Parity and Cardiovascular Disease Mortality: a Dose-Response Meta-Analysis of Cohort Studies
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Parity has been shown to inversely associate with cardiovascular disease (CVD) mortality, but the evidence of epidemiological studies is still controversial. Therefore, we quantitatively assessed the relationship between parity and CVD mortality by summarizing the evidence from prospective studies. We searched MEDLINE (PubMed), EMBASE and ISI Web of Science databases for relevant prospective studies of parity and CVD mortality through the end of March 2015. Fixed- or random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I2 statistics. All statistical tests were two-sided. Ten prospective studies were included with a total of 994,810 participants and 16,601 CVD events. A borderline significant inverse association was observed while comparing parity with nulliparous, with summarized RR = 0.79 (95% CI: 0.60–1.06; I2 = 90.9%, P < 0.001). In dose-response analysis, we observed a significant nonlinear association between parity number and CVD mortality. The greatest risk reduction appeared when the parity number reached four. The findings of this meta-analysis suggests that ever parity is inversely related to CVD mortality. Furthermore, there is a statistically significant nonlinear inverse association between parity number and CVD mortality.
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Mortality from composite cardiovascular disease is lower in ever parous women than in nulliparous women.
“Mortality from composite cardiovascular disease was lower in ever parous women than nulliparous women (table 1).89”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [89]
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- Authors
- Lv, H., Wu, H., Yin, J., Qian, J., & Ge, J.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Ge, Junbo
- Venue
- Scientific Reports
- Published
- 2015-08-24
- Volume
- 5
- Issue
- 1
- Pages
- 13411-13411
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4547137
- OpenAlex
- W2436855732
- Cited by
- 72
- References
- 35
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 2 · 2016: 2
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81300152)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- parity, cardiovascular mortality, nulliparity, dose-response relationship, nonlinear relationship, maternal reproductive history, cardiovascular risk
- MeSH terms
- Adult, Cardiovascular Diseases, Female, Humans, Middle Aged, Parity, Pregnancy, Risk Factors, Cohort Studies, Parturition, Young Adult
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