Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

Bojarczuk, Aleksandra; Miller, Katie A.; Hotham, Richard; Lewis, Amy; Ogryzko, Nikolay V.; Kamuyango, Alfred A.; Frost, Helen; Gibson, Rory H.; Stillman, Eleanor; May, Robin C.; Renshaw, Stephen A.; Johnston, Simon A.

doi:10.1038/srep21489

Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients. Many questions remain regarding the function of macrophages in normal clearance of cryptococcal infection and the defects present in uncontrolled cryptococcosis. Two current limitations are: 1) The difficultie…