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CDK inhibitors: positive and negative regulators of G1-phase progression

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Cell Death

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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Redox regulation of cell survival

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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

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Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

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Census and evaluation of p53 target genes

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p53 and metabolism

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Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

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p53 Dynamics Control Cell Fate

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Merkel cell carcinoma

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A hyperfused mitochondrial state achieved at G 1 –S regulates cyclin E buildup and entry into S phase

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p53 post-translational modification: deregulated in tumorigenesis

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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

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Metabolic Regulation by p53 Family Members

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Are Structural Analogues to Bisphenol A Safe Alternatives?

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p53 modifications: exquisite decorations of the powerful guardian

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16 INK4a lossPreprint

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Sp1: Emerging roles—Beyond constitutive activation of TATA-less housekeeping genes

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Stimulus‐dependent dynamics of p53 in single cells

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The multiple levels of regulation by p53 ubiquitination

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The rebel angel: mutant p53 as the driving oncogene in breast cancer

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Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening

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5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

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Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

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The complexity of p53-mediated metabolic regulation in tumor suppression

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A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

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Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

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Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.

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The ups and downs of p53: understanding protein dynamics in single cells

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The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

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Surf the Post-translational Modification Network of p53 Regulation

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The in vivo gene expression signature of oxidative stress

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Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway

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Deconstructing networks of p53-mediated tumor suppression in vivo

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The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis

Potapova, T., & Gorbsky, G. J. (2017) · Biology · doi:10.3390/biology6010012 · Cited by 238

Relevance of the p53–MDM2 axis to aging

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miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

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20 years studying p53 functions in genetically engineered mice

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HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

Sendoel, A., Köhler, I., Fellmann, C., Lowe, S. W., & Hengartner, M. O. (2010) · Nature · doi:10.1038/nature09141 · Cited by 191

Characterization of genome-wide p53-binding sites upon stress response

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Cancer and ageing: convergent and divergent mechanisms

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p53 Regulation of Metabolic PathwaysPreprint

Gottlieb, E., & Vousden, K. H. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001040 · Cited by 189

SnapShot: p53 Posttranslational Modifications

Kruse, J.-P., & Gu, W. J. (2008) · Cell · doi:10.1016/j.cell.2008.05.020 · Cited by 183

Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos

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Emerging Disinfection Byproducts, Halobenzoquinones: Effects of Isomeric Structure and Halogen Substitution on Cytotoxicity, Formation of Reactive Oxygen Species, and Genotoxicity

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The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

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Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

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Biotin conjugated organic molecules and proteins for cancer therapy: A review

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Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

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Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer

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Merkel cell carcinoma

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Another fork in the road—life or death decisions by the tumour suppressor p53

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Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

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Regulation of Cellular Metabolism and Hypoxia by p53Preprint

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Genetics and Epigenetics of Human Retinoblastoma

Benavente, C. A., & Dyer, M. A. (2015) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040259 · Cited by 143

Radioprotective Agents: Strategies and Translational Advances

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The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

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Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs

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The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria

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Induction of SOX4 by DNA damage is critical for p53 stabilization and function

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Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3

Aziz, M. H., Shen, H., & Maki, C. G. (2011) · Oncogene · doi:10.1038/onc.2011.185 · Cited by 131

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

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Cell Cycle Regulation by the Nutrient-Sensing Mammalian Target of Rapamycin (mTOR) Pathway

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Mdm2 Induces Mono-Ubiquitination of FOXO4

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P53 in kidney injury and repair: Mechanism and therapeutic potentials

Tang, C., Ma, Z., Zhu, J., Liu, Z., Liu, Y., Liu, Y., Cai, J., & Dong, Z. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.10.013 · Cited by 121

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

Hock, A. K., Vigneron, A. M., Carter, S., Ludwig, R. L., & Vousden, K. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.419 · Cited by 117

Spotlight on the role of COP1 in tumorigenesis

Marine, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3271 · Cited by 120

Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells

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p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Fox, D. K., Ebert, S. M., Bongers, K. S., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Kunkel, S. D., & Adams, C. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2014 · Cited by 125

P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?

Szybińska, A., & Leśniak, W. (2017) · Aging and Disease · doi:10.14336/ad.2016.1120 · Cited by 118

Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo

Feng, W., Jiang, X. M., Gao, H., & Gao, S. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4134 · Cited by 115

SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro

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Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

Sanchez‐Macedo, N., Feng, J., Faubert, B., Chang, N., Elia, A., Rushing, E. J., Tsuchihara, K., Bungard, D., Berger, S. L., Jones, R. G., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2012.168 · Cited by 117

Nucleolar stress: From development to cancer

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Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells

Huang, C., Yang, M., Deng, J., Li, P., Su, W., & Jiang, R. (2018) · Oncology Reports · doi:10.3892/or.2018.6585 · Cited by 106

SUMOylation of hnRNP‐K is required for p53‐mediated cell‐cycle arrest in response to DNA damage

Lee, S. W., Lee, M. H., Park, J. H., Kang, S. H., Yoo, H. M., Ka, S. H., Oh, Y. M., Jeon, Y. J., & Chung, C. H. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.293 · Cited by 106

Molecular pathogenesis of Merkel cell carcinoma

Houben, R., Schrama, D., & Becker, J. C. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00853.x · Cited by 101

Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?

Thomas, A., Kelly, G. L., & Strasser, A. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00996-z · Cited by 102

Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma

Herrero, A. B., Rojas, E. A., Misiewicz-Krzemińska, I., Krzemiński, P., & Gutierrez, N. C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122003 · Cited by 102

Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells

Yuan, L., Zhang, Y., XIA, J., Liu, B., ZHANG, Q., LIU, J., Luo, L., Zhou, P., Song, Z., & Zhu, R. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3100 · Cited by 98

Mouse Models of p53 FunctionsPreprint

Lozano, G. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001115 · Cited by 97

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4Preprint

Perry, M. E. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000968 · Cited by 100

Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos

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STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy

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Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells

Zhu, Y., He, W., Gao, X., Li, B., Mei, C., Xu, R., & Chen, H. (2015) · Scientific Reports · doi:10.1038/srep17730 · Cited by 91

Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus

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Hyperoxia Impairs Alveolar Formation and Induces Senescence Through Decreased Histone Deacetylase Activity and Up-Regulation of p21 in Neonatal Mouse Lung

Londhe, V. A., Sundar, I. K., Lopez, B. J., Maisonet, T. M., Yu, Y., Aghai, Z. H., & Rahman, I. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318211c917 · Cited by 89

Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest

Zhang, F., Wang, W., Tsuji, Y., Torti, S. V., & Torti, F. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806432200 · Cited by 90

Crystal structure of a p53 core tetramer bound to DNA

Malecka, K. A., Ho, W. C., & Marmorstein, R. (2008) · Oncogene · doi:10.1038/onc.2008.400 · Cited by 87

p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

McNamee, L. M., & Brodsky, M. H. (2009) · Genetics · doi:10.1534/genetics.109.102327 · Cited by 89

Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

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Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes

Brunkard, J. O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.022 · Cited by 89

Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population

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Dysfunction of the MDM2/p53 axis is linked to premature aging

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