Differential regulation and properties of MAPKs

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,400

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266

Protein Tyrosine Phosphatases in the Human Genome

Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T. (2004) · Cell · doi:10.1016/j.cell.2004.05.018 · Cited by 1,886

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886

Signal Transduction through MAP Kinase Cascades

Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759

In vivo and in vitro inhibition of human liver cancer progress by downregulation of the μ-opioid receptor and relevant mechanisms

Jin, L., Liu, Z., Zhao, L., Tian, H., Liu, X., & YUAN, C. (2013) · Oncology Reports · doi:10.3892/or.2013.2640 · Cited by 32

β,β-Dimethylacrylshikonin Induces Mitochondria Dependent Apoptosis through ERK Pathway in Human Gastric Cancer SGC-7901 Cells

Shen, X., Wang, H., Ma, X., & Chen, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041773 · Cited by 30

Neuroprotective effects of ginsenosides Rh1 and Rg2 on neuronal cells

Li, X., Lui, C. N. P., Jiang, Z., & Yung, K. K. L. (2011) · Chinese Medicine · doi:10.1186/1749-8546-6-19 · Cited by 30

ERK‐1 MAP kinase prevents TNF‐induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells

Pucci, B., Indelicato, M., Paradisi, V., Reali, V., Pellegrini, L., Aventaggiato, M., Karpinich, N. O., Fini, M., Russo, M. A., Farber, J. L., et al. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22345 · Cited by 30

Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

Matsumoto, T., Kinoshita, T., Matsuzaka, H., Nakai, R., Kirii, Y., YOKOTA, K., & Tada, T. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs023 · Cited by 31

Perfluorooctanoic acid induces human Ishikawa endometrial cancer cell migration and invasion through activation of ERK/mTOR signaling

Ma, Z., Liu, X., Li, F., Wang, Y., Xu, Y. Y., Zhang, M., Zhang, X., Ying, X., & Zhang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.11684 · Cited by 31

ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway

Huang, X., Yu, P., Liu, M., Deng, Y., Dong, Y., Liu, Q., Zhang, J., & Wu, T. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.11.031 · Cited by 30

Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma

Xu, Z., Fu, W., Jin, Z., Guo, P., Wang, W., & Li, J. (2015) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1061127 · Cited by 29

Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche

Mills, B. N., Albert, G. P., & Halterman, M. W. (2017) · Cancer Microenvironment · doi:10.1007/s12307-017-0197-6 · Cited by 29

High glucose exacerbates neuroinflammation and apoptosis at the intermediate stage after post-traumatic brain injury

Zhang, W., Hong, J., Zheng, W., Liu, A., & Yang, Y. (2021) · Aging · doi:10.18632/aging.203136 · Cited by 29

ERK-mediated upregulation of matrix metalloproteinase-2 promotes the invasiveness in human oral squamous cell carcinoma (OSCC)

Pramanik, K. K., & Mishra, R. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112984 · Cited by 29

The zinc transporter ZIP12 regulates monocrotaline-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/ERK signaling pathways

Ye, C., Lian, G., Wang, T., Chen, A., Chen, W., Gong, J., Luo, L., Wang, H., & Xie, L. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-01905-3 · Cited by 29

Quantifying membrane permeability of amphotericin B ion channels in single living cells

Yang, T., Ou, K., Peng, P., Liou, B.-C., Wang, W., Huang, Y.-C., Tsai, C., & Su, C. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.03.021 · Cited by 29

Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet β-Cells

Nishiki, Y., Adewola, A. F., Hatanaka, M., Templin, A. T., Maier, B., & Mirmira, R. G. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1230 · Cited by 29

Mitogen‐activated protein kinase p38 regulates krox‐20 to direct schwann cell differentiation and peripheral myelination

Hossain, S., de la Cruz-Morcillo, M. Á., Sánchez‐Prieto, R., & Almazán, G. (2012) · Glia · doi:10.1002/glia.22340 · Cited by 29

PPE38 of Mycobacterium marinum Triggers the Cross-Talk of Multiple Pathways Involved in the Host Response, As Revealed by Subcellular Quantitative Proteomics

Wang, H., Dong, D., Tang, S., Chen, X., & Gao, Q. (2013) · Journal of Proteome Research · doi:10.1021/pr301017e · Cited by 30

The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease

Han, J., Guo, X., Tan, W., Zhang, F., Liu, J., Wang, W., Xu, P., & Lammi, M. J. (2013) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-14-209 · Cited by 29

Compound 9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury in mice by suppressing MAPK signalling

Kim, S., Baek, K. S., Park, H., Jung, Y. H., & Lee, S. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13414 · Cited by 30

KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons

Hung, C., & Coleman, M. P. (2016) · Traffic · doi:10.1111/tra.12428 · Cited by 30

Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice

Lejkowska, R., Kawa, M. P., Pius‐Sadowska, E., Rogińska, D., Łuczkowska, K., Machaliński, B., & Machalińska, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030777 · Cited by 30

Phosphoproteomic Analyses Reveal Signaling Pathways That Facilitate Lytic Gammaherpesvirus Replication

Stahl, J. A., Chavan, S. S., Sifford, J. M., MacLeod, V., Voth, D. E., Edmondson, R. D., & Forrest, J. C. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003583 · Cited by 28

Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions

Caunt, C. J., & McArdle, C. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.076349 · Cited by 28

Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression

Dwivedi, Y., & Zhang, H. (2015) · Neural Plasticity · doi:10.1155/2016/7383724 · Cited by 32

Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-α and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells

Wu, Q.-C., Tang, X., Dai, Z.-Q., Dai, Y., Xiao, H.-H., & Yao, X. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153146 · Cited by 28

Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment

Busquets, O., Ettcheto, M., Cano, A. C., Manzine, P. R., Sánchez‐López, E., Espinosa-Jiménez, T., Verdaguer, E., Castro-Torres, R. D., Beas‐Zárate, C., Sureda, F. X., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010255 · Cited by 28

Metabolic memory and diabetic nephropathy: Beneficial effects of natural epigenetic modifiers

Kushwaha, K., Sharma, S., & Gupta, J. (2020) · Biochimie · doi:10.1016/j.biochi.2020.01.007 · Cited by 32

Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition

Xiao, X., Liu, P., Li, D., Xia, Z., Wang, P., Zhang, X., Liu, M., Liao, L., Jiao, B., & Ren, R. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00912-3 · Cited by 27

The effect of biodegradable silk fibroin-based scaffolds containing glial cell line-derived neurotrophic factor (GDNF) on the corneal regeneration process

Gavrilova, N. A., Анатольевич, Б. С., Revishchin, A. V., Tishchenko, O. E., Ostrovskiy, D. S., Bobrova, M. M., Safonova, L. A., Efimov, А. Е., Агапова, О. И., Agammedov, M. B., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.06.040 · Cited by 28

INTRACELLULAR SIGNALING BY BILE ACIDS

Anwer, M. (2014) · Journal of Bio-Science · doi:10.3329/jbs.v20i0.17647 · Cited by 28

Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1

Yndestad, A., Marshall, A. K., Hodgkinson, J. D., Tham, E. L., Sugden, P. H., & Clerk, A. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.021 · Cited by 28

Bitter melon (Momordica charantia) extract suppresses cytokineinduced activation of MAPK and NF-κB in pancreatic β-Cells

Kim, K., & Kim, H. Y. (2011) · Food Science and Biotechnology · doi:10.1007/s10068-011-0074-x · Cited by 28

MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty

Bailey, A. N., Hocker, A. D., Vermillion, B. R., Smolkowski, K., Shah, S. N., Jewett, B. A., & Dreyer, H. C. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00146.2012 · Cited by 28

Inhibitory effects of armepavine against hepatic fibrosis in rats

Weng, T., Shen, C., Chiu, Y.-T., Lin, Y., Kuo, C., & Huang, Y. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-78 · Cited by 29

MAP Kinase cross talks in oxidative stress‐induced impairment of insulin secretion. Involvement in the protective activity of quercetin

Youl, E., Magous, R., Cros, G. H., & Oiry, C. (2014) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12078 · Cited by 28

ERK5 regulation in naïve T‐cell activation and survival

Ananieva, O., Macdonald, A., Wang, X., McCoy, C. E., McIlrath, J. M., Tournier, C., & Arthur, J. S. C. (2008) · European Journal of Immunology · doi:10.1002/eji.200737867 · Cited by 28

Oxidative stress and adenosine A1receptor activation differentially modulate subcellular cardiomyocyte MAPKs

Ballard‐Croft, C., Locklar, A. C., Keith, B. J., Mentzer, R. M., & Lasley, R. D. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01067.2007 · Cited by 28

5,7,3′‐trihydroxy‐3,4′‐dimethoxyflavone‐induced cell death in human Leukemia cells is dependent on caspases and activates the MAPK pathway

Torres, F., Quintana, J., & Estévez, F. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20619 · Cited by 28

Effects of pyridine analogs of curcumin on growth, apoptosis and NF-κB activity in prostate cancer PC-3 cells.

Wei, X., Zhou, D., Wang, H., Ding, N., Cui, X., Wang, H., Verano, M., Zhang, K., Conney, A. H., Zheng, X., et al. (2013) · PubMed · Cited by 27

Polysaccharides from Agrocybe cylindracea residue alleviate type 2-diabetes-induced liver and colon injuries by p38 MAPK signaling pathway

Sun, W., Zhang, Y., & Jia, L. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101690 · Cited by 28

Crosstalk between phytochemicals and inflammatory signaling pathways

Prasad, S., Kumar, V., Singh, C., & Singh, A. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01206-z · Cited by 29

The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway

Chen, Y., Chen, H., Cheng, Y., Lin, Y., Liu, K.-W., Chen, Y., Hou, M., Wu, Y., Lee, Y., & Yuan, S. F. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.04.007 · Cited by 27

Roles of P67/MetAP2 as a tumor suppressor

Datta, B. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.002 · Cited by 27

Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells

Gu, M., Raina, K., Agarwal, C., & Agarwal, R. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20560 · Cited by 27

Involvement of MAPK activation and ROS generation in human leukemia U937 cells undergoing apoptosis in response to sonodynamic therapy

Su, X., Wang, P., Wang, X., Guo, L., Li, S., & Liu, Q. (2013) · International Journal of Radiation Biology · doi:10.3109/09553002.2013.817700 · Cited by 27

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations

Preto, A., Gonçalves, J., Rebocho, A. P., Figueiredo, J., Meireles, A. M., Rocha, A. S., Vasconcelos, M. H., Seca, H., Seruca, R., Soares, P., et al. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-387 · Cited by 27

miR‐128 Regulates Genes Associated with Inflammation and Fibrosis of Rat Kidney Cells In Vitro

Shyamasundar, S., Ong, C., Yung, L. L., Dheen, S. T., & Bay, B. (2017) · The Anatomical Record · doi:10.1002/ar.23763 · Cited by 27

GRK2-Dependent Desensitization Downstream of G Proteins

Jurado-Pueyo, M., Campos, P. M., Mayor, F., & Murga, C. (2008) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890801941939 · Cited by 27

Anti-skin aging activity of eggshell membrane administration and its underlying mechanism

Sim, W., Ahn, J., Lim, W., Son, D. J., Lee, E., & Lim, T. (2022) · Molecular & Cellular Toxicology · doi:10.1007/s13273-022-00291-5 · Cited by 30

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases

Hajjo, R., Sabbah, D. A., Abusara, O. H., Kharmah, R., & Bardaweel, S. K. (2023) · Viruses · doi:10.3390/v15020568 · Cited by 28

Pathways involved in acetaminophen hepatotoxicity with specific targets for inhibition/downregulation

Karthivashan, G., Arulselvan, P., & Fakurazi, S. (2015) · RSC Advances · doi:10.1039/c5ra07838e · Cited by 26

G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases

Hu, J., Li, T., Du, X., Wu, Q. E., & Le, Y.-Z. (2017) · Vision Research · doi:10.1016/j.visres.2017.05.001 · Cited by 26

Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood

Horie, T., Fukasawa, K., Yamada, T., Mizuno, S., Iezaki, T., Tokumura, K., Iwahashi, S., Sakai, S., Suzuki, A., Kubo, T., et al. (2022) · Stem Cells · doi:10.1093/stmcls/sxac011 · Cited by 26

Low fucose containing bacterial polysaccharide facilitate mitochondria‐dependent ROS‐induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs‐mediated Nrf2/Keap1 homeostasis signaling

Chowdhury, S. R., Sengupta, S., Biswas, S., Sen, R., Sinha, T. K., Basak, R. K., Adhikari, B., & Bhattacharyya, A. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22236 · Cited by 26

ERK phosphorylation and nuclear accumulation: insights from single-cell imaging

Caunt, C. J., & McArdle, C. A. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110662 · Cited by 26

Activation of the Smk1 Mitogen-Activated Protein Kinase by Developmentally Regulated Autophosphorylation

Whinston, E. R., Omerza, G., Singh, A., Tio, C. W., & Winter, E. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-12 · Cited by 26

ROS and ERK1/2-mediated caspase-9 activation increases XAF1 expression in dexamethasone-induced apoptosis of EBV-transformed B cells

Park, G. B., Choi, Y., Kim, Y. S., Lee, H.-K., Kim, D., & Hur, D. Y. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1949 · Cited by 27

Constitutive MAP Kinase Activation in Hematopoietic Stem Cells Induces a Myeloproliferative Disorder

Chung, E., Hsu, C.-L., & Kondo, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028350 · Cited by 26

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ

Maisonneuve, P., Caillet‐Saguy, C., Vaney, M. C., Bibi-Zainab, E., Sawyer, K. M., Raynal, B. D. E., Haouz, A., Delepierre, M., Lafon, M., Cordier, F., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.707208 · Cited by 26

Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway

Li, C., Chen, Z., Yang, H., Luo, F., Chen, L., Cai, H., Li, Y., You, G., Long, D., Li, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159079 · Cited by 26

Specific Regulation of Cytokine-Dependent p38 MAP Kinase Activation by p62/SQSTM1

Kawai, K., Saito, A., SUDO, T., & Osada, H. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvn027 · Cited by 26

Insulin-Regulated Srebp-1c and Pck1 mRNA Expression in Primary Hepatocytes from Zucker Fatty but Not Lean Rats Is Affected by Feeding Conditions

Zhang, Y., Chen, W., Li, R., Li, Y., Ge, Y., & Chen, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021342 · Cited by 27

Oxidative stress modulates the expression of genes involved in cell survival in ΔF508 cystic fibrosis airway epithelial cells

Voisin, G., Bouvet, G. F., Legendre, P., Dagenais, A., Massé, C., & Berthiaume, Y. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00003.2014 · Cited by 33

A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach

Lee, S., Warthaka, M., Yan, C., Kaoud, T. S., Piserchio, A., Ghose, R., Ren, P., & Dalby, K. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018594 · Cited by 26

Mitogen-activated protein kinase phosphatase-1 – a potential therapeutic target in metabolic disease

Flach, R. J. R., & Bennett, A. M. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.528395 · Cited by 25

A Crucial Role for Gαq/11, But Not Gαi/o or Gαs, in Gonadotropin-Releasing Hormone Receptor-Mediated Cell Growth Inhibition

White, C. D., Coetsee, M., Morgan, K., Flanagan, C. A., Millar, R. P., & Lu, Z.-L. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0122 · Cited by 25

Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules

Mekel, M., Nucera, C., Hodin, R. A., & Parangi, S. (2010) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2009.08.029 · Cited by 25

Effects of low concentration of endosulfan on proliferation, ERK1/2 pathway, apoptosis and senescence in Nile tilapia (Oreochromis niloticus) splenocytes

Téllez‐Bañuelos, M. C., Ortiz‐Lazareno, P. C., Santerre, A., Casas‐Solís, J., Bravo‐Cuéllar, A., & Zaitseva, G. P. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.10.003 · Cited by 25

Phosphorylation of nucleoporins

Kosako, H., & Imamoto, N. (2010) · Nucleus · doi:10.4161/nucl.1.4.11744 · Cited by 25

Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades

Gaestel, M., & Kracht, M. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682299 · Cited by 27

Dequalinium induces human leukemia cell death by affecting the redox balance

Garcia-Perez, A. I., Galeano, E., Nieto, E. O., & Sancho, P. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.03.012 · Cited by 25

Role of Extracellular Signal-regulated Kinase 5 in Adipocyte Signaling

Zhu, H., Guariglia, S. R., Li, W., Brancho, D., Wang, Z. V., Scherer, P. E., & Chow, C.-W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.506584 · Cited by 24

Effect of penehyclidine hydrochloride on expressions of MAPK in mice with CLP-induced acute lung injury

Zhan, J., Liu, Y., Zhang, Z., Chen, C., Chen, K., & Wang, Y. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0310-0 · Cited by 25

PKC-epsilon activation is required for recognition memory in the rat

Zisopoulou, S., Asimaki, O., Leondaritis, G., Vasilaki, A., Sakellaridis, N., Pitsikas, N., & Mangoura, D. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.036 · Cited by 25

A Journey Through Mitogen-Activated Protein Kinase and Ochratoxin A Interactions

Rumora, L., & Grubišić, T. Ž. (2009) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/10004-1254-60-2009-1969 · Cited by 25

Mitogen-Activated Protein Kinase-Activated Kinase RSK2 Plays a Role in Innate Immune Responses to Influenza Virus Infection

Kakugawa, S., Shimojima, M., Goto, H., Horimoto, T., Oshimori, N., Neumann, G., Yamamoto, T. S., & Kawaoka, Y. (2009) · Journal of Virology · doi:10.1128/jvi.02416-08 · Cited by 25

Inhibition of MAPK/ERK, PKC and CaMKII signaling blocks cytolysin-induced human glioma cell death.

Soletti, R. C., Alves, T. R., Vernal, J. I., Terenzi, H. F., Anderluh, G., Borges, H. L., Gabilan, N. H., & Moura‐Neto, V. (2010) · PubMed · Cited by 25

Guanine nucleotide exchange factor Epac2–dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells

Emery, A. C., Xu, W., Eiden, M. V., & Eiden, L. E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.790329 · Cited by 25

Physiological crosstalk between the AC/PKA and PLC/PKC pathways modulates melatonin-mediated, monochromatic-light-induced proliferation of T-lymphocytes in chickens

Guo, Q., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2644-6 · Cited by 25

Selenium-enriched Bacillus paralicheniformis SR14 attenuates H2O2-induced oxidative damage in porcine jejunum epithelial cells via the MAPK pathway

Xiao, X., Cheng, Y., Song, D., Li, X., Hu, Y., Lu, Z., Wang, F., & Wang, Y. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09922-9 · Cited by 25

Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP‐2

Zanotti, S., Smerdel‐Ramoya, A., Stadmeyer, L., & CANALIS, E. M. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21715 · Cited by 25

Hypoxia Regulates the Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Cells Under Cyclic Tensile Stress via Mitogen‐Activated Protein Kinase Pathways

Li, L., Han, M., Li, S., Xu, Y., & Wang, L. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.130048 · Cited by 25

Therapeutic potential of adenosine receptor modulators in cancer treatment

Maity, P., Ganguly, S., & Deb, P. K. (2025) · RSC Advances · doi:10.1039/d5ra02235e · Cited by 26

Benzidine induces epithelial–mesenchymal transition in human uroepithelial cells through ERK1/2 pathway

Zhao, L., Geng, H., Liang, Z., Zhang, Z., Zhang, T., Yu, D., & Zhong, C. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.163 · Cited by 24

MAP Kinase Modules: The Excursion Model and the Steps that Count

Piala, A. T., Humphreys, J. M., & Goldsmith, E. J. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.09.024 · Cited by 22

Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL

Tung, S., Lee, K., Lee, K.-F., Yang, Y., Huang, W., Lee, L., Chen, W.-P., Chen, C., Teng, C., Shen, C., et al. (2021) · Food & Function · doi:10.1039/d0fo03089a · Cited by 25

Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2

Piserchio, A., Ramakrishan, V., Wang, H., Kaoud, T. S., Arshava, B. M., Dutta, K., Dalby, K. N., & Ghose, R. (2015) · Scientific Reports · doi:10.1038/srep11127 · Cited by 27

Modulation of arsenic-induced epidermal growth factor receptor pathway signalling by resveratrol

Herbert, K. J., & Snow, E. T. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.05.004 · Cited by 24

The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5

Gerits, N., Shiryaev, A., Kostenko, S., Klenow, H. B., Shiryaeva, O., Johannessen, M., & Moens, U. L. (2009) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-009-0020-6 · Cited by 24

Amplification of JNK Signaling Is Necessary To Complete the Murine Gammaherpesvirus 68 Lytic Replication Cycle

Stahl, J. A., Paden, C. R., Chavan, S. S., MacLeod, V., Edmondson, R. D., Speck, S. H., & Forrest, J. C. (2012) · Journal of Virology · doi:10.1128/jvi.01432-12 · Cited by 24

Integration of a Phosphatase Cascade with the Mitogen-activated Protein Kinase Pathway Provides for a Novel Signal Processing Function

Chaudhri, V. K., Kumar, D., Misra, M., Dua, R., & Rao, K. V. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.055863 · Cited by 24

Biology using engineering tools

Birtwistle, M. R., & Kölch, W. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16245 · Cited by 27

ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser1270

Baraúna, V. G., Campos, L. C. G., Miyakawa, A. A., & Krieger, J. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022803 · Cited by 24

IMP Modulates KSR1-dependent Multivalent Complex Formation to Specify ERK1/2 Pathway Activation and Response Thresholds

Chen, C., Lewis, R. E., & White, M. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709305200 · Cited by 24

Impact of ERK activation on fly survival and Wolbachia-mediated protection during virus infection

Wong, Z. S., Brownlie, J. C., & Johnson, K. N. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000456 · Cited by 27

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A

Oben, K. Z., Alhakeem, S. S., McKenna, M. K., Brandon, J. A., Mani, R., Noothi, S. K., Liu, J., Akunuru, S., Dhar, S. K., Singh, I. P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20497 · Cited by 24

Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Wei, J., Li, Y., Liu, Q., Lan, Y., Wei, C., Tian, K., Wu, L., Lin, C., Xu, J., Zhao, J., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01025 · Cited by 24

MKK4/SEK1 Is Negatively Regulated through a Feedback Loop Involving the E3 Ubiquitin Ligase Itch

Ahn, Y., & Kurie, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044958 · Cited by 25

Flavonoids isolated from Citrus platymamma induce mitochondrial-dependent apoptosis in AGS cells by modulation of the PI3K/AKT and MAPK pathways

Lee, H. J., Nagappan, A., PARK, H. S., Hong, G. E., Yumnam, S., Raha, S., Saralamma, V. V. G., Lee, W. S., Kim, E. H., & Kim, G. S. (2015) · Oncology Reports · doi:10.3892/or.2015.4122 · Cited by 23

15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3.

Suk, F., Jou, W. J., Lin, R.-J., Lin, S. Y., Tzeng, F. Y., & Liang, Y.-C. (2013) · PubMed · Cited by 23

Diabetic Neuropathy: Review on Molecular Mechanisms

Sanaye, M., & Kavishwar, S. A. (2021) · Current Molecular Medicine · doi:10.2174/1566524021666210816093111 · Cited by 24

The MAPK Signaling Cascades

Maik-Rachline, G., Wexler, S., & Seger, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00130-9 · Cited by 2

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600

MAP Kinase PathwaysPreprint

Morrison, D. K. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011254 · Cited by 846

Mitogen‐activated Protein Kinases ( MAPKs ): ERKs , JNKs , and p 38 s

Chen, W., Juang, Y.-C. A., & Cobb, M. H. (2008) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb348

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274