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Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice

Watari, Kosuke, Shibata, Tomohiro, Nabeshima, Hiroshi, Shinoda, Ai, Fukunaga, Yuichi, Kawahara, Akihiko, Karasuyama, Kazuyuki, Fukushi, Jun-ichi, Iwamoto, Yukihide, Kuwano, Michihiko, Ono, Mayumi·2016·Scientific Reports
DOI 10.1038/srep19470PMC PMC4726041
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Abstract

N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot–Marie–Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodeling and inflammatory angiogenesis. Ndrg1 knockout (KO) mice exhibited abnormal curvature of the spine, high trabecular bone mass and reduced number of osteoclasts. We observed that serum levels of macrophage colony-stimulating factor (M-CSF) and macrophage-related cytokines were markedly decreased in KO mice. Differentiation of bone marrow (BM) cells into osteoclasts, M1/M2-type macrophages and dendritic cells was all impaired. Furthermore, KO mice also showed reduced tumor growth and angiogenesis by cancer cells, accompanied by decreased infiltration of tumor-associated macrophages. The transfer of BM-derived macrophages from KO mice into BM-eradicated wild type (WT) mice induced much less tumor angiogenesis than observed in WT mice. Angiogenesis in corneas in response to inflammatory stimuli was also suppressed with decreased infiltration of macrophages. Taken together, these results indicate that NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.

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Metadata

Authors
Watari, K., Shibata, T., Nabeshima, H., Shinoda, A., Fukunaga, Y., Kawahara, A., Karasuyama, K., Fukushi, J.-I., Iwamoto, Y., Kuwano, M., & Ono, M.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-01-18
Volume
6
Issue
1
ISSN
2045-2322
DOI
10.1038/srep19470
PMC
PMC4726041
Cited by
36
References
3
Language
en
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