The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy
Abstract
Among other nanoparticle systems, gold nanoparticles have been explored as radiosensitizers. While most of the research in this area has focused on either gold nanoparticles with diameters of less than 2 nm or particles with micrometer dimensions, it has been shown that nanoparticles 50 nm in diameter have the highest cellular uptake. We present the results of in vitro studies that focus on the radiosensitization properties of nanoparticles in the size range from 14-74 nm. Radiosensitization was dependent on the number of gold nanoparticles internalized within the cells. Gold nanoparticles 50-nm in diameter showed the highest radiosensitization enhancement factor (REF) (1.43 at 220 kVp) compared to gold nanoparticles of 14 and 74 nm (1.20 and 1.26, respectively). Using 50-nm gold nanoparticles, the REF for lower- (105 kVp) and higher- (6 MVp) energy photons was 1.66 and 1.17, respectively. DNA double-strand breaks were quantified using radiation-induced foci of gamma-H2AX and 53BP1, and a modest increase in the number of foci per nucleus was observed in irradiated cell populations with internalized gold nanoparticles. The outcome of this research will enable the optimization of gold nanoparticle-based sensitizers for use in therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
DNA repair pathways as targets for cancer therapy
Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666
Hypoxia, DNA repair and genetic instability
Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140
Self-citation
Cited by
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Self-citationPhysical basis and biological mechanisms of gold nanoparticle radiosensitization
Butterworth, K. T., McMahon, S. J., Currell, F. J., & Prise, K. M. (2012) · Nanoscale · doi:10.1039/c2nr31227a · Cited by 478
Wang, S., Li, X., Chen, Y., Cai, X., Yao, H., Gao, W., Zheng, Y., An, X., Shi, J., & Chen, H. (2015) · Advanced Materials · doi:10.1002/adma.201500870 · Cited by 438
Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles
McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., et al. (2011) · Scientific Reports · doi:10.1038/srep00018 · Cited by 429
Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy
Chen, Y., Yang, J., Fu, S., & Wu, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272902 · Cited by 319
Metadata
- Authors
- Chithrani, D. B., Jelveh, S., Jalali, F., van Prooijen, M., Allen, C., Bristow, R. G., Hill, R. P., & Jaffray, D. A.
- Venue
- Radiation Research
- Publisher
- Radiation Research Society
- Published
- 2010-02-26
- Volume
- 173
- Issue
- 6
- Pages
- 719
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W2109840939
- Cited by
- 669
- References
- 4
- FWCI
- 24.35
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy. https://app.cochat.ai/papers/10.1667/rr1984.1
- The paper
- Chithrani, D. B., Jelveh, S., Jalali, F., van Prooijen, M., Allen, C., Bristow, R. G., Hill, R. P., & Jaffray, D. A. (2010). Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy. Radiation Research. https://doi.org/10.1667/rr1984.1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
