Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats
Open accessAbstract
This study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing (2 nd lumbar vertebra and calvarium) bones in the context of ovarian hormone insufficiency. 12-week-old Fisher 344 rats were ovariectomized 2 weeks before flight and randomized into one of three groups: 1) baseline (n = 6), 2) ground control (n = 12) or 3) spaceflight (n = 12). Additional ground-based ovary-intact rats provided age-matched reference values at baseline (n = 8) and landing (n = 10). Ovariectomy resulted in bone- and bone compartment-specific deficits in cancellous bone volume fraction. Spaceflight resulted in lower cortical bone accrual in the femur but had no effect on cortical bone in the humerus or calvarium. Cancellous bone volume fraction was lower in flight animals compared to ground control animals in lumbar vertebra and distal femur metaphysis and epiphysis; significant differences were not detected in the distal humerus. Bone loss (compared to baseline controls) in the femur metaphysis was associated with lower trabecular number, whereas trabecular thickness and number were lower in the epiphysis. In summary, the effect of spaceflight on bone microarchitecture in ovariectomized rats was bone-and bone compartment-specific but not strictly related to weight bearing.
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BMD in the humerus was not reduced in flight mice during the 22 d period.
“Interestingly, BMD in the humerus was not reduced in flight mice during this 22 d period, consistent with the differential effects of microgravity on the femur and humerus reported in rats (26) and humans (27).”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [26]
Differential effects of microgravity on the femur and humerus have been reported in rats and humans.
“Interestingly, BMD in the humerus was not reduced in flight mice during this 22 d period, consistent with the differential effects of microgravity on the femur and humerus reported in rats (26) and humans (27).”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [26]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90338-v · Cited by 7,153 · see citing works
Guidelines for assessment of bone microstructure in rodents using micro–computed tomography
Bouxsein, M., Boyd, S. K., Christiansen, B., Guldberg, R. E., Jepsen, K. J., & Müller, R. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.141 · Cited by 4,461 · see citing works
ON THE COMPARISON OF SEVERAL MEAN VALUES: AN ALTERNATIVE APPROACH
Welch, B. L. (1951) · Biometrika · doi:10.1093/biomet/38.3-4.330 · Cited by 1,531 · see citing works
Three rules for bone adaptation to mechanical stimuli
Turner, C. H. (1998) · Bone · doi:10.1016/s8756-3282(98)00118-5 · Cited by 971 · see citing works
Turner, R. T., Riggs, B. L., & Spelsberg, T. C. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-275 · Cited by 758 · see citing works
Self-citationTemporal relationship between bone loss and increased bone turnover in ovariectomized rats
Wronski, T. J., Cintrón, M., & Dann, L. M. (1988) · Calcified Tissue International · doi:10.1007/bf02571317 · Cited by 501 · see citing works
Inhibition of Bone Formation During Space Flight
Morey, E. R., & Baylink, D. J. (1978) · Science · doi:10.1126/science.150643 · Cited by 463 · see citing works
Skeletal alterations in ovariectomized rats
Wronski, T. J., Lowry, P. L., Walsh, C. C., & Ignaszewski, L. A. (1985) · Calcified Tissue International · doi:10.1007/bf02554882 · Cited by 381 · see citing works
Rittweger, J., Frost, H. M., Schießl, H., Ohshima, H., Alkner, B. A., Tesch, P. A., & Felsenberg, D. (2005) · Bone · doi:10.1016/j.bone.2004.11.014 · Cited by 351 · see citing works
The effects of ovariectomy and 17β-estradiol on cortical bone histomorphometry in growing rats
Turner, R. T., Vandersteenhoven, J. J., & Bell, N. H. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020206 · Cited by 347 · see citing works
Self-citationTime course of vertebral osteopenia in ovariectomized rats
Wronski, T. J., Dann, L. M., & Horner, S. L. (1989) · Bone · doi:10.1016/8756-3282(89)90067-7 · Cited by 260 · see citing works
Westerlind, K. C., Wronski, T. J., Ritman, E. L., Luo, Z.-P., An, K., Bell, N. H., & Turner, R. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4199 · Cited by 207 · see citing works
Self-citationBlaber, E. A., Dvorochkin, N., Lee, C., Alwood, J. S., Yousuf, R., Pianetta, P., Globus, R. K., Burns, B. P., & Almeida, E. A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061372 · Cited by 196 · see citing works
Differential effects of gonadal function on bone histomorphometry in male and female rats
Turner, R. T., Hannon, K. S., Demers, L. M., Buchanan, J. R., & Bell, N. H. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040415 · Cited by 193 · see citing works
Self-citationOrwoll, E. S., Adler, R. A., Amin, S., Binkley, N., Lewiecki, E. M., Petak, S. M., Shapses, S. A., Sinaki, M., Watts, N. B., & Sibonga, J. D. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1948 · Cited by 184 · see citing works
A new rat model simulating some aspects of space flight.
Morey, E. R., Sabelman, E. E., Turner, R. T., & Baylink, D. J. (1979) · PubMed · Cited by 165 · see citing works
Self-citationSpaceflight-induced Bone Loss: Is there an Osteoporosis Risk?
Sibonga, J. D. (2013) · Current Osteoporosis Reports · doi:10.1007/s11914-013-0136-5 · Cited by 147 · see citing works
Effect of spaceflight on periosteal bone formation in rats
Wronski, T. J., & Morey, E. R. (1983) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1983.244.3.r305 · Cited by 145 · see citing works
Invited Review: What do we know about the effects of spaceflight on bone?
Turner, R. T. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.2.840 · Cited by 120 · see citing works
Self-citationMeakin, L. B., Price, J. S., & Lanyon, L. E. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00154 · Cited by 117 · see citing works
Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus
Rubin, C. T., Gross, T. S., McLeod, K. J., & Bain, S. D. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100321 · Cited by 109 · see citing works
Cavolina, J. M., Evans, G. L., Harris, S. A., Zhang, M., Westerlind, K. C., & Turner, R. T. (1997) · Endocrinology · doi:10.1210/endo.138.4.5040 · Cited by 94 · see citing works
Self-citationTavella, S., Ruggiu, A., Giuliani, A., Brun, F., Canciani, B., Mănescu, A., Marozzi, K., Cilli, M., Costa, D., Liu, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033179 · Cited by 89 · see citing works
Westerlind, K. C., & Turner, R. T. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100603 · Cited by 88 · see citing works
Self-citationEffect of gender on bone turnover in adult rats during simulated weightlessness
Hefferan, T. E., Evans, G. L., Lotinun, S., Zhang, M., Morey, E. R., & Turner, R. T. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00455.2002 · Cited by 80 · see citing works
Self-citationLong-Duration Space Flight and Bed Rest Effects on Testosterone and Other Steroids
Smith, S. M., Heer, M. A., Wang, Z., Huntoon, C. L., & Zwart, S. R. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2233 · Cited by 76 · see citing works
Effects of Sex and Gender on Adaptations to Space: Reproductive Health
Ronca, A. E., Baker, E., Bavendam, T. G., Beck, K. D., Miller, V. M., Tash, J. S., & Jenkins, M. (2014) · Journal of Women s Health · doi:10.1089/jwh.2014.4915 · Cited by 75 · see citing works
Lafage‐Proust, M., Collet, P., Dubost, J. M., Laroche, N., Alexandre, C., & Vico, L. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r324 · Cited by 75 · see citing works
Effect of the High-Affinity Estrogen Receptor Ligand ICI 182,780 on the Rat Tibia
Sibonga, J. D., Dobnig, H., Harden, R., & Turner, R. T. (1998) · Endocrinology · doi:10.1210/endo.139.9.6172 · Cited by 74 · see citing works
Self-citationHistomorphometric analysis of rat skeleton following spaceflight
Wronski, T. J., Morey, E. R., Doty, S. B., Maese, A. C., & Walsh, C. C. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.252.2.r252 · Cited by 73 · see citing works
Histomorphometric analyses of cancellous bone from COSMOS 2044 rats
Vico, L., Bourrin, S., Genty, C., Palle, S., & Alexandre, C. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.5.2203 · Cited by 72 · see citing works
Backup, P., Westerlind, K. C., Harris, S. A., Spelsberg, T. C., Kline, B. C., & Turner, R. T. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.4.e567 · Cited by 70 · see citing works
Self-citationSpaceflight results in depressed cancellous bone formation in rat humeri.
Turner, R. T., Evans, G. L., & Wakley, G. K. (1995) · PubMed · Cited by 67 · see citing works
Self-citationTurner, R. T., Evans, G. L., Cavolina, J. M., Halloran, B. P., & Morey, E. R. (1998) · Endocrinology · doi:10.1210/endo.139.10.6227 · Cited by 63 · see citing works
Self-citationBagi, C. M., & Miller, S. C. (1994) · The Anatomical Record · doi:10.1002/ar.1092390303 · Cited by 62 · see citing works
Fragility and composition of growing rat bone after one week in spaceflight
Patterson‐Buckendahl, P., Arnaud, S. B., Mechanic, G. L., Martin, R. B., Grindeland, R. E., & Cann, C. E. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.252.2.r240 · Cited by 59 · see citing works
Effects of spaceflight on rat humerus geometry, biomechanics, and biochemistry
VAILAS, A. C., Zernicke, R. F., Grindeland, R. E., Kaplansky, A. S., Durnova, G. N., Li, K., & Martinez, D. A. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.1.2295378 · Cited by 57 · see citing works
Reversal of weightlessness-induced musculoskeletal losses with androgens: quantification by MRI
Wimalawansa, S. M., Chapa, M. T., Wei, J., Westlund, K. N., Quast, M. J., & Wimalawansa, S. J. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.6.1841 · Cited by 56 · see citing works
Wimalawansa, S. M., & Wimalawansa, S. J. (1999) · Endocrine · doi:10.1007/bf02738624 · Cited by 54 · see citing works
Effects of a 1-wk spaceflight on morphological and mechanical properties of growing bone
Shaw, S. R., VAILAS, A. C., Grindeland, R. E., & Zernicke, R. F. (1988) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1988.254.1.r78 · Cited by 53 · see citing works
Bateman, T. A., Zimmerman, R. J., Ayers, R. A., Ferguson, V. L., Chapes, S. K., & Simske, S. J. (1998) · Bone · doi:10.1016/s8756-3282(98)00135-5 · Cited by 50 · see citing works
Fifteen days of microgravity causes growth in calvaria of mice
Zhang, B., Cory, E., Bhattacharya, R., Sah, R. L., & Hargens, A. R. (2013) · Bone · doi:10.1016/j.bone.2013.06.009 · Cited by 46 · see citing works
Effects of diet and exposure to hindlimb suspension on estrous cycling in Sprague-Dawley rats
Tou, J. C. L., Grindeland, R. E., & Wade, C. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00287.2003 · Cited by 43 · see citing works
Mechanical loading modifies ovariectomy-induced cancellous bone loss
Lin, B. Y., Jee, W. S. S., Chen, M. M., Ma, Y. F., Ke, H. Z., & Li, X. J. (1994) · Bone and Mineral · doi:10.1016/s0169-6009(08)80239-5 · Cited by 38 · see citing works
Maturation of bone and dentin matrices in rats flown on the Soviet biosatellite Cosmos 1887
Simmons, D. J., Grynpas, M. D., & Rosenberg, G. D. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.1.2153084 · Cited by 37 · see citing works
Zérath, E., Godet, D., Holy, X., Andre, C., Renault, S., Hott, M., & Marie, P. J. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.164 · Cited by 36 · see citing works
Davis, B. A., Sipe, B. H., Gershan, L. A., Fiacco, G. J., Lorenz, T. C., Jeffrey, J. J., & Partridge, N. C. (1998) · Calcified Tissue International · doi:10.1007/s002239900550 · Cited by 28 · see citing works
Turner, R. T., & Iwaniec, U. T. (2011) · Bone · doi:10.1016/j.bone.2010.12.034 · Cited by 25 · see citing works
Self-citationCalcium metabolism and cardiovascular function after spaceflight
Hatton, D. C., Yue, Q., Dierickx, J., Roullet, C. M., Otsuka, K., Watanabe, M., Coste, S. C., Roullet, J. B., Phanouvang, T., ORWOLL, E. S., et al. (2002) · Journal of Applied Physiology · doi:10.1152/jappl.2002.92.1.3 · Cited by 23 · see citing works
Yarrow, J. F., McCoy, S. C., Ferreira, J. A., Pingel, J. E., Conrad, B. P., Wronski, T. J., Williams, A. A., Borst, S. E., & Brown, M. (2012) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318255657f · Cited by 16 · see citing works
Histology and histochemistry of intervertebral discs of rats participated in spaceflight.
Földes, I., Kern, M., Szilágyi, T., & Vs, O. (1996) · PubMed · Cited by 16 · see citing works
The pituitary-testicular axis in microgravity: analogies with the aging male syndrome.
Strollo, F., Boitani, C., Basciani, S., Pecorelli, L., Palumbo, D., Borgia, L., Masini, M. A., Morè, M., Strollo, G., Spera, G., et al. (2005) · PubMed · Cited by 10 · see citing works
The effects of spaceflight on mRNA levels for cytokines in proximal tibia of ovariectomized rats.
Zhang, M., & Rt, T. (1998) · PubMed · Cited by 8 · see citing works
Bullard, T. R., & Lindsay, H. A. (1968) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y68-103 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Morey E., Turner R. & Baylink D. The effect of spaceflight on selected bone parameters. (Neuka Press, 1979).
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Sorted by citations
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Vico, L., & Hargens, A. (2018) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2018.37 · Cited by 236 · see citing works
Influence of body weight on bone mass, architecture and turnover
Iwaniec, U. T., & Turner, R. T. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0089 · Cited by 199 · see citing works
Self-citationThe effects of microgravity on bone structure and function
Man, J., Graham, T., Squires-Donelly, G., & Laslett, A. L. (2022) · npj Microgravity · doi:10.1038/s41526-022-00194-8 · Cited by 160 · see citing works
Gerbaix, M., Gnyubkin, V., Farlay, D., Olivier, C., Ammann, P., Courbon, G., Laroche, N., Genthial, R., Follet, H., Peyrin, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03014-2 · Cited by 127 · see citing works
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Lee, S.-J., Lehar, A., Meir, J. U., Koch, C., Morgan, A., Warren, L. E., Rydzik, R., Youngstrom, D. W., Chandok, H., George, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014716117 · Cited by 115 · see citing works
“Interestingly, BMD in the humerus was not reduced in flight mice during this 22 d period, consistent with the differential effects of microgravity on the femur and humerus reported in rats (26) and humans (27).”
Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading
Tahimic, C. G. T., Paul, A. M., Schreurs, A., Torres, S. M., Rubinstein, L., Steczina, S., Lowe, M. G., Bhattacharya, S., Alwood, J. S., Ronca, A. E., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01147 · Cited by 58 · see citing works
Gerbaix, M., White, H., Courbon, G., Shenkman, B. S., Gauquelin‐Koch, G., & Vico, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00746 · Cited by 19 · see citing works
Reynolds, R. J., Scott, R. T., Turner, R. T., Iwaniec, U. T., Bouxsein, M., Sanders, L., & Antonsen, E. (2022) · Biomedicines · doi:10.3390/biomedicines10092187 · Cited by 18 · see citing works
Self-citationReptiles in Space Missions: Results and Perspectives
Gulimova, V. I., Proshchina, A. E., Kharlamova, A. S., Krivova, Y. S., Barabanov, V., Berdiev, R. K., Асадчиков, В. Е., Buzmakov, A. V., Zolotov, D. A., & Saveliev, S. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123019 · Cited by 18 · see citing works
Osumi, R., Wang, Z., Ishihara, Y., Odagaki, N., Iimura, T., & Kamioka, H. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01135-9 · Cited by 16 · see citing works
Microgravity Effects and Aging Physiology: Similar Changes or Common Mechanisms?
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Giuliani, A., Mazzoni, S., Ruggiu, A., Canciani, B., Cancedda, R., & Tavella, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00181 · Cited by 15 · see citing works
Zamarioli, A., Campbell, Z. R., Maupin, K. A., Childress, P., Ximenez, J. P. B., Adam, G., Chakraborty, N., Gautam, A., Hammamieh, R., & Kacena, M. A. (2021) · npj Microgravity · doi:10.1038/s41526-021-00140-0 · Cited by 15 · see citing works
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Moussa, M., Goldsmith, M., & Komarova, S. V. (2022) · JDR Clinical & Translational Research · doi:10.1177/23800844221084985 · Cited by 12 · see citing works
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Swinney, C. C., & Allison, Z. (2017) · World Neurosurgery · doi:10.1016/j.wneu.2017.10.062 · Cited by 9 · see citing works
Krivonosov, Y. S., Gulimova, V. I., Buzmakov, A. V., Zolotov, D. A., Cedola, A., Bukreeva, I., Асадчиков, В. Е., & Saveliev, S. V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752893 · Cited by 7 · see citing works
Cahill, R., Blaber, E. A., Juran, C. M., Cheng-Campbell, M., Alwood, J. S., Shirazi‐Fard, Y., & Almeida, E. A. C. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317307 · Cited by 6 · see citing works
Wong, C. P., Branscum, A. J., Fichter, A. R., Sargent, J., Iwaniec, U. T., & Turner, R. T. (2022) · Biochimie · doi:10.1016/j.biochi.2022.12.009 · Cited by 6 · see citing works
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Gamboa, A., Branscum, A. J., Olson, D. A., Sattgast, L. H., Iwaniec, U. T., & Turner, R. T. (2021) · Bone Reports · doi:10.1016/j.bonr.2021.100755 · Cited by 4 · see citing works
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Ma, Y. L., Burr, D. B., & Erben, R. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00082-8 · Cited by 4 · see citing works
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The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation
Wang, X., Zhang, H., Hu, L., He, J., Jiang, Q., Ren, L., Ke, Y., Fu, M., Li, Z., He, Z., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117172 · Cited by 2 · see citing works
Tereschenko, E. Y., Волков, В. В., Seregin, A. Y., Gulimova, V. I., & Savelyev, S. V. (2022) · Nanobiotechnology Reports · doi:10.1134/s2635167622030211 · Cited by 2 · see citing works
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- Authors
- Keune, J. A., Branscum, A. J., Iwaniec, U. T., & Turner, R. T.
- Affiliations
- Oregon State University (US)
- Corresponding author
- Turner, Russell T.
- Venue
- Scientific Reports
- Published
- 2015-12-22
- Volume
- 5
- Issue
- 1
- Pages
- 18671-18671
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4687043
- OpenAlex
- W2400856411
- Cited by
- 33
- References
- 55
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Aeronautics and Space Administration (NNX12AL24G)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- spaceflight, bone microarchitecture, ovariectomy, bone loss, trabecular bone, axial skeleton, appendicular skeleton, weight-bearing bones, lumbar vertebrae, calvarium, femur, humerus
- MeSH terms
- Animals, Bone and Bones, Female, Organ Size, Ovariectomy, Ovary, Rats, Inbred F344, Space Flight, Bone Density, Diaphyses, Growth and Development, X-Ray Microtomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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