Differential regulation and properties of MAPKs

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,400

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266

Protein Tyrosine Phosphatases in the Human Genome

Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T. (2004) · Cell · doi:10.1016/j.cell.2004.05.018 · Cited by 1,886

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886

Signal Transduction through MAP Kinase Cascades

Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759

Anterior pituitary adenomas: inherited syndromes, novel genes and molecular pathways

Xekouki, P., Azevedo, M. F., & Stratakis, C. A. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.47 · Cited by 47

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway

Lagares‐Tena, L., García-Monclús, S., López‐Alemany, R., Almacellas‐Rabaiget, O., Huertas-Martínez, J., Sáinz‐Jaspeado, M., Mateo‐Lozano, S., Galindo, C. R., Rello‐Varona, S., Herrero‐Martín, D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10872 · Cited by 50

JNK Inhibitor SP600125 Attenuates Paraquat-Induced Acute Lung Injury: an In Vivo and In Vitro Study

Shen, H., Wu, N., Wang, Y., Han, X., Zheng, Q., Cai, X., Zhang, H., & Zhao, M. (2017) · Inflammation · doi:10.1007/s10753-017-0575-8 · Cited by 46

Spirulina Extract Enhanced a Protective Effect in Type 1 Diabetes by Anti-Apoptosis and Anti-ROS Production

Lee, J., Park, A., Kim, M. K., Lim, H., Rha, Y., & Kang, H. (2017) · Nutrients · doi:10.3390/nu9121363 · Cited by 46

How Mitogen-Activated Protein Kinases Recognize and Phosphorylate Their Targets: A QM/MM Study

Turjanski, A. G., Hummer, G., & Gutkind, J. S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8071995 · Cited by 46

Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors

Geest, C. R., Buitenhuis, M., Koerkamp, M. J. A. G., Holstege, F. C. P., Vellenga, E., & Coffer, P. J. (2009) · Blood · doi:10.1182/blood-2008-08-175141 · Cited by 47

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling

Shen, Q., Han, Y., Wu, K., He, Y., Jiang, X., Liu, P., Xia, C., Xiong, Q., Liu, R. R., Chen, Q., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00945-9 · Cited by 45

Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice

Lee, S.-Y., Stadanlick, J. E., Kappes, D. J., & Wiest, D. L. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.04.008 · Cited by 48

Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammation and apoptosis in porcine peripheral blood mononuclear cells in vitro

Bai, F., Ni, B., Liu, M., ZhiXin, F., Xiong, Q., & Shao, G. (2014) · Veterinary Microbiology · doi:10.1016/j.vetmic.2014.11.013 · Cited by 45

Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases

Giordano, G., Klintworth, H. M., Kavanagh, T. J., & Costa, L. G. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.11.004 · Cited by 45

SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway

Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F., Yang, J., Liu, B., Xiang, G., & Chen, Q. (2017) · Oncology Reports · doi:10.3892/or.2017.5982 · Cited by 44

Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity

Wu, J.-Y., Xiang, S., Zhang, M., Fang, B., Huang, H., Kwon, O. K., Zhao, Y., Yang, Z., Bai, W., Bepler, G., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.795955 · Cited by 46

Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway

Chen, C., Chen, Y., Hsieh, Y., Weng, C., Yeh, J., Yang, S., Lin, C., & Yang, J. (2018) · Environmental Toxicology · doi:10.1002/tox.22555 · Cited by 45

The Biology of the Nuclear Envelope and Its Implications in Cancer Biology

Alvarado-Kristensson, M., & Rosselló, C. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102586 · Cited by 46

Integration of Protein Kinases mTOR and Extracellular Signal-Regulated Kinase 5 in Regulating Nucleocytoplasmic Localization of NFATc4

Yang, T. T. C., Yu, R. Y.-L., Agadir, A., Gao, G., Campos‐González, R., Tournier, C., & Chow, C.-W. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01847-07 · Cited by 46

Cholecystokinin (CCK) Regulation of Pancreatic Acinar Cells: Physiological Actions and Signal Transduction Mechanisms

Williams, J. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180014 · Cited by 54

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

Miyatake, K., Kusakabe, M., Takahashi, C., & Nishida, E. (2015) · Nature Communications · doi:10.1038/ncomms7666 · Cited by 43

LncRNA‐MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis ‐modulation of MAP3K4

Zhou, H., Simion, V., Pierce, J. B., Haemmig, S., Chen, A. F., & Feinberg, M. W. (2020) · The FASEB Journal · doi:10.1096/fj.202001654rr · Cited by 44

Stress kinases in the development of liver steatosis and hepatocellular carcinoma

Cicuéndez, B., Ruiz-Garrido, I., Mora, A., & Sabio, G. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101190 · Cited by 45

Structure–activity relationship (SAR) studies of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione: Development of potential substrate-specific ERK1/2 inhibitors

Li, Q., Al‐Ayoubi, A. M., Guo, T.-L., Zheng, H., Sarkar, A., Nguyen, T., Eblen, S. T., Grant, S., Kellogg, G. E., & Zhang, S. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.09.057 · Cited by 44

Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss

Sharma, A. R., Lee, Y., Bat-Ulzii, A., Chatterjee, S., Bhattacharya, M., Chakraborty, C., & Lee, S. (2023) · Nutrients · doi:10.3390/nu15040919 · Cited by 49

Advances of the MAPK pathway in the treatment of spinal cord injury

Huang, S., Zhang, Y., Shu, H., Liu, W., Zhou, X., & Zhou, X. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14807 · Cited by 46

Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

Åberg, E., Torgersen, K. M., Johansen, B., Keyse, S. M., Perander, M., & Seternes, O. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023283 · Cited by 43

VHR / DUSP 3 phosphatase: structure, function and regulation

Pavic, K., Duan, G., & Köhn, M. (2015) · FEBS Journal · doi:10.1111/febs.13263 · Cited by 46

BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors

Tsuchida, R., Osawa, T., Wang, F., Nishii, R., Das, B., Tsuchida, S., Muramatsu, M., Takahashi, T., Inoue, T., Wada, Y., et al. (2013) · Oncogene · doi:10.1038/onc.2013.358 · Cited by 44

MAPK Phosphatase-1 (MKP-1) Expression Is Up-Regulated by hCG/cAMP and Modulates Steroidogenesis in MA-10 Leydig Cells

Brion, L., Maloberti, P. M., Gomez, N. V., Poderoso, C., Gorostizaga, A., Garcia, M. M. M. S., Acquier, A. B., Cooke, M., Méndez, C. F., Podesta, E. J., et al. (2011) · Endocrinology · doi:10.1210/en.2011-0021 · Cited by 45

TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways

Shen, W., Du, R., Li, J., Luo, X., Zhao, S., Chang, A., Zhou, W., Gao, R., Luo, D., Wang, J., et al. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2016.13 · Cited by 43

Cypermethrin Promotes Lung Cancer Metastasis via Modulation of Macrophage Polarization by Targeting MicroRNA-155/Bcl6

Huang, F., Chen, Z., Chen, H., Lu, W., Xie, S., Meng, Q. H., Wu, Y., & Xia, D. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy039 · Cited by 43

PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum

Hitz, E., Balestra, A. C., Brochet, M., & Voss, T. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-68717-5 · Cited by 43

Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the Yeast Cell Integrity Pathway

Jiménez-Sánchez, M., Cid, V. J., & Molina, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706270200 · Cited by 43

Inhibition of EGF‐induced ERK/MAP kinase‐mediated astrocyte proliferation by μ opioids: integration of G protein and β‐arrestin 2‐dependent pathways

Miyatake, M., Rubinstein, T. J., McLennan, G., Belcheva, M. M., & Coscia, C. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06156.x · Cited by 43

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

Zhang, Y., Opresko, L. K., Shankaran, H., Chrisler, W., Wiley, H. S., & Resat, H. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-78 · Cited by 42

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

Wang, Z., Guo, Q., Wang, R., Xu, G., Li, P., Sun, Y., She, X., Liu, Q., Chen, Q., Yu, Z., et al. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0355-1 · Cited by 42

Crosstalks between Raf-kinase inhibitor protein and cancer stem cell transcription factors (Oct4, KLF4, Sox2, Nanog)

Lee, S., Wottrich, S., & Bonavida, B. (2017) · Tumor Biology · doi:10.1177/1010428317692253 · Cited by 42

Fibroblast growth factor-2 stimulates proliferation of human adipose-derived stem cells via Src activation

Ma, Y., Kakudo, N., Morimoto, N., Lai, F., Taketani, S., & Kusumoto, K. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1462-z · Cited by 42

Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development

Urness, L. D., Li, Z., Wang, X., & Mansour, S. L. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21380 · Cited by 44

The Role of RIP2 in p38 MAPK Activation in the Stressed Heart

Jacquet, S., Nishino, Y., Kumphune, S., Sicard, P., Clark, J., Kobayashi, K. S., Flavell, R. A., Eickhoff, J., Cotten, M. L., & Marber, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707750200 · Cited by 42

The Extracellular Signal-regulated Kinase–Mitogen-activated Protein Kinase Pathway Phosphorylates and Targets Cdc25A for SCF β-TrCP -dependent Degradation for Cell Cycle Arrest

Isoda, M., Kanemori, Y., Nakajo, N., Uchida, S., Yamashita, K., Ueno, H., & Sagata, N. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0008 · Cited by 42

Activation of the JNK pathway by nanosecond pulsed electric fields

Morotomi‐Yano, K., Uemura, Y., Katsuki, S., Akiyama, H., & Yano, K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.056 · Cited by 42

Crystal structure of ERK2 G169D mutant

Yin, J., Jaiswal, B. S., & Wang, W. (2018) · Worldwide Protein Data Bank · doi:10.2210/pdb6d5y/pdb · Cited by 42

Structural characterization of the cyclin-dependent protein kinase family

Endicott, J., & Noble, M. E. M. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130097 · Cited by 40

A ERK/RSK‐mediated negative feedback loop regulates M‐CSF–evoked PI3K/AKT activation in macrophages

Wang, L., Iorio, C., Yan, K., Yang, H. H., Takeshita, S., Kang, S., Neel, B. G., & Yang, W. (2017) · The FASEB Journal · doi:10.1096/fj.201700672rr · Cited by 42

An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest

Zhang, B., Zhu, L., Dai, Y., Li, H., Huang, K., Luo, Y., & Xu, W. (2019) · Epigenetics · doi:10.1080/15592294.2019.1644878 · Cited by 41

Brain JNK and metabolic disease

Nogueiras, R., & Sabio, G. (2020) · Diabetologia · doi:10.1007/s00125-020-05327-w · Cited by 42

The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway

Sato, T. Z., Takahashi, H., Hatakeyama, S., Iguchi, A., & Ariga, T. (2014) · Oncogene · doi:10.1038/onc.2014.68 · Cited by 41

Cardioprotection induced by Na+/K+-ATPase activation involves extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase/Akt pathway

Zheng, J.-H., Koh, X., Hua, F., Li, G., Larrick, J. W., & Bian, J. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq263 · Cited by 40

Stimulated nuclear import by β-like importins

Flores, K., & Seger, R. (2013) · F1000Prime Reports · doi:10.12703/p5-41 · Cited by 40

Eupatorin-Induced Cell Death in Human Leukemia Cells Is Dependent on Caspases and Activates the Mitogen-Activated Protein Kinase Pathway

Estévez, S., Marrero, M. T., Quintana, J., & Estévez, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112536 · Cited by 40

Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras–MKK3–p38 to regulate in vitro cellular invasion

Behren, A., Mühlen, S., Sanhueza, G. A., Schwager, C., Plinkert, P. K., Huber, P. E., Abdollahi, A., & Simon, C. (2009) · Oncogene · doi:10.1038/onc.2009.436 · Cited by 40

Palytoxin and an Ostreopsis Toxin Extract Increase the Levels of mRNAs Encoding Inflammation-Related Proteins in Human Macrophages via p38 MAPK and NF-κB

Crinelli, R., Carloni, E., Giacomini, E., Penna, A., Dominici, S., Battocchi, C., Ciminiello, P., Dell’Aversano, C., Fattorusso, E., Forino, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038139 · Cited by 40

Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf

Samadani, R., Zhang, J., Brophy, A., Oashi, T., Priyakumar, U. D., Raman, E. P., John, F. J. S., Jung, K.-Y., Fletcher, S., Pozharski, E. V., et al. (2015) · Biochemical Journal · doi:10.1042/bj20131571 · Cited by 40

Expression and analyses of the HIF-1 pathway in the lungs of humans with pulmonary arterial hypertension

Lei, W., He, Y. Z., Shui, X., Li, G., Yan, G., Zhang, Y., Huang, S., Chen, C., & Ding, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5752 · Cited by 40

Application of vitamin D and vitamin D analogs in acute myelogenous leukemia

Cao, H. L., Xu, Y., de Necochea-Campion, R., Baylink, D. J., Payne, K. J., Tang, X., Ratanatharathorn, C., Ji, Y., Mirshahidi, S., & Chen, C.-S. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.01.007 · Cited by 41

Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation

Qiang, L., Wang, J., Zhang, Y., Ge, P., Chai, Q., Li, B., Shi, Y., Zhang, L., Gao, G. F., & Liu, C. H. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0016-0 · Cited by 40

Regulation of human mitogen‐activated protein kinase 15 (extracellular signal‐regulated kinase 7/8) and its functions: A recent update

Lau, A. T. Y., & Xu, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27053 · Cited by 40

The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal neurotoxicity in Sprague Dawley rats

Li, J., Li, X., Bi, H., & Li, B. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.12.038 · Cited by 40

Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells

Mohan, C. D., Liew, Y. Y., Jung, Y. Y., Rangappa, S., Preetham, H. D., Chinnathambi, A., Alahmadi, T. A., Alharbi, S. A., Lin, Z., Rangappa, K. S., et al. (2021) · Biochimie · doi:10.1016/j.biochi.2021.01.009 · Cited by 40

Role of ERK1/2 signaling in dengue virus-induced liver injury

Sreekanth, G. P., Chuncharunee, A., Sirimontaporn, A., Panaampon, J., Srisawat, C., Morchang, A., Malakar, S., Thuwajit, P., Kooptiwut, S., Suttitheptumrong, A., et al. (2014) · Virus Research · doi:10.1016/j.virusres.2014.03.025 · Cited by 40

Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways

Yang, X., Liu, S., Liu, Y., Liu, J., Liu, T., Wang, X., & Yan, Q. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22250 · Cited by 40

Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line

Buzzi, N. S., Bilbao, P., Boland, R., & de Boland, A. R. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.10.005 · Cited by 40

Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumors

Mauriz, J. L., Martín‐Renedo, J., Palomo, A. G., Tuñón, M. J., & González‐Gallego, J. (2010) · Current Drug Targets · doi:10.2174/1389450111009011439 · Cited by 40

BRAF Mutation Testing in Colorectal Cancer

Sharma, S. G., & Gulley, M. L. (2010) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2009-0232-rs.1 · Cited by 38

Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549

Chen, H.-M., Lee, M.-J., Kuo, C., Tsai, P. L., Liu, J.-Y., & Kao, S.-H. (2010) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2011/739093 · Cited by 48

Inhibitory effects of hydrogen sulphide on pulmonary fibrosis in smoking rats via attenuation of oxidative stress and inflammation

Zhou, X., An, G., & Chen, J. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12254 · Cited by 39

HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGFβ2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells

Cui, X., Qin, C., Zhang, Z., Su, Z., Liu, X., Wang, S.-K., & Tian, X. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3033-6 · Cited by 39

Regulation of Spontaneous Eosinophil Apoptosis—A Neglected Area of Importance

Ilmarinen, P., Moilanen, E., & Kankaanranta, H. (2014) · Journal of Cell Death · doi:10.4137/jcd.s13588 · Cited by 39

BMK1 is involved in the regulation of p53 through disrupting the PML–MDM2 interaction

Yang, Q., Liao, L., Deng, X., Chen, R., Gray, N. S., Yates, J. R., & Lee, J. D. (2012) · Oncogene · doi:10.1038/onc.2012.332 · Cited by 39

Noncanonical Mode of ERK Action Controls Alternative αβ and γδ T Cell Lineage Fates

Lee, S.-Y., Coffey, F. J., Fahl, S. P., Peri, S., Rhodes, M. R., Cai, K. Q., Carleton, M. O., Hedrick, S. Μ., Fehling, H. J., Zúñiga‐Pflücker, J. C., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.021 · Cited by 41

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

Min, X., Akella, R., He, H., Humphreys, J. M., Tsutakawa, S. E., Lee, S., Tainer, J. A., Cobb, M. H., & Goldsmith, E. J. (2009) · Structure · doi:10.1016/j.str.2008.11.007 · Cited by 39

Regulation of BRAF protein stability by a negative feedback loop involving the MEK–ERK pathway but not the FBXW7 tumour suppressor

Aguilar-Hernández, M., PATEL, B., Hey, F., Giblett, S. M., Belnoue-Davis, H. L., & Pritchard, C. A. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.02.009 · Cited by 34

Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Schaefer, T. L., Davenport, M. H., Grainger, L. M., Robinson, C. K., Earnheart, A. T., Stegman, M., Lang, A. L., Ashworth, A. A., Molinaro, G., Huber, K. M., et al. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9184-y · Cited by 38

The protective effect of coptisine on experimental atherosclerosis ApoE−/− mice is mediated by MAPK/NF-κB-dependent pathway

Feng, M., Kong, S., Zhen-xu, W., He, K., Zou, Z., Hu, Y., Ma, H., Li, X., & Ye, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.002 · Cited by 39

Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition

Xun, Y., Zhou, P., Yang, Y., Li, C., Zhang, J., Hu, H., Qin, B., Zhang, Z., Wang, Q., Lu, Y., et al. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8159 · Cited by 39

5-aminolevulinic acid induce apoptosis via NF-κB/JNK pathway in human oral cancer Ca9-22 cells

Chen, H., Liu, C.-M., Yang, H., Chou, H., Chiang, C., & Kuo, M. Y. (2010) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2010.00973.x · Cited by 39

Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons

Ramiro‐Cortés, Y., Guemez‐Gamboa, A., & Morán, J. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.06.001 · Cited by 39

Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex

Alexa, A., Gógl, G., Glatz, G., Garai, Á., Zeke, A., Varga, J. M., Dudás, E. F., Jeszenői, N., Bodor, A., Hetényi, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417571112 · Cited by 42

Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARα

Rakkestad, K. E., Holme, J. A., Paulsen, R. E., Schwarze, P. E., & Becher, R. (2009) · Inhalation Toxicology · doi:10.3109/08958370903019885 · Cited by 41

Hydrogen sulfide improves left ventricular function in smoking rats via regulation of apoptosis and autophagy

Zhou, X., An, G., & Chen, J. (2014) · APOPTOSIS · doi:10.1007/s10495-014-0978-z · Cited by 38

TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer

Shen, W., Chang, A., Wang, J., Zhou, W., Gao, R., Li, J., Xu, Y., Luo, X., Xiang, R., Luo, N., et al. (2015) · Oncogenesis · doi:10.1038/oncsis.2015.30 · Cited by 39

High glucose and high insulin conditions promote MCF-7 cell proliferation and invasion by upregulating IRS1 and activating the Ras/Raf/ERK pathway

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Anti-tumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways

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