Interactions between mesenchymal stem cells and the immune system
Open accessAbstract
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess immunomodulatory functions that have been investigated as potential treatments in various immune disorders. MSCs can robustly interact with cells of the innate and adaptive immune systems, either through direct cell-cell contact or through their secretome. In this review, we discuss current findings regarding the interplay between MSCs and different immune cell subsets. We also draw attention to the mechanisms involved.
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In a model of endotoxin-induced lung injury, MSC-derived EVs inhibited the migration of neutrophils into the lung.
“in a model of endotoxin-induced lung injury, the MSC-derived-EVs inhibited the migration of neutrophils into the lung [42], [68]”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [42]
MSCs secrete CXCL8 and macrophage migration inhibitory factor, which recruit neutrophils into the injured site.
“MSCs also secrete CXCL8 (also known as IL-8) and macrophage migration inhibitory factor (MIF), known for recruiting neutrophils into the injured site [42], [64].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [42]
BM-MSCs can reduce apoptosis of resting or activated neutrophils by releasing IL-6, TSG-6 and SOD3.
“by releasing IL-6 [42], TSG-6 [62] and superoxide dismutase (SOD3) [63], BM-MSCs can reduce apoptosis of neutrophils that are resting or activated [42]”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [42]
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“[18, 19], with effective outcomes in several cases [41, 181–184].”
BackgroundMesenchymal stem cells induce apoptosis of activated T cells
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Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 205 · see citing works
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- Authors
- Li, N., & Hua, J.
- Affiliations
- Northwest A&F University (CN)
- Corresponding author
- Hua, Jinlian
- ORCID
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2017-02-18
- Volume
- 74
- Issue
- 13
- Pages
- 2345-2360
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11107583
- OpenAlex
- W2587794239
- Cited by
- 338
- References
- 13
- Citations by year
- 2026: 8 · 2025: 30 · 2024: 34 · 2023: 63 · 2022: 58 · 2021: 67 · 2020: 34 · 2019: 22 · 2018: 15 · 2017: 7
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the China National Basic Research Program (JFYS 2016YFA0100203)
- the National Natural Science Foundation of China (31272518, 31572399)
- the Program of the Shaanxi Province (2015NY157)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, immunomodulation, innate immune system, adaptive immunity, cell-cell contact, secretome, immune disorders, immune cell interactions
- MeSH terms
- Animals, Humans, Immune System, Models, Biological, Immunomodulation, Mesenchymal Stem Cells
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