Cited by 524Cancer-related Molecular PathwaysCell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

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Coping with stress: multiple ways to activate p53

Horn, H F, Vousden, K H·2007·Oncogene

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Abstract

Over the years, p53 has been shown to sit at the centre of an increasingly complex web of incoming stress signals and outgoing effector pathways. The number and diversity of stress signals that lead to p53 activation illustrates the breadth of p53's remit - responding to a wide variety of potentially oncogenic insults to prevent tumour development. Interestingly, different stress signals can use different and independent pathways to activate p53, and there is some evidence that different stress signals can mediate different responses. How each of the responses to p53 contributes to inhibition of malignant progression is beginning to be clarified, with the hope that identification of responses that are key to tumour suppression will allow a more focused and effective search for new therapeutic targets. In this review, we will highlight some recently identified roles for p53 in tumour suppression, and discuss some of the numerous mechanisms through which p53 can be regulated and activated.

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Authors: Horn, H. F., & Vousden, K. H.
Affiliations: Cancer Research UK Scotland Institute (GB)
Corresponding author: Vousden, K H
ORCID: Horn, H F
Vousden, K H
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2007-02-26
Volume: 26
Issue: 9
Pages: 1306-1316
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1210263
OpenAlex: W2035188342
Semantic Scholar: ea46e0441d9175c80c0ddbd29c6fc13c60a82939
Cited by: 522
References: 167
Citations by year: 2026: 5 · 2025: 6 · 2024: 18 · 2023: 22 · 2022: 20 · 2021: 30 · 2020: 23 · 2019: 27 · 2018: 35 · 2017: 37 · 2016: 35 · 2015: 30 · 2014: 26 · 2013: 36 · 2012: 26
FWCI: 3.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: p53, stress signals, p53 activation, tumor suppression, stress response pathways, malignant progression, therapeutic target
MeSH terms: Humans, Neoplasms, Signal Transduction, Tumor Suppressor Protein p53, Oxidative Stress

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Coping with stress: multiple ways to activate p53

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