Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Obesity alters gut microbial ecology

Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works

Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species

Kim, O.-S., Cho, Y., Lee, K., Yoon, S.-H., Kim, M., Na, H., Park, S., Jeon, Y. S., Lee, J., Yi, H., et al. (2011) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.038075-0 · Cited by 5,214 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294 · see citing works

The role of the gut microbiota in nutrition and health

Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,203 · see citing works

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · see citing works

EzTaxon: a web-based tool for the identification of prokaryotes based on 16S ribosomal RNA gene sequences

Chun, J., Lee, J., Jung, Y., Kim, M., Kim, S., Kim, B. K., & Lim, Y. (2007) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.64915-0 · Cited by 2,096 · see citing works

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

György, B., Szabó, T. G., Pásztói, M., Pál, Z., Misják, P., Aradi, B., László, V., Pállinger, É., Pap, E., Kittel, Á., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0689-3 · Cited by 2,075 · see citing works

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

Optimal alignments in linear space

Myers, E. W., & Miller, W. (1988) · Computer applications in the biosciences · doi:10.1093/bioinformatics/4.1.11 · Cited by 1,241 · see citing works

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Bobrie, A., Colombo, M., Raposo, G., & Théry, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01225.x · Cited by 1,102 · see citing works

Signaling pathways in insulin action: molecular targets of insulin resistance

Pessin, J. E., & Saltiel, A. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10582 · Cited by 939 · see citing works

Membrane vesicles traffic signals and facilitate group activities in a prokaryote

Mashburn, L. M., & Whiteley, M. (2005) · Nature · doi:10.1038/nature03925 · Cited by 844 · see citing works

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works

Gram‐positive bacteria produce membrane vesicles: Proteomics‐based characterization of Staphylococcus aureus ‐derived membrane vesicles

Lee, E., Choi, D., Kim, D., Kim, J., Park, J. O., Kim, S., Kim, S., Desiderio, D. M., Kim, Y., Kim, K. P., et al. (2009) · PROTEOMICS · doi:10.1002/pmic.200900338 · Cited by 672 · see citing works

Chylomicrons promote intestinal absorption of lipopolysaccharides

Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works

EVpedia: an integrated database of high‐throughput data for systemic analyses of extracellular vesicles

Kim, D., Kang, B., Kim, O. Y., Choi, D., Lee, J., Kim, S. R., Go, G., Yoon, Y. J., Kim, J. H., Jang, S. C., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20384 · Cited by 566 · see citing works

Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding.

Harding, C. V., Heuser, J., & Stahl, P. D. (1984) · PubMed · Cited by 415 · see citing works

Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli

Lee, E., Bang, J. Y., Park, G. W., Choi, D., Kang, J. S., Kim, H., Park, K., Lee, J., Kim, Y., Kwon, K., et al. (2007) · PROTEOMICS · doi:10.1002/pmic.200700196 · Cited by 410 · see citing works

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

for the D.E.S.I.R. Study Group, Amar, J., Sérino, M., Lange, C., Chabo, C., Iacovoni, J. S., Mondot, S., Lepage, P., Klopp, C., Mariette, J., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2329-8 · Cited by 327 · see citing works

GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay

Wang, Q., Khayat, Z. A., Kishi, K., Ebina, Y., & Klip, A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00423-2 · Cited by 219 · see citing works

Stimulation of Glucose Uptake by the Natural Coenzyme α-Lipoic Acid/Thioctic Acid: Participation of Elements of the Insulin Signaling Pathway

ESTRADA, D. E., Ewart, H. S., Tsakiridis, T. K., Volchuk, A., Ramlal, T., Tritschler, H., & Klip, A. (1996) · Diabetes · doi:10.2337/diab.45.12.1798 · Cited by 199 · see citing works

Honor Thy Gut Symbionts Redux

Gordon, J. I. (2012) · Science · doi:10.1126/science.1224686 · Cited by 172 · see citing works

Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2

Wei, X., YANG, Z. K., Rey, F. E., Ridaura, V. K., Davidson, N. O., Gordon, J. I., & Semenkovich, C. F. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2011.12.006 · Cited by 162 · see citing works

S taphylococcus aureus‐derived extracellular vesicles induce neutrophilic pulmonary inflammation via both T h1 and T h17 cell responses

Kim, M. ‐., Hong, S., Choi, E. B., Lee, W. H., Kim, Y. ‐., Jeon, S. G., Jang, M. H., Gho, Y. S., & Kim, Y. ‐. (2012) · Allergy · doi:10.1111/all.12001 · Cited by 155 · see citing works

CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice

Kim, D., Kim, J. J., Yoon, J. H., Ghim, J., Yea, K., Song, P., Park, S., Lee, A.-R., Hong, C. P., Jang, M. S., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3237-5 · Cited by 144 · see citing works

Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase*

Song, P., Kim, J. H., Ghim, J., Yoon, J. H., Lee, A., Kwon, Y., Hyun, H., Moon, H. Y., Choi, H., Berggren, P., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.441477 · Cited by 79 · see citing works

Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot, C., Choi, Y., Kim, D., Park, H. T., Ghim, J., Kwon, Y., Jeon, J., Kim, M.-S., Jee, Y., Gho, Y. S., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.282 · Cited by 859 · see citing works

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Li, C., Ni, Y., Xu, H., Xiang, Q., Zhao, Y. Q., Zhan, J., He, J., Li, S., & Liu, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 407 · see citing works

Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis

Grosicki, G. J., Fielding, R. A., & Lustgarten, M. S. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0345-5 · Cited by 388 · see citing works

Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength

Liu, J., Chen, C., Liu, Z., Luo, Z., Rao, S., Jin, L., Wan, T., Yue, T., Tan, Y., Yin, H., et al. (2021) · Advanced Science · doi:10.1002/advs.202004831 · Cited by 256 · see citing works

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

Macia, L., Nanan, R. K. H., Beheshti, E. H., & Grau, G. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010107 · Cited by 240 · see citing works

Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis

Chen, C., Rao, S., Yue, T., Tan, Y., Yin, H., Chen, L.-J., Luo, M., Wang, Z., Wang, Y., Hong, C., et al. (2022) · Science Advances · doi:10.1126/sciadv.abg8335 · Cited by 210 · see citing works

Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 194 · see citing works

Extracellular vesicles in metabolic disease

Akbar, N., Azzimato, V., Choudhury, R. P., & Aouadi, M. (2019) · Diabetologia · doi:10.1007/s00125-019-05014-5 · Cited by 191 · see citing works

Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo

Bittel, M., Reichert, P., Sarfati, I., Dressel, A., Leikam, S., Uderhardt, S., Stolzer, I., Phu, T. A., Ng, M., Vu, N. K., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12159 · Cited by 180 · see citing works

Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome?

Miri, S., Yeo, J., Abubaker, S., & Hammami, R. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1098412 · Cited by 167 · see citing works

Metagenome Analysis of Bodily Microbiota in a Mouse Model of Alzheimer Disease Using Bacteria-derived Membrane Vesicles in Blood

Park, J. Y., Choi, J., Lee, Y., Lee, J.-E., Lee, E. H., Kwon, H.-J., Yang, J., Jeong, B.-R., Kim, Y., & Han, P. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.6.369 · Cited by 148 · see citing works

Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver

Seyama, M., Yoshida, K., Yoshida, K., Fujiwara, N., Ono, K., Eguchi, T., Kawai, H., Guo, J., Weng, Y., Haoze, Y., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165731 · Cited by 148 · see citing works

Extracellular Vesicles in Metabolic Syndrome

Martínez, M. C., & Andriantsitohaina, R. (2017) · Circulation Research · doi:10.1161/circresaha.117.309419 · Cited by 142 · see citing works

Helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells

Choi, H.-I., Choi, J., Seo, J. W., Kim, B. J., Rho, M., Han, J. K., & Kim, J. G. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.47 · Cited by 135 · see citing works

Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet

Díez-Sainz, E., Milagro, F. I., Riezu‐Boj, J. I., & Lorente‐Cebrián, S. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00837-6 · Cited by 104 · see citing works

Mechanisms Linking the Gut-Muscle Axis With Muscle Protein Metabolism and Anabolic Resistance: Implications for Older Adults at Risk of Sarcopenia

Prokopidis, K., Chambers, E. S., Lochlainn, M. N., & Witard, O. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.770455 · Cited by 109 · see citing works

Microvesicles and exosomes in metabolic diseases and inflammation

Dini, L., Tacconi, S., Carata, E., Tata, A. M., Vergallo, C., & Panzarini, E. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.12.008 · Cited by 96 · see citing works

Role of extracellular vesicles in liver diseases and their therapeutic potential

Kostallari, E., Valainathan, S. R., Biquard, L., Shah, V. H., & Rautou, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.026 · Cited by 92 · see citing works

Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers

Kim, S. Y., & Yi, D. Y. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0470-5 · Cited by 92 · see citing works

Potential Mechanisms Linking Food-Derived MicroRNAs, Gut Microbiota and Intestinal Barrier Functions in the Context of Nutrition and Human Health

Díez-Sainz, E., Lorente‐Cebrián, S., Aranaz, P., Riezu‐Boj, J. I., Martínez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.586564 · Cited by 92 · see citing works

Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles

Kaisanlahti, A., Turunen, J., Byts, N., Samoylenko, A., Bart, G., Virtanen, N., Tejesvi, M. V., Zhyvolozhnyi, A., Sarfraz, S., Kumpula, S., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01694-9 · Cited by 87 · see citing works

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

Kim, D. J., Yoon, S., Ji, S. C., Yang, J., Kim, Y., Lee, S., Yu, K., Jang, I., Chung, J., & Cho, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-30349-1 · Cited by 87 · see citing works

miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene

Kumar, A., Ren, Y., Sundaram, K., Mu, J., Sriwastva, M. K., Dryden, G. W., Lei, C., Zhang, L., Yan, J., Zhang, X., et al. (2021) · Theranostics · doi:10.7150/thno.52558 · Cited by 80 · see citing works

Beneficial Effects of Potentilla discolor Bunge Water Extract on Inflammatory Cytokines Release and Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice

Han, L., Li, T., Du, ‬., Chang, R., Zhan, B., & Mao, X. (2019) · Nutrients · doi:10.3390/nu11030670 · Cited by 79 · see citing works

The PPAR–microbiota–metabolic organ trilogy to fine‐tune physiology

Oh, H. Y. P., Visvalingam, V., & Wahli, W. (2019) · The FASEB Journal · doi:10.1096/fj.201802681rr · Cited by 78 · see citing works

Maternal Microbiome and Infections in Pregnancy

Amir, M., Brown, J. A., Rager, S. L., Sanidad, K. Z., Ananthanarayanan, A., & Zeng, M. Y. (2020) · Microorganisms · doi:10.3390/microorganisms8121996 · Cited by 78 · see citing works

Faeces‐derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases

Fizanne, L., Villard, A., Benabbou, N., Recoquillon, S., Soleti, R., Delage, E., Wertheimer, M., Vidal‐Gómez, X., Oullier, T., Chaffron, S., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12303 · Cited by 73 · see citing works

The impact of bacteria-derived ultrafine dust particles on pulmonary diseases

Yang, J., Kim, E. K., Park, H. J., McDowell, A., & Kim, Y. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0367-3 · Cited by 71 · see citing works

A new horizon of precision medicine: combination of the microbiome and extracellular vesicles

Yang, J., Shin, T.-S., Kim, J. S., Jee, Y., & Kim, Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00748-6 · Cited by 72 · see citing works

Bacterial extracellular vesicles: A position paper by the microbial vesicles task force of the Chinese society for extracellular vesicles

Wen, M., Wang, J., Ou, Z., Nie, G., Chen, Y., Li, M., Wu, Z., Xiong, S., Zhou, H., Yang, Z., et al. (2023) · Interdisciplinary medicine · doi:10.1002/inmd.20230017 · Cited by 70 · see citing works

Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications

Liu, J., Zhang, Y., Tian, Y., Huang, W. C., Tong, N., & Fu, X. (2022) · Theranostics · doi:10.7150/thno.65778 · Cited by 69 · see citing works

Gut Microbiota Extracellular Vesicles as Signaling Molecules Mediating Host-Microbiota Communications

Sultan, S., Mottawea, W., Yeo, J., & Hammami, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313166 · Cited by 68 · see citing works

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

Khalyfa, A., Poroyko, V. A., Qiao, Z., Gileles‐Hillel, A., Khalyfa, A. A., Akbarpour, M., Almendros, I., Farré, R., & Gozal, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00882 · Cited by 64 · see citing works

Microbiota dysbiosis and functional outcome in acute ischemic stroke patients

Chang, Y., Woo, H. G., Jeong, J. H., Kim, G. H., Park, K. D., & Song, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-90463-5 · Cited by 59 · see citing works

Exosomes and Obesity-Related Insulin Resistance

Lei, L.-M., Lin, X., Xu, F., Shan, S., Guo, B., Li, F., Zheng, M.-H., Wang, Y., Xu, Q.-S., & Yuan, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651996 · Cited by 57 · see citing works

Extracellular Vesicles: New Players in Lung Immunity

Fujita, Y., Kadota, T., Araya, J., Ochiya, T., & Kuwano, K. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0293tr · Cited by 57 · see citing works

Altered Composition of Microbiota in Women with Ovarian Endometrioma: Microbiome Analyses of Extracellular Vesicles in the Peritoneal Fluid

Lee, S. R., Lee, J., Kim, S.-H., Oh, Y. S., Chae, H. D., Seo, H., Kang, C.-S., & Shin, T.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094608 · Cited by 56 · see citing works

Gut microbes-muscle axis in muscle function and meat quality

He, Y., Hu, H., Liang, X., Liang, J., Li, F., & Zhou, X. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2885-4 · Cited by 57 · see citing works

The Role of Bacterial Membrane Vesicles in Human Health and Disease

Villageliú, D. N., & Samuelson, D. R. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.828704 · Cited by 54 · see citing works

Mechanisms linking gut microbial metabolites to insulin resistance

Jang, H. R., & Lee, H. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i6.730 · Cited by 52 · see citing works

Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview

Hadizadeh, N., Bagheri, D., Shamsara, M., Hamblin, M. R., Farmany, A., Xu, M., Liang, Z., Razi, F., & Hashemi, E. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1019821 · Cited by 49 · see citing works

Alterations in Gut Microbiota and Immunity by Dietary Fat

Yang, B., Hur, K. Y., & Lee, M. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.6.1083 · Cited by 49 · see citing works

Immunoregulatory effects of Lactococcus lactis‐derived extracellular vesicles in allergic asthma

Lee, D., Park, H., Lee, H., Sohn, H., Sim, S., Park, H. J., Shin, Y. S., Kim, Y., Choi, Y., & Park, H. (2022) · Clinical and Translational Allergy · doi:10.1002/clt2.12138 · Cited by 49 · see citing works

Dysbiotic Gut Microbiota-Derived Metabolites and Their Role in Non-Communicable Diseases

Tan, J., Taitz, J., Nanan, R. K. H., Grau, G. E., & Macia, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015256 · Cited by 56 · see citing works

Characterization of the gut microbiota in frail elderly patients

Zhang, L., Liao, J., Chen, Q., Chen, M., Kuang, Y., Chen, L., & Wen, H. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01385-2 · Cited by 47 · see citing works

Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study

Yang, J., McDowell, A., Seo, H., Kim, S., Min, T. K., Jee, Y., Choi, Y., Park, H., Pyun, B. Y., & Kim, Y. (2020) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.5.792 · Cited by 47 · see citing works

Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis?

Villard, A., Boursier, J., & Andriantsitohaina, R. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00362.2020 · Cited by 46 · see citing works

The Fruits of Paris polyphylla Inhibit Colorectal Cancer Cell Migration Induced by Fusobacterium nucleatum-Derived Extracellular Vesicles

Lin, L., Shi, Y.-C., Choong, C.-Y., & Tai, C. (2021) · Molecules · doi:10.3390/molecules26134081 · Cited by 47 · see citing works

The Potential Role of Gut Microbial-Derived Exosomes in Metabolic-Associated Fatty Liver Disease: Implications for Treatment

Zhang, B., Zhao, J., Jiang, M., Peng, D., Dou, X., Song, Y., & Shi, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.893617 · Cited by 45 · see citing works

Role of an unclassified Lachnospiraceae in the pathogenesis of type 2 diabetes: a longitudinal study of the urine microbiome and metabolites

Kim, K., Lee, S., Park, S.-C., Kim, N.-E., Shin, C., Lee, S. K., Jung, Y., Yoon, D., Kim, H.-J., Kim, S., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00816-x · Cited by 45 · see citing works

NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism

Ren, Z., Xu, Y., Li, T., Sun, W., Tang, Z., Wang, Y., Zhou, K., Li, J., Ding, Q., Liang, K., et al. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2022.06.009 · Cited by 44 · see citing works

Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome

Niu, G., Jian, T., Gai, Y., & Chen, J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114774 · Cited by 44 · see citing works

Characterization of Feces-Derived Bacterial Membrane Vesicles and the Impact of Their Origin on the Inflammatory Response

Kameli, N., Borman, R., López‐Iglesias, C., Savelkoul, P. H. M., & Stassen, F. R. M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.667987 · Cited by 44 · see citing works

Circulating 16S RNA in Biofluids: Extracellular Vesicles as Mirrors of Human Microbiome?

Ricci, V., Carcione, D., Messina, S., Colombo, G. I., & D’Alessandra, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238959 · Cited by 43 · see citing works

The potential role of gut microbiota-derived metabolites as regulators of metabolic syndrome-associated mitochondrial and endolysosomal dysfunction in Alzheimer’s disease

Jung, Y. H., Chae, C. W., & Han, H. J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01282-3 · Cited by 42 · see citing works

Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling

Mottawea, W., Yousuf, B., Sultan, S., Ahmed, T. A., Yeo, J., Hüttmann, N., Li, Y., Bouhlel, N. E., Hassan, H., Zhang, X., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01368-24 · Cited by 44 · see citing works

Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities

Luo, R., Chang, Y., Liang, H., Zhang, W., Song, Y., Li, G., & Cao, Y. (2023) · iMeta · doi:10.1002/imt2.86 · Cited by 41 · see citing works

Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications

García-Gutiérrez, E., O’Mahony, A. K., dos Santos, R. S., Marroquí, L., & Cotter, P. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2401654 · Cited by 42 · see citing works

The Gut Microbiota-Related Antihyperglycemic Effect of Metformin

Szymczak-Pajor, I., Drzewoski, J., Kozłowska, M., Krekora, J., & Śliwińska, A. (2025) · Pharmaceuticals · doi:10.3390/ph18010055 · Cited by 41 · see citing works

16S rDNA microbiome composition pattern analysis as a diagnostic biomarker for biliary tract cancer

Lee, H., Lee, W. H., Min, S. K., & Lee, W. H. (2020) · World Journal of Surgical Oncology · doi:10.1186/s12957-020-1793-3 · Cited by 41 · see citing works

Bacterial Extracellular Vesicles in Gastrointestinal Tract Cancer: An Unexplored Territory

Amatya, S. B., Salmi, S., Kainulainen, V., Karihtala, P., & Reunanen, J. (2021) · Cancers · doi:10.3390/cancers13215450 · Cited by 42 · see citing works

Polysaccharides isolated from Cordyceps Sinensis contribute to the progression of NASH by modifying the gut microbiota in mice fed a high-fat diet

Chen, L., Zhang, L., Wang, W., Qiu, W., Liu, L., Ning, A., Cao, J., Huang, M., & Zhong, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232972 · Cited by 40 · see citing works

From trash to treasure: the role of bacterial extracellular vesicles in gut health and disease

Sun, D., Chen, P., Xi, Y., & Sheng, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1274295 · Cited by 39 · see citing works

Microbiota‐derived extracellular vesicles and metabolic syndrome

Villard, A., Boursier, J., & Andriantsitohaina, R. (2020) · Acta Physiologica · doi:10.1111/apha.13600 · Cited by 38 · see citing works

Roles of bacterial extracellular vesicles in systemic diseases

Wang, Y., Luo, X., Xiang, X., Hao, C., & Ma, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1258860 · Cited by 38 · see citing works

Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation

Ofir‐Birin, Y., Heidenreich, M., & Regev‐Rudzki, N. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.03.004 · Cited by 38 · see citing works

Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications

Choi, Y., Sim, S., & Park, H. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.022 · Cited by 37 · see citing works

The Characteristics, Mechanisms and Therapeutics: Exploring the Role of Gut Microbiota in Obesity

Zhuang, Z., Zhou, P., Wang, J., Lu, X., & Chen, Y. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s432344 · Cited by 36 · see citing works

Extracellular Vesicles: A Novel Target for Exercise-Mediated Reductions in Type 2 Diabetes and Cardiovascular Disease Risk

Eichner, N. Z. M., Erdbrügger, U., & Malin, S. K. (2018) · Journal of Diabetes Research · doi:10.1155/2018/7807245 · Cited by 35 · see citing works

Type-2 Diabetics Reduces Spatial Variation of Microbiome Based on Extracellur Vesicles from Gut Microbes across Human Body

Nah, G., Park, S.-C., Kim, K., Kim, S., Park, J., Lee, S., & Won, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-56662-x · Cited by 37 · see citing works

Green Tea Encourages Growth of Akkermansia muciniphila

Jeong, H. W., Kim, J. K., Kim, A. Y., Cho, D., Lee, J., Choi, J. K., Park, M., & Kim, W.-G. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4662 · Cited by 37 · see citing works

Diversity in the Extracellular Vesicle-Derived Microbiome of Tissues According to Tumor Progression in Pancreatic Cancer

Jeong, J., Kim, T., Kim, J., Choi, H. W., Kim, E. J., Yoo, H. J., Lee, S., Jun, H. R., Yoo, W., Kim, S., et al. (2020) · Cancers · doi:10.3390/cancers12092346 · Cited by 36 · see citing works

Brain tumor diagnostic model and dietary effect based on extracellular vesicle microbiome data in serum

Yang, J., Moon, H. E., Park, H. W., McDowell, A., Shin, T.-S., Jee, Y., Kym, S., Paek, S. H., & Kim, Y. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00501-x · Cited by 36 · see citing works

Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota

Liu, Y., Xu, L., Yang, Z., Wang, D., Li, T., Yang, F., Li, Z., Bai, X., & Wang, Y.-C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114837 · Cited by 35 · see citing works

The Emerging Roles of Microparticles in Diabetic Nephropathy

Lu, C., Ma, K. L., Ruan, X. Z., & Liu, B. C. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.21140 · Cited by 31 · see citing works

Targeting the Gut Microbiota to Improve Dietary Protein Efficacy to Mitigate Sarcopenia

Castro, E. D. M., Murphy, C. H., & Roche, H. M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.656730 · Cited by 31 · see citing works

Bacterial membrane vesicles and phages in blood after consumption of Lacticaseibacillus rhamnosus JB-1

Champagne-Jorgensen, K. P., Jose, T. A., Stanisz, A. M., Mian, M. F., Hynes, A. P., & Bienenstock, J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1993583 · Cited by 31 · see citing works

Preliminary Evidences of Safety and Efficacy of Flavonoids- and Omega 3-Based Compound for Muscular Dystrophies Treatment: A Randomized Double-Blind Placebo Controlled Pilot Clinical Trial

Sitzia, C., Meregalli, M., Belicchi, M., Farini, A., Arosio, M., Bestetti, D., Villa, C., Valenti, L. V. C., Brambilla, P., & Torrente, Y. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00755 · Cited by 30 · see citing works

An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases

Filip, R. (2021) · Cells · doi:10.3390/cells10113202 · Cited by 29 · see citing works

Extracellular vesicles derived from host and gut microbiota as promising nanocarriers for targeted therapy in osteoporosis and osteoarthritis

Cheung, K. C.-P., Ma, J., Xingxuan, C., & Jia, W. P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1051134 · Cited by 33 · see citing works

Diet, commensal microbiota‐derived extracellular vesicles, and host immunity

Taitz, J., Tan, J. K., Potier‐Villette, C., Ni, D., King, N. J. C., Nanan, R. K. H., & Macia, L. (2023) · European Journal of Immunology · doi:10.1002/eji.202250163 · Cited by 29 · see citing works

Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?

Choi, Y., Lee, Y., & Park, H. (2019) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2019.11.3.320 · Cited by 29 · see citing works

Bacterial extracellular vesicles: emerging mediators of gut-liver axis crosstalk in hepatic diseases

Zhou, Y.-T., Sun, Y., Yin, P., Zuo, S., Li, H., & Cao, K. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1620829 · Cited by 31 · see citing works

Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation

Hegde, M., Kumar, A., Girisa, S., Alqahtani, M. S., Abbas, M. A. E., Goel, A., Hui, K. M., Sethi, G., & Kunnumakkara, A. B. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.06.001 · Cited by 28 · see citing works

LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4

Ali, S., Malloci, M., Safiedeen, Z., Soleti, R., Vergori, L., Vidal‐Gómez, X., Besnard, C., Dubois, S. G., Lay, S. L., Boursier, J., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154727 · Cited by 27 · see citing works

Microbiota-derived extracellular vesicles: current knowledge, gaps, and challenges in precision nutrition

Marquez‐Paradas, E., Torrecillas-López, M., Barrera‐Chamorro, L., Rio-Vazquez, J. L. D., la Rosa, T. G., & la Paz, S. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1514726 · Cited by 26 · see citing works

The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease

Nassir, C. M. N. C. M., Ramli, M. D. C., Ghazali, M. M., Jaffer, U., Hamid, H. A., Mehat, M. Z., & Hein, Z. M. (2024) · Life · doi:10.3390/life15010003 · Cited by 28 · see citing works

Composition Analysis of Airborne Microbiota in Outdoor and Indoor Based on Dust Separated by Micro-sized and Nano-sized

Yang, J., Seo, J., Jee, Y., Kim, Y., & Sohn, J. (2023) · Aerosol and Air Quality Research · doi:10.4209/aaqr.210231 · Cited by 24 · see citing works

HLF and PPARα axis regulates metabolic‐associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota

Yang, X., Wang, J., Qi, X., Hou, M., Liu, M., Yang, X. Y., Liu, S., Zhou, J., Yu, J., Wang, Y., et al. (2025) · iMeta · doi:10.1002/imt2.70022 · Cited by 24 · see citing works

Sepsis-Induced Myopathy and Gut Microbiome Dysbiosis: Mechanistic Links and Therapeutic Targets

Mankowski, R. T., Laitano, O., Darden, D. B., Kelly, L. S., Munley, J. A., Loftus, T. J., Mohr, A. M., Efron, P. A., & Thomas, R. M. (2021) · Shock · doi:10.1097/shk.0000000000001843 · Cited by 25 · see citing works

Micrococcus luteus-derived extracellular vesicles attenuate neutrophilic asthma by regulating miRNAs in airway epithelial cells

Sim, S., Lee, D., Kim, K.-S., Park, H. J., Kim, Y., Choi, Y., & Park, H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00910-0 · Cited by 23 · see citing works

Consumption of a Leuconostoc holzapfelii-enriched synbiotic beverage alters the composition of the microbiota and microbial extracellular vesicles

Yang, J., McDowell, A., Kim, E. K., Seo, H., Yum, K., Lee, W. H., Jee, Y., & Kim, Y. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0288-1 · Cited by 23 · see citing works

Gut-bacteria derived membrane vesicles and host metabolic health: a narrative review

Verbunt, J., Jocken, J. W. E., Blaak, E. E., Savelkoul, P. H. M., & Stassen, F. R. M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359515 · Cited by 22 · see citing works

Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals

Gaundal, L., Myhrstad, M. C. W., Rud, I., Gjøvaag, T. F., Byfuglien, M. G., Retterstøl, K., Holven, K. B., Ulven, S. M., & Telle‐Hansen, V. H. (2022) · Food & Nutrition Research · doi:10.29219/fnr.v66.8580 · Cited by 22 · see citing works

Gut–Adipose Tissue Axis and Metabolic Health

Borozan, S., Fernandez, C. J., Samee, A., & Pappachan, J. M. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47060424 · Cited by 21 · see citing works

Toxic ties: Unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease

Nayak, S. P. R. R., Boopathi, S., Haridevamuthu, B., & Arockiaraj, J. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122686 · Cited by 21 · see citing works

Gut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parameters

Lee, H.-K., Kim, N.-E., Shin, C. M., Oh, T. J., Yoon, H., Park, Y. S., Kim, N., Won, S., & Lee, D. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-53837-z · Cited by 22 · see citing works

Food‐derived extracellular vesicles in the human gastrointestinal tract: Opportunities for personalised nutrition and targeted therapeutics

Turner, N. P. (2024) · Journal of Extracellular Biology · doi:10.1002/jex2.154 · Cited by 20 · see citing works

The global patent landscape of functional food innovation

Matin, M., Hrg, D., Litvinova, O., Łysek-Gładysińska, M., Wierzbicka, A., Horbańczuk, J. O., Jóźwik, A., & Atanasov, A. G. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02410-0 · Cited by 20 · see citing works

Mechanistic Links Between Gut Dysbiosis, Insulin Resistance, and Autism Spectrum Disorder

Guevara‐Ramírez, P., Tamayo‐Trujillo, R., Ruiz‐Pozo, V. A., Cadena-Ullauri, S., Paz‐Cruz, E., & Zambrano, A. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136537 · Cited by 20 · see citing works

Type-2 Diabetics Reduces Spatial Variation of Microbiome Based on Extracellur Vesicles from Gut Microbes across Human Body

Nah, G., Park, S.-C., Kim, K., Kim, S., Park, J., Lee, S., & Won, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-56662-x · Cited by 37 · see citing works

Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet

Díez-Sainz, E., Milagro, F. I., Riezu‐Boj, J. I., & Lorente‐Cebrián, S. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00837-6 · Cited by 104 · see citing works

Extracellular vesicles from obese and diabetic mouse plasma alter C2C12 myotube glucose uptake and gene expression

Pitzer, C. R., Paez, H. G., Ferrandi, P. J., Mohamed, J. S., & Alway, S. E. (2024) · Physiological Reports · doi:10.14814/phy2.15898 · Cited by 4 · see citing works

Extracellular vesicles from Akkermansia muciniphila protect streptozotocin-induced diabetic mice by regulating glucose homeostasis, oxidative stress, and immune tolerance

Chang, Y., Zhang, C., Li, Z., Wang, S., Wu, J., Xie, J., & Cheng, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1739048 · Cited by 2 · see citing works

Pasteurized Bacteroides thetaiotaomicron and its extracellular vesicles improve metabolic profiles, expression of genes associated with diabetes and inflammation, and gut microbiota in type 2 diabetic rats

Hasanian‑Langroudi, F., Hedayati, M., Ghasemi, A., Siadat, S. D., & Tohidi, M. (2025) · EXCLI journal · doi:10.17179/excli2025-8860 · Cited by 1 · see citing works