Kauppinen, A., Błasiak, J., Roider, J., Salminen, A., & Kaarniranta, K. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.013 · Cited by 83
“In addition, the function of lysosomes is impaired by the ingestion of UV-light treated POS, which induces the secretion of VEGF and IL-6 in the RPE (Lueck et al., 2012), which may, in turn, induce VEGF via an autocrine pathway (Nakahara et al., 2003; Yeh et al., 2006).”
Background
17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells
Wang, Y., Ma, X., Yan, S., Shen, S., Zhu, H., Gu, Y. J., Wang, H., Qin, G., & Yu, Q. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0462 · Cited by 94
Cytokine Storms in Cancer and COVID-19
Turnquist, C., Ryan, B. M., Horikawa, I., Harris, B. T., & Harris, C. C. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.09.019 · Cited by 92
Iron and lung cancer
Kuang, Y., & Wang, Q. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.08.007 · Cited by 87
Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1α and VEGF expression in non-small cell lung cancer cells
Li, G., Li, H., Zhang, E., Shi, J., Zhang, Q., Le, A. D., Zhou, K., & Tang, X. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.07.012 · Cited by 80
STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells
Lin, H.-Y., Chiang, C.-H., & Hung, W. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.349 · Cited by 78
“In lung cancer, signal transducer and activator of transcription 3 (STAT3) activation is important for tumour development and promotion (Song et al, 2003; Yeh et al, 2006).”
Background
EPS8 Facilitates Cellular Growth and Motility of Colon Cancer Cells by Increasing the Expression and Activity of Focal Adhesion Kinase
Maa, M., Lee, J., Chen, Y.-J., Chen, Y., Lee, Y.-C., Wang, S., Huang, C.-C., Chow, N.-H., & Leu, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610280200 · Cited by 76
A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.
Yeh, C.-T., Huang, W.-C., Rao, Y., Ye, M., Lee, W.-H., Wang, L.-S., Tzeng, D. T. W., Wu, C.-H., Shieh, Y., Huang, C.-Y. F., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt255 · Cited by 77
“It has been established that IL-6 induced STAT3 activation and contributes to the lung carcinogenesis and metastasis (33).”
Background
The Role of Vascular Endothelial Growth Factor in the Pathogenesis, Diagnosis and Treatment of Malignant Pleural Effusion
Bradshaw, M., Mansfield, A. S., & Peikert, T. (2013) · Current Oncology Reports · doi:10.1007/s11912-013-0315-7 · Cited by 82
Cytokine Plasma Levels: Reliable Predictors for Radiation Pneumonitis?
Rübe, C., Palm, J., Erren, M., Fleckenstein, J., König, J., Remberger, K., & Rübe, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002898 · Cited by 77
“In NSCLC cell lines IL-6 has been shown to be involved in tumour cell proliferation, in tumour promotion and progression [50,51,52,53,54,55,56].”
The Key Role of IL-6–Arginase Cascade for Inducing Dendritic Cell–Dependent CD4+ T Cell Dysfunction in Tumor-Bearing Mice
Narita, Y., Kitamura, H., Wakita, D., Sumida, K., Masuko, K., Terada, S., Nakano, K., & Nishimura, T. (2013) · Journal of Immunology · doi:10.4049/jimmunol.1103797 · Cited by 75
Effects of PM2.5Collected from Cache Valley Utah on Genes Associated with the Inflammatory Response in Human Lung Cells
Watterson, T. L., Sorensen, J., Martin, R. S., & Coulombe, R. A. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701457746 · Cited by 81
Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities
Parakh, S., Ernst, M., & Poh, A. R. (2021) · Cancers · doi:10.3390/cancers13246228 · Cited by 77
“Inhibition of STAT3 in human PC14PE6/AS2 lung adenocarcinoma cells reduces tumor-associated VEGF expression, angiogenesis, and vascular permeability [49], while pharmacologic inhibition or siRNA-mediated interference of JAK2/STAT3 signaling in A549 NSCLC cells impairs angiogenesis by decreasing VEGF expression [45,50].”
Background
Bacteria Peptidoglycan Promoted Breast Cancer Cell Invasiveness and Adhesiveness by Targeting Toll-Like Receptor 2 in the Cancer Cells
Xie, W., Huang, Y., Xie, W., Guo, A., & Wu, W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010850 · Cited by 67
“For examples, IL-6 promotes cancer cell proliferation and recent studies showed that IL-6 also contributed to cancer cell malignant properties and effusion respectively in lung and breast cancer[43,44]; TGF-b induces cancer cell invasion and EMT in breast cancer[27,45]; VEGF and MMP9 are also regarded as indispensable…”
Background
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Wang, L., Astone, M., Alam, S. K., Zhu, Z., Pei, W., Frank, D., Burgess, S., & Hoeppner, L. H. (2020) · bioRxiv · doi:10.1101/2020.10.27.358374 · Cited by 67
“Prior studies suggest other permeability inducers, such as IL-6, IgG, IgE, histamine, lipopolysaccharides, and eotaxin, mediate vascular permeability through STAT3 signaling 25,55-61 .”
STAT3 and metabolism: How many ways to use a single molecule?
Demaria, M., Camporeale, A., & Poli, V. (2014) · International Journal of Cancer · doi:10.1002/ijc.28767 · Cited by 69
“However, S-P can be detected on STAT3 in the absence of Y-P, and its levels correlate with the Gleason score in prostate cancer and with an estrogen receptor (ER) negative status and high tumor stage in breast cancer.(30,31) Although most of these reports correlate S-P with transcriptional activity, a novel, non-trans…”
Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.
Stathopoulos, G., Sherrill, T., Karabela, S. P., Goleniewska, K., Kalomenidis, I., Roussos, C., Fingleton, B., Yull, F., Peebles, R., & Blackwell, T. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0001oc · Cited by 67
Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer
Sharma, J., & Larkin, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00324 · Cited by 77
“However, under pathological conditions activated STAT3 has been implicated in hematological and non-hematological tumors, largely through promotion of autocrine IL-6 signaling and secretion that drives cancer progression and multidrug resistance (Koudstaal et al., 1967; Buettner et al., 2002; Yu and Jove, 2004; Yeh et…”
Background
Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor
Becker, T. M., Boyd, S., Mijatov, B., Gowrishankar, K., Snoyman, S., Pupo, G. M., Scolyer, R. A., Mann, G. J., Kefford, R. F., Zhang, X. D., et al. (2013) · Oncogene · doi:10.1038/onc.2013.45 · Cited by 72
Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer
Lewis, K. M., Bharadwaj, U., Eckols, T. K., Kolosov, M., Kasembeli, M. M., Fridley, C., Siller, R., & Tweardy, D. J. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.09.014 · Cited by 63
The intersection of COVID-19 and cancer: signaling pathways and treatment implications
Zong, Z., Wei, Y., Ren, J., Zhang, L., & Zhou, F. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01363-1 · Cited by 74
“For example, exposure to carcinogens, such as cigarette smoking, has been shown to induce mutations in KRAS, which in turn boost IL-6 expression levels in the lung epithelium, facilitating lung adenocarcinoma pathogenesis through the JAK/STAT3 pathway [61, 62].”
Background
Upregulation of Tissue Factor by Activated Stat3 Contributes to Malignant Pleural Effusion Generation via Enhancing Tumor Metastasis and Vascular Permeability in Lung Adenocarcinoma
Yeh, H.-H., Chang, W.-T., Lu, K.-C., Lai, W., Liu, H.-S., & Su, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075287 · Cited by 58
Self-citation
Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non–Small Cell Lung Cancer
Wu, D., Tsai, L., Chen, P.-M., Lee, M.-C., Wang, L., Chen, C., Cheng, Y., & Lee, H. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.07.032 · Cited by 56
“This is especially the case for adenocarcinoma with epidermal growth factor receptor mutation, which suggests that IL-6 is a key player in lung adenocarcinoma tumorigenesis.(54,55) A recent report using IKK and IL-6 knockout mice demonstrated that IKK /NF- B activation controls the development of liver metastasis by w…”
Background
Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis
Ihara, S., Kida, H., Arase, H., Tripathi, L. P., Chen, Y., Kimura, T., Yoshida, M., Kashiwa, Y., Hirata, H., Fukamizu, R., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4062 · Cited by 56
Vascular Changes and Hypoxia in Periodontal Disease as a Link to Systemic Complications
Çelik, D. T., & Kantarcı, A. (2021) · Pathogens · doi:10.3390/pathogens10101280 · Cited by 71
Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway
Kuang, Y., Guo, W., Jing, L., Xu, D., Liao, Y., Zhao, H., Du, X., Wang, H., Xu, M., Song, H., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1528-y · Cited by 62
17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression
Huang, Q.-F., Zhang, Z., Liao, Y.-D., Liu, C., Fan, S., Wei, X., Ai, B., & Xiong, J. (2018) · Journal of experimental & clinical cancer research : CR · doi:10.1186/s13046-018-0804-5 · Cited by 55
Rapid isolation and detection of cancer cells by utilizing integrated microfluidic systems.
Lien, K., Chuang, Y.-H., Hung, L.-Y., Hsu, K.-F., Lai, W.-W., Ho, C., Chou, C.-Y., & Lee, G.-B. (2010) · Lab on a Chip · doi:10.1039/c005178k · Cited by 55
Self-citation
IL-6 family cytokines in respiratory health and disease
Dawson, R., Jenkins, B. J., & Saad, M. I. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155520 · Cited by 68
The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
Malanga, D., Marco, C. D., Guerriero, I., Colelli, F., Rinaldo, N., Scrima, M., Mirante, T., Vitis, C. D., Zoppoli, P., Ceccarelli, M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5626 · Cited by 49
“In fact, although the most prominent role of IL-6 is to regulate immune and inflammatory responses [47], IL-6 has also been implicated in the regulation of growth, drug resistance and metastatic spread of tumors [48, 49].”
Local Ischemia and Increased Expression of Vascular Endothelial Growth Factor Following Ocular Dissemination of Mycobacterium tuberculosis
Thayil, S., Albini, T., Nazari, H., Moshfeghi, A., Parel, J., Rao, N., & Karakousis, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028383 · Cited by 50
“VEGF is upregulated by inflammatory cytokines such as IL-6 [9], tumor necrosis factor-a (TNF-a) [10], and IL-8 [11], and may play a major role in inflammatory diseases such as rheumatoid arthritis [12], asthma [13], Churg-Strauss syndrome [14] and Behcet’s disease [15].”
Background
Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways
Esparza‐López, J., Alvarado-Muñoz, J. F., Escobar-Arriaga, E., Ulloa‐Aguirre, A., & Ibarra-Sánchez, M. D. J. (2019) · BMC Cancer · doi:10.1186/s12885-019-5945-1 · Cited by 63
Regulation of tumor angiogenesis by the local environment
Hall, K. L. (2009) · Frontiers in bioscience · doi:10.2741/3615 · Cited by 50
Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells
Su, W.-P., Lo, Y.-C., Yan, J., Liao, I., Tsai, P.-J., Wang, H., Yeh, H.-H., Lin, C., Chen, H. H. W., Lai, W., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs253 · Cited by 45
“We established the human lung adenocarcinoma PC14PE6/AS2 (AS2) cell line, which has increased metastatic susceptibility and constitutively activated endogenous Stat3, in our laboratory (23).”
BackgroundMethodSelf-citation
Tocilizumab inhibits neuronal cell apoptosis and activates STAT3 in cerebral infarction rat model
Wang, S.-J., Zhou, J., Kang, W.-J., Dong, Z., & Wang, H. (2016) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2016.853 · Cited by 46
“Another important regulatory relationship regarding STAT3 is that IL-6 plays vital roles in activating STAT3, which is crucial for the blocked apoptosis during inflammatory processes, as well as the pathogenesis of diseases [24], such as lung adenocarcinoma and malignant pleural effusion [25].”
Zoledronic Acid Is Effective against Experimental Malignant Pleural Effusion
Stathopoulos, G. T., Moschos, C., Loutrari, H. V., Kollintza, A., Psallidas, I., Karabela, S. P., Magkouta, S., Zhou, Z., Papiris, S. A., Roussos, C., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200710-1513oc · Cited by 49
Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer
Ervin, E.-H., French, R., Chang, C., & Pauklin, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.11.001 · Cited by 53
Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression
Takada, K., Okamoto, T., Tominaga, M., Teraishi, K., Akamine, T., Takamori, S., Katsura, M., Toyokawa, G., Shoji, F., Okamoto, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181598 · Cited by 48
Glycosylation regulates the function and membrane localization of KCC4
Weng, T.-Y., Chiu, W., Liu, H., Cheng, H.-C., Shen, M., Mount, D. B., & Chou, C.-Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.01.018 · Cited by 49
Self-citation
Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation
Schütz, A., Röser, K., Klitzsch, J., Lieder, F., Aberger, F., Gruber, W., Mueller, K. M., Pupyshev, A. B., Moriggl, R., & Friedrich, K. (2015) · Translational Oncology · doi:10.1016/j.tranon.2015.02.002 · Cited by 45
“For instance, IL-6 and its receptor were implicated in the progression of non–small cell lung carcinoma (NSCLC) [12] and were shown to induce enhanced STAT3 activity [13,14].”
Background
IL-12 Can Target Human Lung Adenocarcinoma Cells and Normal Bronchial Epithelial Cells Surrounding Tumor Lesions
Airoldi, I., Carlo, E. D., Cocco, C., Caci, E., Cilli, M., Sorrentino, C., Sozzi, G., Ferrini, S., Rosini, S., Bertolini, G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006119 · Cited by 42
“IL-6 promotes lung cancer growth and metastasis [11,13] and we [10] have demonstrated that IL-12 dampens IL-6 production in mouse splenocytes.”
Background
Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor
Aryappalli, P., Shabbiri, K., Masad, R. J., Al-Marri, R. H., Haneefa, S. M., Mohamed, Y. A., Arafat, K., Attoub, S., Cabral-Marques, O., Ramadi, K. B., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184340 · Cited by 45
Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion
Chen, Y.-F., Chou, C.-Y., Wilkins, R., Ellory, J., Mount, D., & Shen, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2284 · Cited by 40
Proteomic-Based Approaches for the Study of Cytokines in Lung Cancer
Marrugal, Á., Ojeda, L., Paz-Ares, L. G., Molina‐Pinelo, S., & Ferrer, I. (2016) · Disease Markers · doi:10.1155/2016/2138627 · Cited by 38
“It has been shown that IL-6 displays carcinogenic effects through the activation of the STAT3 pathway [84, 85, 93, 94].”
Background
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
Hung, C.-H., Wu, S., Yao, C.-I., Yeh, H.-H., Lin, C., Chu, C., Huang, T.-Y., Shen, M., Lin, C., & Su, W. (2024) · Nature Communications · doi:10.1038/s41467-024-51831-7 · Cited by 35
“Large quantities of IL6 in malignant pleural effusions (MPEs) have been reported in lung cancer patients 39 ; thus, we isolated lung adenocarcinoma cells from the MPEs (termed “ MPECs ” ) of 15 NSCLC patients to study the glycosylation pattern of lung cancer cell-derived IL6.”
Self-citation
DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells
Im, J., Kim, B., Lee, K., Chun, S.-Y., Kang, M., & Won, M. (2020) · Oncogenesis · doi:10.1038/s41389-019-0187-2 · Cited by 48
Malignant pleural fluid from mesothelioma has potent biological activities
Hui, M.-C.-A., Lansley, S., della Vergiliana, J. V. D., Tan, A.-L., Thomas, R., Leong, S., Creaney, J., & Lee, Y. C. G. (2017) · Respirology (Carlton South. Print) · doi:10.1111/resp.12874 · Cited by 38
Gender Dependence for a Subset of the Low-Abundance Signaling Proteome in Human Platelets
Eidelman, O., Jozwik, C., Huang, W., Srivastava, M., Rothwell, S., Jacobowitz, D., Ji, X., Zhang, X., Guggino, W., Wright, J. M., et al. (2010) · Human Genomics and Proteomics · doi:10.4061/2010/164906 · Cited by 37
Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells
Komiya, K., Sueoka‐Aragane, N., Sato, A., Hisatomi, T., Sakuragi, T., Mitsuoka, M., Sato, T., Hayashi, S., Izumi, H., Tsuneoka, M., et al. (2009) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-009-0679-0 · Cited by 38
Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis.
Wang, C.-Y., Lin, Y.-S., Su, W., Chen, C.-L., & Lin, C.-O.-F. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-02-0174 · Cited by 36
“To develop a tumor model as described previously (Yeh et al., 2006), A549 cells in suspension (1 106 cells/0.”
MethodInfluentialSelf-citation
2-Hydroxy-3-methylanthraquinone inhibits lung carcinoma cells through modulation of IL-6-induced JAK2/STAT3 pathway
Sun, C., Yang, J., Cheng, H.-B., Shen, W., Jiang, Z.-Q., Wu, M.-J., Li, L., Li, W.-T., Chen, T.-T., Rao, X., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152848 · Cited by 35
Preclinical Evidence for Combined Use of Aromatase Inhibitors and NSAIDs as Preventive Agents of Tobacco-Induced Lung Cancer
Stabile, L. P., Farooqui, M., Kanterewicz, B. I., Abberbock, S. R., Kurland, B. F., Diergaarde, B. B., & Siegfried, J. M. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2017.11.126 · Cited by 42

Authors: Yeh, H.-H., Lai, W.-W., Chen, H. H. W., Liu, H.-S., & Su, W.-C.
Affiliations: National Cheng Kung University (TW)
National Cheng Kung University Hospital (TW)
Corresponding author: Liu, H-S
Su, W-C
ORCID: Su, W-C
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2006-03-06
Volume: 25
Issue: 31
Pages: 4300-4309
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1209464
OpenAlex: W2022200777
Cited by: 230
References: 0
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 11 · 2019: 15 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 16 · 2014: 6 · 2013: 16 · 2012: 17
FWCI: 6.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pleural and Pulmonary Diseases
Keywords: malignant pleural effusion, lung adenocarcinoma, interleukin-6, STAT3 activation, autocrine signaling, vascular endothelial growth factor, JAK signaling, non-small cell lung cancer, lung metastasis, tumor angiogenesis, pleural fluid biomarkers, microvessel density, vascular permeability
MeSH terms: Adenocarcinoma, Animals, Female, Humans, Lung Neoplasms, Male, Mice, Inbred BALB C, Mice, Nude, Interleukin-6, Pleural Effusion, Malignant, Vascular Endothelial Growth Factor A, Cell Line, Tumor, STAT3 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks