Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression
Open accessAbstract
Although cell-in-cell structures (CICs) could be detected in a wide range of human tumors, homotypic CICs formed between tumor cells occur at low rate for most of them. We recently reported that tumor cells lacking expression of E- and P-cadherin were incapable of forming homotypic CICs by entosis and re-expression of E- or P-cadherin was sufficient to induce CICs formation in these tumor cells. In this work, we found that homotypic CICs formation was impaired in some tumor cells expressing high level of E-cadherin due to loss expression of alpha-catenin (α-catenin), a molecular linker between cadherin-mediated adherens junctions and F-actin. Expression of α-catenin in these tumor cells restored cell-cell adhesion and promoted CICs formation in a ROCK kinase-dependent way. Thus, our work identified α-catenin as another molecule in addition to E- and P-cadherin that were targeted to inactivate homotypic CICs formation in human tumor cells.
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Uptake of entotic cells is an integrin-independent process promoted by formation of junctions between engulfing and entotic cells involving CDH1 and CTNNA1.
“the uptake of entotic cells is an integrin-independent process promoted by the formation of junctions between engulfing and entotic cells that involve the adhesion proteins cadherin 1 (CDH1; also known as E-cadherin) and catenin alpha 1 (CTNNA1) [694, 699].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [699]
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- Authors
- Wang, M., Ning, X., Chen, A., Huang, H., Ni, C., Zhou, C., Yu, K., Lan, S., Wang, Q., Li, S., Liu, H., Wang, X., Chen, Z., Ma, L., & Sun, Q.
- Affiliations
- Southern Medical University (CN)
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- Academy of Military Medical Sciences (CN)
- Second Military Medical University (CN)
- Corresponding author
- Chen, Zhaolie
- Ma, Li
- Sun, Qiang
- Venue
- Scientific Reports
- Published
- 2015-07-20
- Volume
- 5
- Issue
- 1
- Pages
- 12223-12223
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4648412
- OpenAlex
- W2271849284
- Cited by
- 54
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 9 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 2
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81471578, 81472588, 81371764)
- National Key Research and Development Program of China (2015CB553704)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- cell-in-cell structures, alpha-catenin, entosis, E-cadherin, P-cadherin, adherens junctions, cell-cell adhesion, ROCK kinase, cancer cells, F-actin
- MeSH terms
- Actins, Cell Adhesion, Cytoskeleton, Humans, Adherens Junctions, Cell Line, Tumor, alpha Catenin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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