Coping with stress: multiple ways to activate p53

Surfing the p53 network

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CDK inhibitors: positive and negative regulators of G1-phase progression

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Cell Death

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

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Mitochondrial dynamics regulating chemoresistance in gynecological cancers

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Molecular Mechanisms of Anticancer Activities of Puerarin

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Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues

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Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types

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Autophagy regulation in cancer development and therapy.

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Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53

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Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells

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Merkel cell carcinoma

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Merkel cell carcinoma: molecular pathogenesis, clinical features and therapy

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USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

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Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7

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Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer

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Chlorpyrifos Induction of Testicular-Cell Apoptosis through Generation of Reactive Oxygen Species and Phosphorylation of AMPK

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Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivityPreprint

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Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

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New frontiers in cell competition†

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Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53

Potapova, T., Seidel, C. W., Box, A., Rancati, G. I., & Li, R. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-05-0268 · Cited by 68

Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities

Zhang, Y., Huang, Y., Li, Z., Wu, H., Zou, B., & Xu, Y. H. (2023) · Cancers · doi:10.3390/cancers15143585 · Cited by 70

A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization

Pereboom, T. C., van Weele, L. J., Bondt, A., & MacInnes, A. W. (2011) · Blood · doi:10.1182/blood-2011-04-351460 · Cited by 69

Reactive oxygen species mediate Terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and pro-apoptotic proteins

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New Perspectives in Cancer Therapy: The Biotin-Antitumor Molecule Conjugates

Collina, S. (2014) · Medicinal Chemistry · doi:10.4172/2161-0444.s1-004 · Cited by 70

Molecular characterization of human homologs of yeast MOB1

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Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

Ding, S.-L., & Shen, C. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s1957 · Cited by 74

Regulation of the p53 pathway by ubiquitin and related proteins

Hock, A., & Vousden, K. H. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.06.011 · Cited by 70

The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2

Guaragnella, N., Palermo, V., Galli, A., Moro, L., Mazzoni, C., & Giannattasio, S. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12094 · Cited by 75

Inverted repeatAluelements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function

Chillón, I., & Pyle, A. M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw599 · Cited by 67

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

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Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 inCaenorhabditis elegans

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Evidence for a Role of ANAC082 as a Ribosomal Stress Response Mediator Leading to Growth Defects and Developmental Alterations in Arabidopsis

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Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress

Hanson, R. L., & Batchelor, E. (2022) · Molecular Systems Biology · doi:10.15252/msb.202211401 · Cited by 60

TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer

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Deficient TP53 Expression, Function, and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer

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Normal and cancer cell metabolism: lymphocytes and lymphoma

Altman, B. J., & Dang, C. V. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08651.x · Cited by 66

Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress

Ahuja, D., Goyal, A., & Ray, P. S. (2016) · RNA Biology · doi:10.1080/15476286.2016.1229734 · Cited by 62

Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond

Brown-Suedel, A. N., & Bouchier‐Hayes, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.610022 · Cited by 62

Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway

Guo, Z., Hu, G., Wang, H., Li, Z., & Liu, N. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.136 · Cited by 64

Restoring p53 Function in Head and Neck Squamous Cell Carcinoma to Improve Treatments

de Bakker, T., Journé, F., Descamps, G., Saussez, S., Dragan, T., Ghanem, G., Krayem, M., & Gestel, D. V. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.799993 · Cited by 64

Making sense of ubiquitin ligases that regulate p53

Jain, A. K., & Barton, M. C. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.7.13445 · Cited by 60

Clinical utility of anti-p53auto-antibody: Systematic review and focus on colorectal cancer

Suppiah, A. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i29.4651 · Cited by 62

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

Mai, Y., Yu, J., Bartholdy, B., Xu-Monette, Z. Y., Knapp, E. E., Yuan, F., Chen, H., Ding, B. B., Yao, Z., Das, B. C., et al. (2016) · Blood · doi:10.1182/blood-2016-03-705814 · Cited by 57

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells

Norden, E., & Heiß, E. H. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy158 · Cited by 59

A synthetic–natural hybrid oscillator in human cells

Toettcher, J. E., Mock, C. S., Batchelor, E., Loewer, A., & Lahav, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005615107 · Cited by 57

Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure

Liu, S., Kim, T.-H., Franklin, D. A., & Zhang, Y. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.086 · Cited by 57

Prion-like p53 Amyloids in Cancer

Navalkar, A., Ghosh, S., Pandey, S., Paul, A., Datta, D., & Maji, S. K. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00796 · Cited by 56

Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2

García‐Cano, J., Sánchez‐Tena, S., Sala-Gaston, J., Figueras, A., Viñals, F., Bartrons, R., Ventura, F., & Rosa, J. L. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12592 · Cited by 60

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

Birts, C. N., Banerjee, A., Darley, M., Dunlop, C. R., Nelson, S., Nijjar, S. K., Parker, R., West, J. J., Tavassoli, A., Rose-Zerilli, M. J. J., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aau9529 · Cited by 56

Chromatin Immunoprecipitation–on-Chip Reveals Stress-Dependent p53 Occupancy in Primary Normal Cells but Not in Established Cell Lines

Shaked, H., Shiff, I., Kott-Gutkowski, M., Siegfried, Z., Haupt, Y., & Simon, I. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0865 · Cited by 57

Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response

Weiss, M. B., Vitolo, M. I., Mohseni, M., Rosen, D. M., Denmeade, S. R., Park, B. H., Weber, D. J., & Bachman, K. E. (2010) · Oncogene · doi:10.1038/onc.2010.220 · Cited by 54

OTUD5 Regulates p53 Stability by Deubiquitinating p53

Luo, J., Lu, Z., Lu, X., Chen, L., Cao, J., Zhang, S., Yang, L., & Zhou, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077682 · Cited by 56

The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response

Koeppel, M., van Heeringen, S. J., Smeenk, L., Navis, A. C., Janssen‐Megens, E. M., & Lohrum, M. A. E. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn940 · Cited by 57

Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice

Jung, C., Lim, J. H., Choi, Y., Kim, D., Kang, K. J., Noh, S., & Im, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42674 · Cited by 56

Modulation of oncogenic transcription factors by bioactive natural products in breast cancer

Hasanpourghadi, M., Pandurangan, A. K., & Mustafa, M. R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.09.009 · Cited by 55

Plant Nucleolar Stress Response, a New Face in the NAC-Dependent Cellular Stress Responses

Ohbayashi, I., & Sugiyama, M. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2017.02247 · Cited by 52

Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1,4,5-trisubstituted 1,2,3-triazoles derivatives as elevators of p53 protein levels

Ibrahim, Z. Y., Uzairu, A., Shallangwa, G. A., & Abechi, S. E. (2020) · Scientific African · doi:10.1016/j.sciaf.2020.e00570 · Cited by 55

Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals

Erol, A. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.11.023 · Cited by 56

Cyclometallated iridium complexes inducing paraptotic cell death like natural products: synthesis, structure and mechanistic aspects

Tripathy, S. K., De, U., Dehury, N., Laha, P., Panda, M. K., Kim, H. S., & Patra, S. (2016) · Dalton Transactions · doi:10.1039/c6dt00929h · Cited by 54

The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage

Dörsam, B., Wu, C., Efferth, T., Kaina, B., & Fahrer, J. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1281-z · Cited by 53

Modifications of p53: competing for the lysines

Carter, S., & Vousden, K. H. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.11.010 · Cited by 57

Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

Hanashiro, K., Kanai, M., Geng, Y., Siciński, P., & Fukasawa, K. (2008) · Oncogene · doi:10.1038/onc.2008.161 · Cited by 55

The p53-p21Cip1/WAF1 Pathway Is Necessary for Cellular Senescence Induced by the Inhibition of Protein Kinase CKII in Human Colon Cancer Cells

Kang, J., Kim, J. J., Jang, S. Y., & Bae, Y. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0141-9 · Cited by 51

Manipulation of Gene Expression by Oxygen: A Primer From Bedside to Bench

Wright, C. J., & Dennery, P. A. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e3181a2c184 · Cited by 50

A p38MAPK/HIF-1 Pathway Initiated by UVB Irradiation Is Required to Induce Noxa and Apoptosis of Human Keratinocytes

Nys, K., Laethem, A. V., Michiels, C., Rubio, N., Piette, J. G., Garmyn, M., & Agostinis, P. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.93 · Cited by 49

Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress

Robin, M., Issa, A.-R., Santos, C. C., Napoletano, F., Petitgas, C., Chatelain, G., Ruby, M., Walter, L., Birman, S., Domingos, P. M., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1558001 · Cited by 49

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

Seiwert, N., Neitzel, C., Stroh, S., Frisan, T., Audebert, M., Toulany, M., Kaina, B., & Fahrer, J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.418 · Cited by 54

p53 dynamics orchestrates with binding affinity to target genes for cell fate decision

Wu, M., Ye, H., Tang, Z., Shao, C., Lu, G., Chen, B., Yang, Y., Wang, G., & Hao, H. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.492 · Cited by 49

Dietary citric acid supplementation alleviates soybean meal-induced intestinal oxidative damage and micro-ecological imbalance in juvenile turbot,Scophthalmus maximusL

Chen, Z., Zhao, S., Liu, Y., Yang, P., Ai, Q., Zhang, W., Xu, W., Zhang, Y., Zhang, Y., & Mai, K. (2018) · Aquaculture Research · doi:10.1111/are.13847 · Cited by 49

The role of p38 MAPK pathway in p53 compromised state and telomere mediated DNA damage response

Roy, S., Roy, S., Rana, A., Akhter, Y., Hande, M. P., & Banerjee, B. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.05.018 · Cited by 48

Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage

Guha, A., Ahuja, D., Mandal, S. D., Parasar, B., Deyasi, K., Roy, D., Sharma, V., Willard, B. B., Ghosh, A., & Ray, P. S. (2019) · iScience · doi:10.1016/j.isci.2019.05.002 · Cited by 47

Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma

Southgate, H. E. D., Chen, L., Curtin, N. J., & Tweddle, D. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00371 · Cited by 48

MDM2-p53 in liposarcoma: The need for targeted therapies with novel mechanisms of action

Somaiah, N., & Tap, W. D. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102668 · Cited by 45

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil

Dörsam, B., Göder, A., Seiwert, N., Kaina, B., & Fahrer, J. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1434-0 · Cited by 49

CARF Is a Vital Dual Regulator of Cellular Senescence and Apoptosis

Hasan, M. K., Cheung, C., Kaul, Z., Shah, N., Sakaushi, S., Sugimoto, K., Oka, S., Kaul, S. C., & Wadhwa, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805778200 · Cited by 45

Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)

Lin, X., Xiao, W., Xiao, L., & Liu, M. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9028 · Cited by 44

The role of microRNA-34 family in Alzheimer’s disease: A potential molecular link between neurodegeneration and metabolic disorders

Bazrgar, M., Khodabakhsh, P., Prudencio, M., Mohagheghi, F., & Ahmadiani, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105805 · Cited by 45

Suppression of p53 activity by Siva1

Du, W., Jiang, P., Li, N., Mei, Y., Wang, X., Wen, L., Yang, X., & Wu, M. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.89 · Cited by 44

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Allison, S. J., Bryk, J., Clemett, C. J., Faulkner, R. A., Ginger, M. L., Griffiths, H. B. S., Harmer, J., Owen‐Lynch, P. J., Pinder, E., Wurdak, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23983-3 · Cited by 42

The crisscross between p53 and metabolism in cancer

Mao, Y., & Jiang, P. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023109 · Cited by 45

C/EBPβ represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19Arf

Ewing, S. J., Zhu, S., Zhu, F., House, J. S., & Smart, R. C. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.105 · Cited by 41

A p53-Pax2 Pathway in Kidney Development: Implications for Nephrogenesis

Saifudeen, Z. R., Liu, J., Dipp, S., Yao, X., Li, Y., McLaughlin, N., Aboudehen, K., & El-Dahr, S. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044869 · Cited by 42

Epirubicin Upregulates UDP Glucuronosyltransferase 2B7 Expression in Liver Cancer Cells via the p53 Pathway

Hu, D. G., Rogers, A., & Mackenzie, P. I. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.091603 · Cited by 42

Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury

Tang, W., Chen, Y., Jang, H., Yu, H., Jogdeo, C. M., Li, J., Ding, L., Zhang, C., Yu, A., Yu, F., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.029 · Cited by 42

The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish

Paridaen, J. T. M. L., Janson, E., Utami, K. H., Pereboom, T. C., Essers, P., van Rooijen, C., Živković, D., & MacInnes, A. W. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.028 · Cited by 42

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

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Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins

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