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4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

Open access
Miao, Shida, Zhu, Wei, Castro, Nathan J., Nowicki, Margaret, Zhou, Xuan, Cui, Haitao, Fisher, John P., Zhang, Lijie Grace·2016·Scientific Reports

Abstract

Photocurable, biocompatible liquid resins are highly desired for 3D stereolithography based bioprinting. Here we solidified a novel renewable soybean oil epoxidized acrylate, using a 3D laser printing technique, into smart and highly biocompatible scaffolds capable of supporting growth of multipotent human bone marrow mesenchymal stem cells (hMSCs). Porous scaffolds were readily fabricated by simply adjusting the printer infill density; superficial structures of the polymerized soybean oil epoxidized acrylate were significantly affected by laser frequency and printing speed. Shape memory tests confirmed that the scaffold fixed a temporary shape at −18 °C and fully recovered its original shape at human body temperature (37 °C), which indicated the great potential for 4D printing applications. Cytotoxicity analysis proved that the printed scaffolds had significant higher hMSC adhesion and proliferation than traditional polyethylene glycol diacrylate (PEGDA) and had no statistical difference from poly lactic acid (PLA) and polycaprolactone (PCL). This research is believed to significantly advance the development of biomedical scaffolds with renewable plant oils and advanced 3D fabrication techniques.

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Metadata

Authors
Miao, S., Zhu, W., Castro, N. J., Nowicki, M., Zhou, X., Cui, H., Fisher, J. P., & Zhang, L. G.
Venue
Scientific Reports
Published
2016-06-02
Volume
6
Issue
1
Pages
27226-27226
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2410195985
Cited by
477
References
3
FWCI
14.13
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. https://app.cochat.ai/papers/10.1038/srep27226
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Miao, S., Zhu, W., Castro, N. J., Nowicki, M., Zhou, X., Cui, H., Fisher, J. P., & Zhang, L. G. (2016). 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. Scientific Reports. https://doi.org/10.1038/srep27226

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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