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Cited by 285

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions

Open access
Di Trapani, Mariano, Bassi, Giulio, Midolo, Martina, Gatti, Alessandro, Takam Kamga, Paul, Cassaro, Adriana, Carusone, Roberta, Adamo, Annalisa, Krampera, Mauro·2016·Scientific Reports
DOI 10.1038/srep24120
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Abstract

Mesenchymal stromal cells (MSCs) are multipotent cells, immunomodulatory stem cells that are currently used for regenerative medicine and treatment of a number of inflammatory diseases, thanks to their ability to significantly influence tissue microenvironments through the secretion of large variety of soluble factors. Recently, several groups have reported the presence of extracellular vesicles (EVs) within MSC secretoma, showing their beneficial effect in different animal models of disease. Here, we used a standardized methodological approach to dissect the immunomodulatory effects exerted by MSC-derived EVs on unfractionated peripheral blood mononuclear cells and purified T, B and NK cells. We describe here for the first time: i. direct correlation between the degree of EV-mediated immunosuppression and EV uptake by immune effector cells, a phenomenon further amplified following MSC priming with inflammatory cytokines; ii. induction in resting MSCs of immunosuppressive properties towards T cell proliferation through EVs obtained from primed MSCs, without any direct inhibitory effect towards T cell division. Our conclusion is that the use of reproducible and validated assays is not only useful to characterize the mechanisms of action of MSC-derived EVs, but is also capable of justifying EV potential use as alternative cell-free therapy for the treatment of human inflammatory diseases.

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Metadata

Authors
Di Trapani, M., Bassi, G., Midolo, M., Gatti, A., Takam Kamga, P., Cassaro, A., Carusone, R., Adamo, A., & Krampera, M.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-04-13
Volume
6
Issue
1
Pages
24120-24120
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep24120
OpenAlex
W2340631986
Cited by
285
References
61
FWCI
11.59
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions. https://app.cochat.ai/papers/10.1038/srep24120
The paper
Di Trapani, M., Bassi, G., Midolo, M., Gatti, A., Takam Kamga, P., Cassaro, A., Carusone, R., Adamo, A., & Krampera, M. (2016). Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions. Scientific Reports. https://doi.org/10.1038/srep24120

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