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Cited by 273

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

Open access
Falzarano, Darryl, de Wit, Emmie, Martellaro, Cynthia, Callison, Julie, Munster, Vincent J., Feldmann, Heinz·2013·Scientific Reports
DOI 10.1038/srep01686
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Abstract

The identification of a novel β coronavirus, nCoV, as the causative agent of severe respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised concerns about the possibility of a coronavirus pandemic similar to that of SARS-CoV. As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics to address future cases of nCoV. To determine an intervention strategy, the effect of interferon-α2b and ribavirin on nCoV isolate hCoV-EMC/2012 replication in Vero and LLC-MK2 cells was evaluated. hCoV-EMC/2012 was sensitive to both interferon-α2b and ribavirin alone in Vero and LLC-MK2 cells, but only at relatively high concentrations; however, when combined, lower concentrations of interferon-α2b and ribavirin achieved comparable endpoints. Thus, a combination of interferon-α2b and ribavirin, which are already commonly used in the clinic, may be useful for patient management in the event of future nCoV infections.

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Crossref · 10.1038/srep01686

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Metadata

Authors
Falzarano, D., de Wit, E., Martellaro, C., Callison, J., Munster, V. J., & Feldmann, H.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2013-04-18
Volume
3
Issue
1
Pages
1686-1686
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep01686
OpenAlex
W2005094081
Cited by
273
References
39
FWCI
20.19
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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