Mechanisms and consequences of entosis
Open accessAbstract
Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
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Internalization in entosis is often but not always followed by demise of internalized cells.
“Often (but not always), internalization is followed by the demise of internalized cells (which are commonly referred to as “entotic cells”) [691–693].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [691]
The current model proposes that internalization of entotic cells occurs through cell invasion rather than by phagocytosis.
“The current model proposes that the internalization of entotic cells occurs through cell invasion rather than by phagocytosis [691].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [691]
Entosis is a form of cell cannibalism occurring in healthy and malignant mammalian tissues, involving engulfment of viable cells by non-phagocytic cells of the same or a different type.
“Entosis is a form of cell cannibalism that occurs in healthy and malignant mammalian tissues, involving the engulfment of viable cells by non-phagocytic cells of the same (homotypic) or a different (heterotypic) type [691, 692].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [691]
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Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinomaPreprint
Basbous, S., Dif, L., Dantzer, C., Di-Tommaso, S., Dupuy, J., Bioulac‐Sage, P., Raymond, A., Desdouets, C., Saltel, F., & Moreau, V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.01.555890
- Authors
- Krishna, S., & Overholtzer, M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Overholtzer, Michael
- ORCID
- Overholtzer, Michael
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-04-05
- Volume
- 73
- Issue
- 11-12
- Pages
- 2379-2386
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC4889469
- OpenAlex
- W2331432060
- Cited by
- 118
- References
- 65
- Citations by year
- 2026: 2 · 2025: 19 · 2024: 13 · 2023: 17 · 2022: 6 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Cancer Institute (R01CA154649)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- entosis, cell-in-cell structures, cell engulfment, carcinogenesis, development (biology), cell population dynamics
- MeSH terms
- Autophagy, Humans, Neoplasms, Phagocytosis, Apoptosis, Entosis, Carcinogenesis
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