Coping with stress: multiple ways to activate p53

Surfing the p53 network

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CDK inhibitors: positive and negative regulators of G1-phase progression

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Cell Death

Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate

Gutierrez-Prat, N., Cubillos‐Rojas, M., Cánovas, B., Kuzmanic, A., Gupta, J., Igea, A., Llonch, E., Gaestel, M., & Nebreda, Á. R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024562118 · Cited by 17

Tumour supressor secreted frizzled related protein 1 regulates p53‐mediated apoptosis

Gauger, K. J., & Schneider, S. S. (2013) · Cell Biology International · doi:10.1002/cbin.10176 · Cited by 17

Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 signal

Trachootham, D., Chen, G., Zhang, W., Lu, W., Zhang, H., Liu, J., & Huang, P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.011 · Cited by 18

Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53

Fiorini, A., Sultana, R., Barone, E., Cenini, G., Perluigi, M., Mancuso, C., Cai, J., Klein, J. B., St. Clair, D., & Butterfield, D. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049846 · Cited by 16

Recognizing the Binding Pattern and Dissociation Pathways of the p300 Taz2-p53 TAD2 Complex

Li, T., Motta, S., Stevens, A. O., Song, S., Hendrix, E., Pandini, A., & He, Y. J. (2022) · JACS Au · doi:10.1021/jacsau.2c00358 · Cited by 16

Effects of two workload-matched high intensity interval training protocols on regulatory factors associated with mitochondrial biogenesis in the soleus muscle of diabetic rats

Delfan, M., Vahed, A., Bishop, D. J., Juybari, R. A., Laher, I., Saeidi, A., Granacher, U., & Zouhal, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.927969 · Cited by 18

Genotoxin-producing Salmonella enterica induces tissue-specific types of DNA damage and DNA damage response outcomes

Chiloeches, M. L., Bergonzini, A., Martin, O. C. B., Bergstein, N., Erttmann, S. F., Aung, K. M., Gekara, N. O., Avila‐Cariño, J., Pateras, I. S., & Frisan, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1270449 · Cited by 15

Therapeutic potential of mushrooms: A review on NF-κB modulation in chronic inflammation

Amirullah, N. A., Abdullah, E., Abidin, N. Z., Abdullah, N., & Manickam, S. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105059 · Cited by 16

p53 and metabolism: Old player in a new game

Sen, N., Satija, Y. K., & Das, S. (2012) · Transcription · doi:10.4161/trns.20094 · Cited by 16

Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling

Sui, Y., Han, Y., Zhao, X., Li, D., & Li, G. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.135 · Cited by 16

Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson’s Disease Models

Bi, M., Jiao, Q., Du, X., & Jiang, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00021 · Cited by 16

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

Stefaniak, J., Lewis, A. M., Conole, D., Galan, S. R. G., Bataille, C. J. R., Wynne, G. M., Castaldi, M. P., Lundbäck, T., Russell, A. J., & Huber, K. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00665 · Cited by 16

Genome Damage Sensing Leads to Tissue Homeostasis in Drosophila

Khan, C., Muliyil, S., & Rao, B. J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2018.12.001 · Cited by 15

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Fang, D., Hu, H. Q., Zhao, K., Xu, A., Yu, C., Zhu, Y., Yu, N., Yao, B., Tang, S., Wu, X., et al. (2023) · Advanced Science · doi:10.1002/advs.202303336 · Cited by 14

Lentivirus-mediated knockdown of TSP50 suppresses the growth of non-small cell lung cancer cells via G0/G1 phase arrest

Qiao, W., Hu, H., Shi, B., Zang, L., JIN, W., & LIN, Q. (2016) · Oncology Reports · doi:10.3892/or.2016.4763 · Cited by 15

Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma

Lora, V., Grings, A. O., Capp, E., Corleta, H. V. E., & Brum, I. S. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2245-2 · Cited by 15

Glucosidase II exhibits similarity to the p53 tumor suppressor in regards to structure and behavior in response to stress signals: A potential novel cancer biomarker

Suradej, B., Pata, S., Kasinrerk, W., & Cressey, R. (2013) · Oncology Reports · doi:10.3892/or.2013.2721 · Cited by 16

Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells

Liu, Z., Zhang, C., Skamagki, M., Khodadadi‐Jamayran, A., Zhang, W., Kong, D., Chang, C.-W., Feng, J., Han, X., Townes, T. M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.006 · Cited by 15

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1)

Kim, H., Lee, S. H., Lee, M.-N., Oh, G. T., Choi, K., & Choi, E. Y. (2013) · Oncotarget · doi:10.18632/oncotarget.1318 · Cited by 15

Circ_0004015 silencing represses cisplatin chemoresistance and tumor progression by reducing KLF8 in a miR-198-dependent manner in non-small cell lung cancer

Li, Y., Yang, X., & Xiong, X. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110294 · Cited by 14

Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis

Wang, C., Yang, Y., Wu, X., Li, J., Liu, K., Fang, D., Li, B., Shan, G., Mei, X., Wang, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111409119 · Cited by 14

Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis

Demidov, O. N., Zhu, Y., Kek, C., Goloudina, A. R., Motoyama, N., & Bulavin, D. V. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.57 · Cited by 14

Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

Abramowitz, J., Neuman, T., Perlman, R., & Ben‐Yehuda, D. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0249-2 · Cited by 14

Mechanisms of the embryo's response to embryopathic stressors: a focus on p53

Torchinsky, A. M., & Toder, V. (2010) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2010.01.003 · Cited by 14

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

Hjerpe, R., Aillet, F., Lopitz‐Otsoa, F., Lang, V., Torres-Ramos, M., Farrás, R., Hay, R. T., & Rodríguez, M. S. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.010 · Cited by 14

Disruption of NADPH homeostasis by total flavonoids from Adinandra nitida Merr. ex Li leaves triggers ROS-dependent p53 activation leading to apoptosis in non-small cell lung cancer cells

Lan, T., He, S., Luo, X., Pi, Z., Lai, W., Jiang, C., Gan, J., Wei, S., Wu, Z., Yun, C., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118340 · Cited by 13

MKK7 and ARF

Kotsinas, A., Papanagnou, P., Galanos, P., Schramek, D., Townsend, P. A., Penninger, J. M., Bártek, J., & Gorgoulis, V. G. (2014) · Cell Cycle · doi:10.4161/cc.28654 · Cited by 13

Multiple parameters are involved in the effects of cadmium on prenatal hepatocytes

Bruscalupi, G., Massimi, M., Devirgiliis, L. C., & Leoni, S. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.07.018 · Cited by 13

Lipid Metabolic-Related Signature CYP19A1 is a Potential Biomarker for Prognosis and Immune Cell Infiltration in Gastric Cancer

Wang, N., Huang, X., & Qian, L. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s378212 · Cited by 12

Sterigmatocystin induces G1 arrest in primary human esophageal epithelial cells but induces G2 arrest in immortalized cells: key mechanistic differences in these two models

Wang, J., Huang, S., Xing, L., Cui, J., Tian, Z., Shen, H., Jiang, X., Xia, Y., Wang, J., & Zhang, X. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1362-z · Cited by 12

Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis

Oster, M., Galhuber, M., Krstić, J., Steinhoff, J. S., Lenihan-Geels, G. N., Wulff, S., Kiefer, M. F., Petricek, K. M., Wowro, S. J., Flores, R. E., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102287 · Cited by 12

p53 and p21(Waf1) Are Recruited to Distinct PML‐Containing Nuclear Foci in Irradiated and Nutlin‐3a‐Treated U2OS Cells

Shen, H., & Maki, C. G. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22852 · Cited by 12

Short-Term Effects of Low-LET Radiation on the Endothelial Barrier: Uncoupling of PECAM-1 and the Production of Endothelial Microparticles

Templin, T., Sharma, P. M., Guida, P. M., & Grabham, P. W. (2016) · Radiation Research · doi:10.1667/rr14510.1 · Cited by 12

Protein music of enhanced musicality by music style guided exploration of diverse amino acid properties

Tay, N. W., Liu, F., Wang, C., Zhang, H., Zhang, P., & Chen, Y. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07933 · Cited by 11

The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death

Gupta, S., Silveira, D. A., Mombach, J. C. M., & Hashimoto, R. F. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.08.003 · Cited by 11

Polyphenolic Compounds Targeting p53-Family Tumor Suppressors: Current Progress and Challenges

Étienne-Selloum, N., Dandache, I., Sharif, T., Auger, C., & Valerie, B. (2013) · InTech eBooks · doi:10.5772/56102 · Cited by 13

The Role of Chromosome Missegregation in Cancer Development: A Theoretical Approach Using Agent-Based Modelling

Araujo, A., Baum, B., & Bentley, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072206 · Cited by 11

A new transgenic mouse line to image chemically induced p53 activation in vivo

Briat, A., & Vassaux, G. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00742.x · Cited by 11

A Cell-Permeable Fusion Protein Based on Clostridium botulinum C2 Toxin for Delivery of p53 Tumorsuppressor into Cancer Cells

Fahrer, J., Rausch, J., & Barth, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072455 · Cited by 11

Cardiac transcription factor Nkx2.5 interacts with p53 and modulates its activity

Kojić, S., Nestorovic, A., Rakicevic, L. B., Protic, O., Jasnic-Savovic, J., Faulkner, G., & Radojkovic, D. P. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.02.001 · Cited by 11

Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks

Schaber, J., Lapytsko, A., & Flockerzi, D. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0971 · Cited by 11

How p53 wields the scales of fate

Goh, A. M., & Lane, D. P. (2012) · Transcription · doi:10.4161/trns.21297 · Cited by 11

Oxidative Stress and Drug Resistance in Cancer

Trachootham, D., Zhang, W., & Huang, P. (2009) · Springer eBooks · doi:10.1007/978-0-387-89445-4_7 · Cited by 12

Modulation of Cyclins, p53 and Mitogen-Activated Protein Kinases Signaling in Breast Cancer Cell Lines by 4-(3,4,5-Trimethoxyphenoxy)benzoic Acid

Lee, K., Ho, W., Wu, S.-J., Omar, H. A., Huang, P.-J., Wang, C. C. C., & Hung, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15010743 · Cited by 12

E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation

Carcagno, A. L., Giono, L. E., Marazita, M. C., Castillo, D., Pregi, N., & Cánepa, E. T. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1289-8 · Cited by 11

Salvia chinensis Benth Inhibits Triple-Negative Breast Cancer Progression by Inducing the DNA Damage Pathway

Wang, K., Hu, Y., Han, L.-L., Zhao, S., Song, C., Sun, S.-W., Lv, H.-Y., Jiang, N.-N., Xv, L.-Z., Zhao, Z.-W., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.882784 · Cited by 10

Lack of Associations of the MDM4 rs4245739 Polymorphism with Risk of Thyroid Cancer among Iranian-Azeri Patients: a Case-Control Study

Khanlou, Z. M., Pouladi, N., Feizi, M. A. H., & Pedram, N. (2017) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2017.18.4.1133 · Cited by 10

Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study

Maruei‐Milan, R., Heidari, Z., & Salimi, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27960 · Cited by 10

Effects of deranged metabolism on epigenetic changes in cancer

Chandra, V., & Hong, K. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0561-3 · Cited by 11

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

Ristau, J., van Hoef, V., Peuget, S., Zhu, J., Guan, B., Liang, S., Hatzoglou, M., Topisirović, I., Selivanova, G., & Larsson, O. S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2074-3 · Cited by 10

Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication

Deng, Z., Sun, R., Han, X. M., Zhang, Y., Zhou, Y., Shan, Y., Xu, J., Li, X., He, F., & Fang, W. (2022) · Journal of Virology · doi:10.1128/jvi.01274-22 · Cited by 9

RUNX2 Reverses p53-Induced Chemotherapy Resistance in Gastric Cancer

Huang, Y., Liang, L., Zhao, Y.-X., Yao, B., Zhang, R., Song, L., & Zhang, Z. (2023) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s394393 · Cited by 9

A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis

Hirano, T., Murakami, T., Ono, H., Sakurai, A., Tominaga, T., Takahashi, T., Nagai, K., Doi, T., & Abe, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133205 · Cited by 9

Merkel cell carcinoma. A review

Pink, R., Ehrmann, J., Molitor, M., Tvrdý, P., Michl, P., Pazdera, J., & Hanuliak, J. (2012) · Biomedical Papers · doi:10.5507/bp.2012.033 · Cited by 9

The Impact Of CDK Inhibition In Human Malignancies Associated With Pronounced Defects In Apoptosis: Advantages Of Multi-Targeting Small Molecules

Węsierska‐Gądek, J., & Kramer, M. P. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.12 · Cited by 8

p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B

Di, J., Tang, J., Qian, H., Franklin, D. A., Deisenroth, C., Itahana, Y., Zheng, J., & Zhang, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.18112 · Cited by 9

Acute alcohol consumption-induced let-7a inhibition exacerbates hepatic apoptosis by regulating Rb1 in mice

Pan, J. H., Kim, H., Tang, J., Beane, K. E., Park, J., Kong, S., Kong, B. C., Kim, Y. J., Shin, E., Kim, J. H., et al. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.10.008 · Cited by 9

Effects of low‑dose bufalin combined with hydroxycamptothecin on human castration‑resistant prostate cancer xenografts in nude mice

Gu, R., & Zhang, Q. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10447 · Cited by 9

Development of a fluorescence reporter system to quantify transcriptional activity of endogenous p53 in living cells

Tsuruoka, T., Nakayama, E., Endo, T., Harashima, S., Kamada, R., Sakaguchi, K., & Imagawa, T. (2023) · Journal of Cell Science · doi:10.1242/jcs.260918 · Cited by 11

Ochratoxin A-induced DNA damage triggers G2 phase arrest via hMLH1-p53-p21 signaling pathway in human gastric epithelium immortalized cells in vitro

Jia, X., Wang, Y., Cui, J., Li, Y., Wu, W., Zhang, X., & Wang, J. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.08.005 · Cited by 8

Genome Maintenance Mechanisms at the Chromatin Level

Takatsuka, H., Shibata, A., & Umeda, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910384 · Cited by 8

Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium

Li, T., Zheng, Y., Li, T., Guo, M. Z., Wu, X., Liu, R., Liu, Q., You, X., Zeng, W., & Lv, Y. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.05.009 · Cited by 8

Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

Ki, M., Lee, H.-R., Park, J., Hong, I., Han, S., You, S., Lee, E.-M., Kim, A.-Y., Lee, S., & Jeong, K. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.04.008 · Cited by 8

Future Aspects of Tumor Suppressor Gene

Cheng, Y. (2013) · InTech eBooks · doi:10.5772/56471 · Cited by 8

Selective cytotoxicity and modulation of apoptotic signature of breast cancer cells by P ithecellobium dulce leaf extracts

Sharma, M. (2016) · Biotechnology Progress · doi:10.1002/btpr.2261 · Cited by 8

Synthesis and structural characterization of antimicrobial binuclear copper(II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

Buchtelová, H., Škubalová, Z., Strmiska, V., Michálek, P., Kočiová, S., Šmerková, K., Kruszyński, R., Bieńko, A., Kaj, M., Lewińska, A., et al. (2018) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2018.10.011 · Cited by 8

Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients

Bauer, M., Kantelhardt, E. J., Stiewe, T., Nist, A., Mernberger, M., Politt, K., Hanf, V., Lantzsch, T., Uleer, C., Peschel, S., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.26768 · Cited by 8

A multi-modal proteomics strategy for characterizing posttranslational modifications of tumor suppressor p53 reveals many sites but few modified formsPreprint

DeHart, C. J., Fornelli, L., Anderson, L. C., Fellers, R. T., Lü, D., Hendrickson, C. L., Lahav, G., Gunawardena, J., & Kelleher, N. L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/455527 · Cited by 8

Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells

Jung, B. C., Kim, S. H., Cho, Y., & Kim, Y. S. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0134 · Cited by 7

Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis and signaling to its downstream effectors

Dance-Barnes, S. T., Kock, N. D., Floyd, H. S., Moore, J. E., Mosley, L. J., D'Agostino, R. B., Pettenati, M. J., & Miller, M. S. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.04.014 · Cited by 7

Design, Synthesis and Biological Evaluation of Novel 5‐Phenyl‐5‐(thiophen‐2‐yl)‐4 H ‐1,2,4‐triazole‐3‐thiols as an Anticancer Agent

Patel, K. R., Brahmbhatt, J., Pandya, P. A., Bhadresha, K. P., Daraji, D. G., Patel, H. D., Rawal, R., Baran, S. K., & Jayanthi, S. (2021) · ChemistrySelect · doi:10.1002/slct.202100025 · Cited by 7

Mechanism of andrographis paniculata on lung cancer by network pharmacology and molecular docking

Li, J., Liu, X., Li, J., Han, D., Li, Y., & Ge, P. (2023) · Technology and Health Care · doi:10.3233/thc-220698 · Cited by 7

High SGO2 Expression Predicts Poor Overall Survival: A Potential Therapeutic Target for Hepatocellular Carcinoma

Deng, M., Li, S., Mei, J., Lin, W., Zou, J., Wei, W., & Guo, R. (2021) · Genes · doi:10.3390/genes12060876 · Cited by 7

Protein kinase C downregulation induces senescence via FoxO3a inhibition in HCT116 and HEK293 cells

Park, J., Lee, Y., & Bae, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.021 · Cited by 7

Kidney targeted delivery of siRNA mediated by peptide-siRNA conjugate for the treatment of acute kidney injury

Yuan, M., Hu, X., Li, N., Xu, L., Zhu, M., Pei, X., Li, R., Sun, L., Chen, Y., Yu, F., et al. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110251 · Cited by 6

Affinity-based protein profiling of MDM2 inhibitor Navtemadlin

Date, A., Wall, A., Zhang, P., Houghton, J. W., Lu, J., Thomas, A., Kovačič, T., Wilson, A. J., Tate, E. W., & Barnard, A. (2025) · Chemical Science · doi:10.1039/d5sc00120j · Cited by 6

Regulators mount up: the metabolic roles of apoptotic proteins

Schofield, J. H., & Schafer, Z. T. (2023) · Frontiers in Cell Death · doi:10.3389/fceld.2023.1223926 · Cited by 6

Clinical and pathological correlation of P53 expression in oral cancers

Bellala, R., Bellala, V. M., Kalagara, A., Bodepudi, S., Harnadh, S., Bindu, P., Pydi, V. R., Raj, B. P., Nitya, G., & Bellala, R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155071 · Cited by 6

Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression

Marruecos, L., Manils, J., Moreta-Moraleda, C., Gómez, D., Filgaira, I., Serafín, A., Cañas, X., Espinosa, L., & Soler, C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03638-3 · Cited by 6

The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition

Stieg, D. C., Parris, J. L. D., Yang, T. H. L., Mirji, G., Reiser, S. K., Murali, N., Werts, M., Barnoud, T., Lu, D. Y., Shinde, R. S., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0149 · Cited by 6

Overexpression of renal proapoptotic factors is attenuated subsequent to endurance exercise in Type I diabetes: An immunohistochemistry study

Erekat, N. S., Rababa'h, R., & Al-Jarrah, M. D. (2019) · Journal of Natural Science Biology and Medicine · doi:10.4103/jnsbm.jnsbm_60_18 · Cited by 6

Integration of IgG and IgA autoantibodies for early diagnosis of hepatocellular carcinoma

Yang, T., Lin, X., Zhang, L., Yu, L., Wu, Q., Zhang, S., Qiu, F., & Huang, Y. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.10.037 · Cited by 6

The Effect of p53 Status on Radio-Sensitivity of Quiescent Tumor Cell Population Irradiated With γ-Rays at Various Dose Rates

Masunaga, S., Kobayashi, J., Tano, K., Sanada, Y., Suzuki, M., & Ono, K. (2018) · Journal of Clinical Medicine Research · doi:10.14740/jocmr3610w · Cited by 6

Comprehensive analysis of mode of action for cadmium-induced renal tubular dysfunction: a case study integrating high-throughput sequencing, targeted cellular assays, and human data

Xu, F., Li, Z., Lai, Y.-F., Meng-Zhou, Zhao, X.-H., Mo, L.-H., Wan, S.-Y., Chen, L., Luo, X.-Y., Wu, W., et al. (2025) · Environment International · doi:10.1016/j.envint.2025.109744 · Cited by 5

RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts

O’Byrne, A. M., de Jong, T. A., Semmelink, J. F., Krawczyk, P. M., Hoebe, R. A., van de Sande, M. G. H., & van Baarsen, L. G. M. (2026) · RMD Open · doi:10.1136/rmdopen-2025-005774 · Cited by 5

An essential role for Cmtr2 in mammalian embryonic development

Yermalovich, A. V., Mohsenin, Z., Cowdin, M. A., Giotti, B., Gupta, A. A., Feng, A., Golomb, L., Wheeler, D. B., Xu, K., Tsankov, A. M., et al. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2024.07.019 · Cited by 5

Role of artificial intelligence in cancer detection using protein p53: A Review

Patil, M. R., & Bihari, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10051-4 · Cited by 6

ID3 is a novel target gene of p53 and modulates lung cancer cell metastasis

Nagasaka, M., Miyajima, C., Inoue, Y., Hashiguchi, S., Suzuki, Y., Morishita, D., Aoki, H., Toriuchi, K., Katayama, R., Aoyama, M., et al. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149789 · Cited by 5

Dulaglutide reduces oxidative DNA damage and hypermethylation in the somatic cells of mice fed a high‐energy diet by restoring redox balance, inflammatory responses, and DNA repair gene expressions

Attia, S. M., Alshamrani, A. A., Ahmad, S. F., Albekairi, N. A., Nadeem, A., Attia, M. S. M., Ansari, M. A., Almutairi, F., & Bakheet, S. A. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23764 · Cited by 5

Analysis of the functional integrity of the p53 tumor-suppressor gene in malignant melanoma

Knopf, A., Plettenberg, C., Pickhard, A., Bas, M., Reifenberger, J., Bier, H., & Balz, V. (2011) · Melanoma Research · doi:10.1097/cmr.0b013e328347ee04 · Cited by 5

Potential biological process of X‑linked inhibitor of apoptosis protein in renal cell carcinoma based upon differential protein expression analysis

Chen, C., Zhao, S., Yang, W. Z., Chen, Z. P., & Yan, Y. (2017) · Oncology Letters · doi:10.3892/ol.2017.7383 · Cited by 5

A chimeric protein PTEN-L-p53 enters U251 cells to repress proliferation and invasion

Xiao, M., An, Y., Wang, F., Yao, C., Zhang, C., Xin, J., Duan, Y., Zhao, X., Fang, N., & Ji, S. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.05.023 · Cited by 5

Transcription of genes of p53-dependent apoptosis in acute leukaemia

Racay (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000092 · Cited by 5

Portrait of Transcriptional Expression Profiles Displayed by Different Glioblastoma Cell Lines

Godoy, P. R. D. V., Stephano, S., Daniele, A., Flavia, S., Ana, P., Nicolucci, P., Eduardo, A., Passos, G. A. S., & Elza, T. (2011) · InTech eBooks · doi:10.5772/22322 · Cited by 4

Recombinant human p53 adenovirus injection combined with Bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma

Wang, Q., Shi, Q., Chen, Y., Wang, G. G., & Shen, L. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107041 · Cited by 4

ECRG2/SPINK7 Tumor Suppressor as Modulator of DNA Damage Response

Patel, H., Sheikh, M. S., & Huang, Y. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115854 · Cited by 4

Serum anti-p53 antibody as a tumour marker for colorectal cancer screening

Iwamuro, M., Kawai, Y., Matsumoto, T., Uda, M., & Okada, H. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.560 · Cited by 4

Bringing p53 into the Clinic

Cheok, C. F. (2014) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000294 · Cited by 5

Cell Cycle Checkpoints and Senescence

Wadhwa, R., Kaul, Z., & Kaul, S. C. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_9 · Cited by 4

Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers

Siddik, Z. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-89445-4_9 · Cited by 4

Unravelling mechanisms of p53-mediated tumour suppression

Bieging-Rolett, K. T., Mello, S. S., & Attardi, L. D. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3711 · Cited by 1,459

p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities

Giono, L. E., Ladelfa, M. F., & Monte, M. (2014) · Springer eBooks · doi:10.1007/978-94-017-9421-3_4

Activation of the p53 tumor suppressor protein

Vousden, K. H. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00035-5 · Cited by 337

Activation and activities of the p53 tumour suppressor protein

Bálint, É., & Vousden, K. H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2128 · Cited by 315

Regulation of the p53 response and its relationship to cancer

Meek, D. W. (2015) · Biochemical Journal · doi:10.1042/bj20150517 · Cited by 311