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Cited by 521

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study

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Day, Felix R, Elks, Cathy E, Murray, Anna, Ong, Ken K, Perry, John R.B.·2015·Scientific Reports
DOI 10.1038/srep11208
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Abstract

Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and cardiovascular disease in women and therefore represents a potential target for early preventive interventions. We characterised the range of diseases and other adverse health outcomes associated with early or late puberty timing in men and women in the very large UK Biobank study. Recalled puberty timing and past/current diseases were self-reported by questionnaire. We limited analyses to individuals of White ethnicity (250,037 women; 197,714 men) and to disease outcomes with at least 500 cases (~0·2% prevalence) and we applied stringent correction for multiple testing (corrected threshold P < 7.48 × 10–5). In models adjusted for socioeconomic position and adiposity/body composition variables, both in women and men separately, earlier puberty timing was associated with higher risks for angina, hypertension and T2D. Furthermore, compared to the median/average group, earlier or later puberty timing in women or men was associated with higher risks for 48 adverse outcomes, across a range of cancers, cardio-metabolic, gynaecological/obstetric, gastrointestinal, musculoskeletal and neuro-cognitive categories. Notably, both early and late menarche were associated with higher risks for early natural menopause in women. Puberty timing in both men and women appears to have a profound impact on later health.

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Show all 7 references

Research works printed but not linked: 21

  1. Sorensen, K. et al. Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Hormone research in paediatrics 77, 137–145, doi:10.1159/000336325 (2012). · DOI · Paper page
  2. Harrington, J. & Palmert, M. R. Clinical review: Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. The Journal of clinical endocrinology and metabolism 97, 3056–3067, doi:10.1210/jc.2012-1598 (2012). · DOI · Paper page
  3. Prentice, P. & Viner, R. M. Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis. International journal of obesity 37, 1036–1043, doi:10.1038/ijo.2012.177 (2013). · DOI · Paper page
  4. Bodicoat, D. H. et al. Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study. Breast Cancer Res 16, R18, doi:10.1186/bcr3613 (2014). · DOI
  5. Charalampopoulos, D., McLoughlin, A. M., Elks, C. E. & Ong, K. K. Age at menarche and risks of all-cause and cardiovascular mortality: a systematic review and meta-analysis. American journal of epidemiology 180, 29–40 (2014). · DOI · Paper page
  6. Forman, M. R., Mangini, L. D., Thelus-Jean, R. & Hayward, M. D. Life-course origins of the ages at menarche and menopause. Adolescent health, medicine and therapeutics 4, 1–21, doi:10.2147/AHMT.S15946 (2013). · DOI
  7. Ong, K. K. et al. Timing of voice breaking in males associated with growth and weight gain across the life course. J Clin Endocrinol Metab 97, 2844–2852, doi:10.1210/jc.2011-3445 (2012). · DOI
  8. Hardy, R., Kuh, D., Whincup, P. H. & Wadsworth, M. E. Age at puberty and adult blood pressure and body size in a British birth cohort study. Journal of hypertension 24, 59–66 (2006). · DOI
  9. Harries, M. L., Walker, J. M., Williams, D. M., Hawkins, S. & Hughes, I. A. Changes in the male voice at puberty. Archives of disease in childhood 77, 445–447 (1997). · DOI
  10. Juul, A., Magnusdottir, S., Scheike, T., Prytz, S. & Skakkebaek, N. E. Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend. International journal of andrology 30, 537–542 (2007). · DOI
  11. Allen, N. et al. UK Biobank: Current status and what it means for epidemiology. Health Policy and Technology 1, 123–126 (2012). · DOI · Paper page
  12. Stolk, L. et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature genetics 44, 260–268, doi:10.1038/ng.1051 (2012). · DOI · Paper page
  13. Parker, S. E. et al. Menarche, menopause, years of menstruation and the incidence of osteoporosis: the influence of prenatal exposure to diethylstilbestrol. J Clin Endocrinol Metab 99, 594–601, doi:10.1210/jc.2013-2954 (2014). · DOI
  14. Cooper, R. et al. Validity of age at menarche self-reported in adulthood. Journal of epidemiology and community health 60, 993–997 (2006). · DOI
  15. Ong, K. K. et al. Earlier mother's age at menarche predicts rapid infancy growth and childhood obesity. PLoS Med 4, e132, doi:10.1371/journal.pmed.0040132 (2007). · DOI
  16. Canoy, D. et al. Age at Menarche and Risks of Coronary Heart and Other Vascular Diseases in a Large UK Cohort. Circulation 131, 237–244, doi:10.1161/CIRCULATIONAHA.114.010070 (2015). · DOI · Paper page
  17. dos Santos Silva, I. et al. Prenatal factors, childhood growth trajectories and age at menarche. International journal of epidemiology 31, 405–412 (2002). · DOI
  18. Onland-Moret, N. C. et al. Age at menarche in relation to adult height: the EPIC study. American journal of epidemiology 162, 623–632 (2005). · DOI · Paper page
  19. Gaudineau, A. et al. Factors associated with early menarche: results from the French Health Behaviour in School-aged Children (HBSC) study. BMC public health 10, 175, doi:10.1186/1471-2458-10-175 (2010). · DOI
  20. Michaud, P. A., Suris, J. C. & Deppen, A. Gender-related psychological and behavioural correlates of pubertal timing in a national sample of Swiss adolescents. Molecular and cellular endocrinology 254-255, 172–178 (2006). · DOI
  21. Willemsen, R. H., Elleri, D., Williams, R. M., Ong, K. K. & Dunger, D. B. Pros and cons of GnRHa treatment for early puberty in girls. Nature reviews. Endocrinology, doi:10.1038/nrendo.2014.40 (2014). · DOI

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Metadata

Authors
Day, F. R., Elks, C. E., Murray, A., Ong, K. K., & Perry, J. R. B.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2015-06-18
Volume
5
Issue
1
Pages
11208-11208
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep11208
OpenAlex
W1594932835
Cited by
521
References
7
FWCI
38.66
Type
journal article
Language
en
Open access
gold
Licence

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CoChat. (2026). Citation check: Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. https://app.cochat.ai/papers/10.1038/srep11208
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Day, F. R., Elks, C. E., Murray, A., Ong, K. K., & Perry, J. R. B. (2015). Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. Scientific Reports. https://doi.org/10.1038/srep11208

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.