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Apolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis
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“APOE4 has a strong odds ratio (OR) in non-Hispanic Europeans (OR=14.9), whereas APOE4 risk varies substantially across populations (African Americans and Caribbean Hispanics, OR=2.2–5.7 and East Asians, OR=11.8–33.1)(Liu et al., 2014; Tang et al., 1998).”
From Cholesterol and matrisome pathways dysregulated in astrocytes and microglia (2022) · cites this paper as Liu et al., 2014
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“Africans exhibit lower APOE4-associated AD risk while East Asians show higher APOE4 risk than Europeans (Liu et al., 2014; Tang et al., 1998).”
From Cholesterol and matrisome pathways dysregulated in astrocytes and microglia (2022) · cites this paper as Liu et al., 2014
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Cites
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078
The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., et al. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38094-9 · Cited by 436
Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β
Koffie, R. M., Hashimoto, T., Tai, H.-C., Kay, K. R., Serrano-Pozo, A., Joyner, D., Hou, S., Kopeikina, K. J., Frosch, M. P., Lee, V. M., et al. (2012) · Brain · doi:10.1093/brain/aws127 · Cited by 327
Sando, S. B., Melquist, S., Cannon, A., Hutton, M. L., Sletvold, O., Saltvedt, I., White, L. R., Lydersen, S., & Aasly, J. O. (2008) · BMC Neurology · doi:10.1186/1471-2377-8-9 · Cited by 261
APOE ε2 is associated with intact cognition but increased Alzheimer pathology in the oldest old
Berlau, D. J., Corrada, M. M., Head, E., & Kawas, C. H. (2009) · Neurology · doi:10.1212/01.wnl.0000343853.00346.a4 · Cited by 185
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
Kim, J., Eltorai, A. E. M., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M., & Holtzman, D. M. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20121274 · Cited by 160
Gender and age modify the association between APOE and AD-related neuropathology
Ghebremedhin, E., Schultz, C., Thal, D. R., Rüb, U., Ohm, T. G., Braak, E., & Braak, H. (2001) · Neurology · doi:10.1212/wnl.56.12.1696 · Cited by 108
Flagged first, then by citations
Research works printed but not linked: 47
- Selkoe, D. J. Alzheimer's disease: genes, proteins and therapy. Physiol Rev 81, 741–766 (2001). · DOI · Paper page
- Thies, W. & Bleiler, L. 2011 Alzheimer's disease facts and figures. Alzheimers Dement 7, 208–244 (2011). · DOI
- Siest, G. et al. Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem 41, 1068–1086 (1995). · DOI · Paper page
- Levy-Lahad, E. & Bird, T. D. Genetic factors in Alzheimer's disease: a review of recent advances. Ann Neurol 40, 829–840 (1996). · DOI
- Mahley, R. W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622–630 (1988). · DOI · Paper page
- Mahley, R. W. & Rall, S. C., Jr Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 1, 507–537 (2000). · DOI · Paper page
- Morrow, J. A. et al. Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. Biochemistry 39, 11657–11666 (2000). · DOI · Paper page
- Hauser, P. S. & Ryan, R. O. Impact of apolipoprotein E on Alzheimer's disease. Curr Alzheimer Res 10, 809–817 (2013). · DOI
- Millar, K., Nicoll, J. A., Thornhill, S., Murray, G. D. & Teasdale, G. M. Long term neuropsychological outcome after head injury: relation to APOE genotype. J Neurol Neurosurg Psychiatry 74, 1047–1052 (2003). · DOI
- Lahoz, C. et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 154, 529–537 (2001). · DOI
- Verghese, P. B. et al. ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions. Proc Natl Acad Sci U S A 110, E1807–1816 (2013). · DOI · Paper page
- Claxton, A. et al. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. J Alzheimers Dis 35, 789–797 (2013). · DOI · Paper page
- Chen, D., Zhang, J. & Zhang, Z. Apolipoprotein E Gene Polymorphisms and Alzheimer's Disease. J G Genomics 30, 1167–1170 (2003).
- Zhang, Y., Liu, Z. & Du, Y. Association between Apolipoprotein E gene polymorphism and Vascular dementia and Alzheimer's disease. Shandong Med J 22, 1–2 (2004).
- Mai, Y., Luo, Y., Gu, H., Zhang, L. & LIN, J. Association between Interleukin-8 and Apolipoprotein E gene polymorphism and late-onset Alzheimer's disease. J sun yat-sen uni 1, 118–121 (2010).
- Jia, J., Zhang, J., Xu, M. & Zhou, W. Association between the apolipoprotein E gene polymorphism and the genetic sensitivity of sporadic Alzheimer's disease. Chin J Geriatrics 4, 7–9 (2002).
- Zhu, J., Xu, W. & Gao, Y. The association of apolipoprotein E and Alzheimer's disease. Practical Geriatrics 1, 23–25 (2000).
- Jiang, W., Lv, Z. & Tan, L. Correlation between apolipoprotein E gene polymorphism s and Alzheimer's disease and vascular dementia. J Clin Neurology 6, 408–410 (2010).
- He, S. R., Liu, D. G., Wang, S. & Xia, Y. J. Expression of apolipoprotein E in Alzheimer's disease and its significance. Chin J Pathology 34, 556–560 (2005).
- Zhou, C., Xu, J. & He, J. Genetic correlation study between apolipoprotein E gene and Alzheimer's disease. Med J NDFNC 4, 244–246 (2003).
- Huang, S., Lu, Y. & Chen, S. Inquiring relation between Apolipoprotein E Gene polymorphysm and the Alzheimer's disease. J M Clin Med Bio 1, 9–11 (2001).
- Li, G., Zhao, M., Zuo, L., Liu, F. & Kuang, S. Polymorphism in the Apolipoprotein E Gene and Its Association with Sporadic Alzheimer Disease. J Guiyang Med 1, 24–26 (2006).
- Bi, S. et al. The Relationship between ApoE Genotype, Serum Total Cholesterol Level and Alzheimer's disease. Chin J neuroimmunology 1, 13–16 (2002).
- Wu, P., Guo, Q., Chen, M., Zhou, Y. & Hong, Z. Relationship Between Apolipoprotein E Gene Polymorphism and Early-onset Alzheimer' s Disease. Chin J Clin Neurosci 3, 1168–1170 (2009).
- Zhou, C., Cheng, X. & Xia, X. Relationship between Apolipoprotein E Polymorphism and Alzheimer's Disease in Chongqing. J Chin GP 27, 3115–3117 (2012).
- Yang, J., Yu, F. & Wang, Y. Study of the polymorphisms of APOE gene in Alzheimer's disease and vascular dementia. Neuro Dis Mental H 2, 138–140 (2008).
- Dong, X. The study of the relationship between AD and the ApoE polymorphism. Chin H Care Nutrition 2, 523–524 (2013).
- Yang, L. Study on the association between Apolipoprotein E gene polymorphisms and sporadic Alzheimer's disease. Chin Mod Doctor 24, 89–90 (2008).
- Duan, G., Guo, L. & Yang, L. Study on the Association of Apolipoprotein E-gene Polymorphism with Demented Patients. J Henan Med C 6, 559–561 (2009).
- Lv, X. & Zhong, Y. Study on the relationship between apolipoprotein E gene polymorphism and mild cognitive impairment and Alzheimer's disease. Chin J Gerontology 5, 917–919 (2012).
- Huang, H. M., Kuo, Y. M., Ou, H. C., Lin, C. C. & Chuo, L. J. Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population. J Neural Transm 109, 1415–1421 (2002). · DOI
- Wang, H. K. et al. Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia. J Neural Transm 113, 1499–1509 (2006). · DOI
- Saunders, A. M. et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467–1472 (1993). · DOI · Paper page
- Schmechel, D. E. et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci U S A 90, 9649–9653 (1993). · DOI · Paper page
- Strittmatter, W. J. et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 90, 1977–1981 (1993). · DOI · Paper page
- Rhinn, H. et al. Integrative genomics identifies APOE epsilon4 effectors in Alzheimer's disease. Nature 500, 45–50 (2013). · DOI
- Genin, E. et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 16, 903–907 (2011). · DOI · Paper page
- Ward, A. et al. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology 38, 1–17 (2012). · DOI · Paper page
- Hostage, C. A., Roy Choudhury, K., Doraiswamy, P. M., Petrella, J. R. & Alzheimer's Disease Neuroimaging, I. Dissecting the gene dose-effects of the APOE epsilon4 and epsilon2 alleles on hippocampal volumes in aging and Alzheimer's disease. PLoS One 8, e54483 (2013). · DOI
- Pomara, N. & Bruno, D. Potential effects of the APOE epsilon2 allele and of family history of Alzheimer's disease on brain amyloid-beta in normal elderly. Proc Natl Acad Sci U S A 108, E1007; author reply E1008 (2011). · DOI
- Jofre-Monseny, L., Minihane, A. M. & Rimbach, G. Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 52, 131–145 (2008). · DOI
- Smith, J. D. Apolipoproteins and aging: emerging mechanisms. Ageing Res Rev 1, 345–365 (2002). · DOI
- Jack, C. R., Jr et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 132, 1355–1365 (2009). · DOI · Paper page
- McKhann, G. et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939–944 (1984). · DOI · Paper page
- Kim, S. M. et al. Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele. Neuroradiology 55, 25–34 (2013). · DOI
- DerSimonian, R. & Laird, N. Meta-analysis in clinical trials. Control Clin Trials 7, 177–188 (1986). · DOI · Paper page
- Mantel, N. & Haenszel, W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22, 719–748 (1959).
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
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Hersi, M., Irvine, B., Gupta, P., Gomes, J., Birkett, N., & Krewski, D. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.03.006 · Cited by 332
APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
Belloy, M. E., Andrews, S. J., Le Guen, Y., Cuccaro, M., Farrer, L. A., Napolioni, V., & Greicius, M. D. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.3599 · Cited by 320
Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
Rajabli, F., Feliciano, B. E., Celis, K., Hamilton-Nelson, K. L., Whitehead, P. L., Adams, L. D., Bussies, P. L., Manrique, C. P., Rodriguez, A., Rodriguez, V., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007791 · Cited by 206
Genetics of Alzheimer’s disease: An East Asian perspective
Miyashita, A., Kikuchi, M., Hara, N., & Ikeuchi, T. (2023) · Journal of Human Genetics · doi:10.1038/s10038-022-01050-z · Cited by 64
Metadata
- Authors
- Liu, M., Bian, C., Zhang, J., & Wen, F.
- Venue
- Scientific Reports
- Published
- 2014-03-17
- Volume
- 4
- Issue
- 1
- ISSN
- 2045-2322
- PMC
- PMC3955907
- Cited by
- 72
- References
- 11
- Language
- en
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