Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Osteoclast differentiation and activation

Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · see citing works

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works

Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025

Burge, R., Dawson-Hughes, B., Solomon, D. H., Wong, J. B., King, A., & Tosteson, A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061113 · Cited by 4,026 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Epidemiology and outcomes of osteoporotic fractures

Cummings, S. R., & Melton, L. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08657-9 · Cited by 3,821 · see citing works

Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis

Black, D. M., Delmas, P. D., Eastell, R., Reid, I. R., Boonen, S., Cauley, J. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067312 · Cited by 2,986 · see citing works

Reactive oxygen species in cell signaling

Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,936 · see citing works

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

Halliwell, B. B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92211-x · Cited by 2,926 · see citing works

Diagnosis of osteoporosis and assessment of fracture risk

Kanis, J. А. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08761-5 · Cited by 2,266 · see citing works

Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture

Lyles, K. W., Colón-Emeric, C. S., Magaziner, J. S., Adachi, J. D., Pieper, C. F., Mautalen, C., Hyldstrup, L., Recknor, C., Nordsletten, L., Moore, K. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa074941 · Cited by 2,003 · see citing works

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,213 · see citing works

Oxidative stress: the paradox of aerobic life

Davies, K. J. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610001 · Cited by 1,150 · see citing works

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

Maurer, U., Charvet, C., Wagman, A. S., Dejardin, E., & Green, D. R. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.009 · Cited by 881 · see citing works

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

Garrett, I. R., Boyce, B. F., Oreffo, R. O. C., Bonewald, L. F., Poser, J. W., & Mundy, G. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114485 · Cited by 807 · see citing works

Biochemical Markers of Bone Metabolism: An Overview

Christenson, R. H. (1997) · Clinical Biochemistry · doi:10.1016/s0009-9120(97)00113-6 · Cited by 544 · see citing works

Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic <i>ras</i> -Induced Premature Senescence

Wang, W., Chen, J. X., Liao, R., Deng, Q., Zhou, J. J., Huang, S., & Sun, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3389-3403.2002 · Cited by 376 · see citing works

Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI-298

Coxon, F. P., Helfrich, M., Hof, R. V., Sebti, S. M., Ralston, S. H., Hamilton, A. D., & Rogers, M. J. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.8.1467 · Cited by 361 · see citing works

Peculiarities of cell death mechanisms in neutrophils

Geering, B., & Simon, H.-U. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.75 · Cited by 301 · see citing works

Constitutive neutrophil apoptosis: Mechanisms and regulation

Luo, H. R., & Loison, F. (2007) · American Journal of Hematology · doi:10.1002/ajh.21078 · Cited by 300 · see citing works

Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

Benford, H. L., McGowan, N. W. A., Helfrich, M., NUTTALL, M. E., & Rogers, M. J. (2001) · Bone · doi:10.1016/s8756-3282(01)00412-4 · Cited by 235 · see citing works

Effects of Intravenous Zoledronic Acid Once Yearly on Bone Remodeling and Bone Structure

Recker, R. R., Delmas, P. D., Halse, J., Reid, I. R., Boonen, S., García-Hernández, P. A., Supronik, J., Lewiecki, E. M., Ochoa, L. A., Miller, P. D., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070906 · Cited by 224 · see citing works

Homocysteine Enhances Bone Resorption by Stimulation of Osteoclast Formation and Activity Through Increased Intracellular ROS Generation

Koh, J., Lee, Y., Kim, Y. S., Kim, D. J., Kim, H., Park, J., Lee, K., & Kim, G. S. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060406 · Cited by 202 · see citing works

Oncogenes in Cell Survival and Cell DeathPreprint

Shortt, J., & Johnstone, R. W. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009829 · Cited by 195 · see citing works

Efficacy of Bisphosphonates in Reducing Fracture Risk in Postmenopausal Osteoporosis

Bilezikian, J. P. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.12.003 · Cited by 166 · see citing works

ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation

Wang, X., Liu, J. Z., Hu, J. X., Wu, H., Li, Y. L., Chen, H. L., Bai, H., & Hai, C. X. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.019 · Cited by 146 · see citing works

Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

Chiu, W. C., Luo, S.-J., Chen, C., Cheng, J., Hsieh, C.-Y., Wang, C., Huang, W., Su, W., & Lin, C. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.016 · Cited by 103 · see citing works

Activation of p38 MAPK by Reactive Oxygen Species Is Essential in a Rat Model of Stress-Induced Gastric Mucosal Injury

Jia, Y., Wei, W., Ma, B., Xu, Y., Liu, W., Wang, Y., Lv, K., Tang, H., Wei, D., & Xia, Z. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7808 · Cited by 97 · see citing works

Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis

Huang, Q., Gao, B., Jie, Q., Wei, B.-Y., Fan, J., Zhang, H.-Y., Zhang, J., Li, X., Shi, J., Luo, Z., et al. (2014) · Bone · doi:10.1016/j.bone.2014.06.010 · Cited by 96 · see citing works

Osteoclast Apoptosis: The Role of Fasin Vivoandin Vitro

Wu, X., McKenna, M. A., Feng, X., Nagy, T. R., & McDonald, J. M. (2003) · Endocrinology · doi:10.1210/en.2003-0296 · Cited by 93 · see citing works

Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy

Shi, J., Wang, L., Zhang, H., Jie, Q., Li, X., Shi, Q., Huang, Q., Gao, B., Han, Y., Guo, K. X., et al. (2015) · Bone · doi:10.1016/j.bone.2015.06.014 · Cited by 90 · see citing works

Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species

Moon, H., Kim, S. E., Yun, Y.-P., Hwang, Y., Bang, J. B., Park, J.-H., & Kwon, I. K. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.11.067 · Cited by 89 · see citing works

Glycogen Synthase Kinase-3β Facilitates IFN-γ-Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2

Tsai, C., Kai, J.-I., Huang, W., Wang, C., Wang, Y., Chen, C., Fang, Y.-T., Lin, Y.-S., Anderson, R., Chen, S., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804033 · Cited by 81 · see citing works

Active caspase‐3 is required for osteoclast differentiation

Szymczyk, K. H., Freeman, T., Adams, C. S., Srinivas, V., & Steinbeck, M. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20770 · Cited by 80 · see citing works

Genistein Inhibits Osteoclastic Differentiation of RAW 264.7 Cells via Regulation of ROS Production and Scavenging

Lee, S., Kim, J., & Jang, H. D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150610605 · Cited by 80 · see citing works

Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence

Rabenda, V., Hiligsmann, M., & Reginster, J. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903140533 · Cited by 78 · see citing works

Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-κB

Kyung, T.-W., Lee, J.-E., Shin, H., & Choi, H.-S. (2008) · Experimental and Molecular Medicine · doi:10.3858/emm.2008.40.1.52 · Cited by 67 · see citing works

MCL-1 Inhibits BAX in the Absence of MCL-1/BAX Interaction

Germain, M., Milburn, J., & Duronio, V. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707762200 · Cited by 64 · see citing works

Once-yearly zoledronic acid in the prevention of osteoporotic bone fractures in postmenopausal women

Lambrinoudaki, I. V. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s2046 · Cited by 62 · see citing works

Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts

Faust, D., Schmitt, C. R., Oesch, F., Oesch‐Bartlomowicz, B., Schreck, I., Weiß, C., & Dietrich, C. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-6 · Cited by 62 · see citing works

NADPH Oxidases in Redox Regulation of Cell Adhesion and Migration

Schröder, K. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5633 · Cited by 60 · see citing works

Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways

Bruzzese, F., Pucci, B., Milone, M. R., Ciardiello, C., Franco, R., Chianese, M. I., Rocco, M., Gennaro, E. D., Leone, A., Luciano, A., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.406 · Cited by 58 · see citing works

Anti–Dengue Virus Nonstructural Protein 1 Antibodies Cause NO-Mediated Endothelial Cell Apoptosis via Ceramide-Regulated Glycogen Synthase Kinase-3β and NF-κB Activation

Chen, C., Lin, C., Wan, S.-W., Wei, L.-S., Chen, M.-C., Yeh, T., Liu, H., Anderson, R., & Lin, Y.-S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201976 · Cited by 49 · see citing works

Reactive oxygen species on bone mineral density and mechanics in Cu,Zn superoxide dismutase (Sod1) knockout mice

Smietana, M. J., Arruda, E. M., Faulkner, J. A., Brooks, S. V., & Larkin, L. M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.006 · Cited by 49 · see citing works

Negative Feedback Loop in the Bim–Caspase-3 Axis Regulating Apoptosis and Activity of Osteoclasts

Wakeyama, H., Akiyama, T., Takahashi, K., Amano, H., Kadono, Y., Nakamura, M., Oshima, Y., Itabe, H., Nakayama, K., Nakayama, K., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070619 · Cited by 46 · see citing works

Anesthetic Propofol Causes Glycogen Synthase Kinase-3β-regulated Lysosomal/Mitochondrial Apoptosis in Macrophages

Hsing, C., Chen, Y., Chen, C., Huang, W., Lin, M.-C., Tseng, P., Wang, C., Tsai, C., Choi, P.-C., & Lin, C. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31824af68a · Cited by 38 · see citing works

Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors

Tai, T., Su, F., Chen, C., Jou, I., & Lin, C. (2014) · Bone · doi:10.1016/j.bone.2014.07.003 · Cited by 37 · see citing works

Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis

Oursler, M. J., Bradley, E. W., Elfering, S. L., & Giulivi, C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00092.2004 · Cited by 37 · see citing works

Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

Ge, X., Yang, L., Jiang, Y. Z., Yang, W., Fu, J., & Li, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101207 · Cited by 36 · see citing works

NADPH oxidase activity: In the crossroad of neutrophil life and death

Arruda, M. A. (2009) · Frontiers in bioscience · doi:10.2741/3547 · Cited by 35 · see citing works

Reactive oxygen species-regulated glycogen synthase kinase-3β activation contributes to all-trans retinoic acid-induced apoptosis in granulocyte-differentiated HL60 cells

Wang, C., Yang, T.-T., Chen, C., Lin, W., & Lin, C. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.021 · Cited by 32 · see citing works

Caspase-2 Maintains Bone Homeostasis by Inducing Apoptosis of Oxidatively-Damaged Osteoclasts

Sharma, R., Callaway, D. A., Vanegas, D., Bendele, M., Lopez‐Cruzan, M., Horn, D., Guda, T., Fajardo, R. J., Abboud‐Werner, S. L., & Herman, B. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093696 · Cited by 31 · see citing works

Nitric oxide-mediated cytotoxic effect induced by zoledronic acid treatment on human gingival fibroblasts

COLLI, M. D., Zara, S., di Giacomo, V., Patruno, A., Marconi, G. D., Gallorini, M., Zizzari, V. L., Tetè, G., & Cataldi, A. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1344-9 · Cited by 21 · see citing works

Zoledronic acid significantly enhances radiation-induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling

Koto, K., Murata, H., Kimura, S. H., SAWAI, Y., Horie, N., Matsui, T., Ryu, K., Ashihara, E., Maekawa, T., Kubo, T., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1735 · Cited by 13 · see citing works

Targeting NOX4 knocks down osteoporosis

Harrison, C. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4182 · Cited by 12 · see citing works

Risedronate's efficacy: from randomized clinical trials to real clinical practice.

Iolascon, G., Sirico, F., Ferrante, A., Gimigliano, R., & Gimigliano, F. (2010) · PubMed Central · Cited by 7 · see citing works

High levels of ROS block the differentiation of human and mouse osteoclasts (100.5)

Moreno, J. L., Celluzzi, C. M., Keegan, A. D., & Williams, M. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.supp.100.5 · Cited by 1 · see citing works

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Agidigbi, T. S., & Kim, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143576 · Cited by 518 · see citing works

Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts

Kim, H., Lee, K., Kim, J., Kim, M. Y., Kim, J.-R., Lee, H., Chung, Y. W., Shin, H.-I., Kim, T. S., Park, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22565-7 · Cited by 83 · see citing works

ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review

Huang, W., Gong, Y., & Yan, L. W. (2023) · Biomolecules · doi:10.3390/biom13071050 · Cited by 65 · see citing works

Photocatalytic Oxygenation and Deoxygenation Transformations over BCN Nanosheets

Zheng, M., Tao, Y., Shi, J., Cai, W., & Wang, X. (2019) · ACS Catalysis · doi:10.1021/acscatal.9b02550 · Cited by 62 · see citing works

Regulation of osteogenesis and osteoclastogenesis by zoledronic acid loaded on biodegradable magnesium-strontium alloy

Li, M., Wan, P., Wang, W., Yang, K., Zhang, Y., & Han, Y. N. (2019) · Scientific Reports · doi:10.1038/s41598-018-37091-8 · Cited by 56 · see citing works

M2 macrophages secrete glutamate-containing extracellular vesicles to alleviate osteoporosis by reshaping osteoclast precursor fate

Huang, X., Lan, Y., Shen, J., Zhao, X., Zhou, Y., Wu, W., Mao, J., Wu, Y., Xie, Z., & Chen, Z. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.005 · Cited by 56 · see citing works

How zoledronic acid improves osteoporosis by acting on osteoclasts

Wang, B., Zhan, Y., Yan, L. W., & Hao, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.961941 · Cited by 52 · see citing works

A Dual-Targeted Metal–Organic Framework Based Nanoplatform for the Treatment of Rheumatoid Arthritis by Restoring the Macrophage Niche

Tao, S., Yu, H., You, T., Kong, X., Wei, X., Zheng, Z., Zheng, L., Feng, Z., Huang, B. H., Zhang, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03828 · Cited by 52 · see citing works

Dose-Dependent Effects of Zoledronic Acid on Human Periodontal Ligament Stem Cells: An In Vitro Pilot Study

Vito, A. D., Chiarella, E., Baudi, F., Scardamaglia, P., Antonelli, A., Giudice, D., Barni, T., Fortunato, L., & Giudice, A. (2020) · Cell Transplantation · doi:10.1177/0963689720948497 · Cited by 49 · see citing works

Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways

Huang, X., Huang, L., Cheng, Y., Li, F., Zhou, Q., Wu, C., Shi, Q., Guan, Z., Liao, J., & Hong, W. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4207 · Cited by 49 · see citing works

Bisphosphonate‐induced reactive oxygen species inhibit proliferation and migration of oral fibroblasts: A pathogenesis of bisphosphonate‐related osteonecrosis of the jaw

Taniguchi, N., Osaki, M., Onuma, K., Ishikawa, M., Ryoke, K., Kodani, I., & Okada, F. (2019) · Journal of Periodontology · doi:10.1002/jper.19-0385 · Cited by 46 · see citing works

Tea polysaccharide inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells and ameliorates ovariectomy-induced osteoporosis in rats

Xu, H., Yin, D., Liu, T., Chen, F., Chen, Y., Wang, X., & Sheng, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.125 · Cited by 44 · see citing works

A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties

Zhang, Y., Huo, M., Wang, Y., Xiao, L., Wu, J., Ma, Y., Zhang, D., Lang, X., & Wang, X. (2022) · Journal of Biological Engineering · doi:10.1186/s13036-022-00301-z · Cited by 43 · see citing works

Nitrogen-Containing Bisphosphonates Are Associated With Reduced Risk of Pneumonia in Patients With Hip Fracture

Sing, C., Kiel, D. P., Hubbard, R., Lau, W. C. Y., Li, G. H., Kung, A. W. C., Wong, I. C. K., & Cheung, C. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4030 · Cited by 39 · see citing works

A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint

Singh, V., Naldi, A., Soliman, S., & Niarakis, A. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00294-5 · Cited by 28 · see citing works

Ophiopogonin D improves osteointegration of titanium alloy implants under diabetic conditions by inhibition of ROS overproduction via Wnt/β-catenin signaling pathway

Ma, X., Wen, X., Yang, X., Zhou, D., Wu, Q., Feng, Y., Ding, H.-J., Lei, W., Yu, H., Liu, B., et al. (2018) · Biochimie · doi:10.1016/j.biochi.2018.04.022 · Cited by 27 · see citing works

Spectrophotometric and visual determination of zoledronic acid by using a bacterial cell-derived nanopaper doped with curcumin

Faham, S., Ghavami, R., Golmohammadi, H., & Khayatian, G. (2019) · Microchimica Acta · doi:10.1007/s00604-019-3815-9 · Cited by 22 · see citing works

Black Rice (Oryza sativaL.) Fermented withLactobacillus caseiAttenuates Osteoclastogenesis and Ovariectomy-Induced Osteoporosis

Lee, Y. M., Kim, I. S., & Lim, B. O. (2019) · BioMed Research International · doi:10.1155/2019/5073085 · Cited by 19 · see citing works

Zoledronic Acid-Loaded β-TCP Inhibits Tumor Proliferation and Osteoclast Activation: Development of a Functional Bone Substitute for an Efficient Osteosarcoma Treatment

Kameda, Y., Aizawa, M., Sato, T., & Honda, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041889 · Cited by 18 · see citing works

Zoledronic acid modulates osteoclast apoptosis through activation of the NF-κB signaling pathway in ovariectomized rats

Cheng, Y., Liao, J., Zhou, Q., Huo, H., Zellmer, L., Tang, Z., Ma, H., Hong, W., & Liao, D. J. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211011052 · Cited by 17 · see citing works

Cedrol, a Ginger-derived sesquiterpineol, suppresses estrogen-deficient osteoporosis by intervening NFATc1 and reactive oxygen species

Xu, C., Jin, S., Jin, S., Dai, Z.-H., Wu, Y., He, G.-L., Ma, H., Xu, C.-Y., & Fang, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109893 · Cited by 15 · see citing works

Glucagon‐like peptide 2 decreases osteoclasts by stimulating apoptosis dependent on nitric oxide synthase

Lu, Y., Lu, D., & Hu, Y. (2018) · Cell Proliferation · doi:10.1111/cpr.12443 · Cited by 12 · see citing works

The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation

Wang, L., Gao, H., Xiao-ya, Y., Liang, X., Tan, Q., Chen, Z., Zhao, C., Gu, Z., Yu, M., Zheng, Y., et al. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12979 · Cited by 11 · see citing works

Development of an In Vitro 3D Model for Investigating Ligamentum Flavum Hypertrophy

Lin, C., Kuo, Y.-T., Tsao, C.-H., Shyong, Y., Shih, S.-H., & Tu, T. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00132-6 · Cited by 11 · see citing works

Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase

Liu, D., Du, J., Sun, J. Y., & Li, M. (2021) · Bioengineered · doi:10.1080/21655979.2021.1928930 · Cited by 10 · see citing works

Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats

Yoshioka, Y., Yamachika, E., Nakanishi, M., Ninomiya, T., Nakatsuji, K., Kobayashi, Y., Fujii, T., & Iida, S. (2018) · British Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.bjoms.2018.08.003 · Cited by 9 · see citing works

Streptolysin O derived from Streptococcus�pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway

Jin, Y., Tang, R., Yang, J., Chen, Y., & Fei, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9662 · Cited by 9 · see citing works

Zoledronic acid modulates human osteosarcoma cells proliferation via GSK-3β activation

Li, S., & Li, J. J. (2019) · Neoplasma · doi:10.4149/neo_2018_181128n904 · Cited by 9 · see citing works

Medication-related osteonecrosis of the jaw (MRONJ) systemic review: mevalonate pathway mechanisms explored

Cho, J., Feldman, G. J., Tomlinson, R. E., Taub, D. I., & Diecidue, R. J. (2024) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2024.05.014 · Cited by 8 · see citing works

Bisphosphonate type-dependent cell viability suppressive effects of carbon nanohorn–calcium phosphate–bisphosphonate nanocomposites

Nakamura, M., Ueda, K., Yamamoto, Y., Aoki, K., Zhang, M., Saito, N., & Yudasaka, M. (2022) · Biomaterials Science · doi:10.1039/d2bm00822j · Cited by 6 · see citing works

AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption

Sun, J., Cai, G., Shen, J., Cheng, P., Zhang, J., Jiang, D., Xu, X., Lu, F., Chen, L., & Chen, H. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s403231 · Cited by 5 · see citing works

Zoledronic Acid Accelerates Bone Healing in Carpal Navicular Fracture via Silencing Long Non-coding RNA Growth Arrest Specificity 5 to Modulate MicroRNA-29a-3p Expression

Liu, X., Tian, L., Deng, Z., Guo, Y., & Zhang, S. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00931-8 · Cited by 4 · see citing works

Bisphosphonates loaded nanoparticles in microparticles: a potential macrophage targeting and repolarizing drug delivery system

Sagoe, P. N. K., Zink, B., & Jain, E. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01889-7 · Cited by 4 · see citing works

Prophylactic supplementation of sinapic acid ameliorates zoledronic acid induced changes in osteoblast survival and differentiation

Sadhasivam, D. R., Soundararajan, S., Elumalai, S., Karuppiah, P., & Al-Dhabi, N. A. (2020) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2020.101700 · Cited by 3 · see citing works

Inhibition of osteoclastogenesis after bisphosphonate therapy discontinuation: an in vitro approach

Bradaschia-Corrêa, V., Ribeiro-Santos, G., de Faria, L. P., Teixeira, P. R., & Arana-Chavez, V. E. (2022) · Journal of Molecular Histology · doi:10.1007/s10735-022-10083-9 · Cited by 3 · see citing works

Brain-Type Creatine Kinase Release from Cultured Osteoclasts Exposed to Neridronate in Children Affected by Osteogenesis Imperfecta Type 1

Faienza, M. F., Tummolo, A., Celli, M., Finocchiaro, R., Piacente, L., Serio, F. D., Nicchia, G. P., Brunetti, G., & D’Eufemia, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020458 · Cited by 3 · see citing works

Role of Reactive Oxygen Species in the Cytotoxicity of Arsenic Trioxide and Pamidronate for Human Prostate Cancer Cells

Doroshow, J. H., & Gaur, S. (2020) · doi:10.20455/ros.2020.811 · Cited by 3 · see citing works

Osteoblastic cell responses to zoledronate treatment in-vitro: A systematic review

Florez-Martin, M., Radu, A.-M., Shakib, K., & Jell, G. (2026) · Bone · doi:10.1016/j.bone.2026.117796 · Cited by 2 · see citing works

Identification of hub genes and therapeutic drugs in osteonecrosis of the femoral head through integrated bioinformatics analysis and literature mining

Tang, L. F., Li, B., Su, Q., Chen, X., & He, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-39258-4 · Cited by 2 · see citing works

Comprehensive evaluation of compound Kushen injection combined with zoledronic acid in treating bone metastasis cancer pain based on meta-analysis and decision tree model

Zhao, X., Meng, T., Wang, K., Yan, X., Liu, Y., & Li, X. (2025) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1512925 · Cited by 2 · see citing works

Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption

Gai, D., Caviness, P. C., Lazarenko, O. P., Chen, J. F., Randolph, C. E., Zhang, Z., Cheng, Y., Sun, F., Xu, H., Blackburn, M. L., et al. (2025) · Cancers · doi:10.3390/cancers17050833 · Cited by 1 · see citing works

[Risedronate inhibits rat bone marrow adipogenesis and reduces RANKL expression in adipocytes].

Jin, J., & Jin, D. (2019) · Europe PMC (PubMed Central) · doi:10.12122/j.issn.1673-4254.2019.08.17 · Cited by 1 · see citing works

Molecular docking of the active compound Garcinia mangostana on the RANKL/RANK/OPG system

Setiawan, B., Suhartono, E., Kaidah, S., Akbar, I. Z., & Noor, Z. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1374/1/012054 · Cited by 1 · see citing works

Gradual repression of selenoprotein W ensures physiological bone remodellingPreprint

Kim, H., Lee, K. H., Kim, J., Kim, J.-R., Lee, H., Chung, Y. W., Shin, H., Park, E., Rho, J., Lee, S. H., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/254433 · Cited by 1 · see citing works

Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influxPreprint

Chen, J., Gai, D., Caviness, P. C., Lazarenko, O. P., Chen, J., Randolph, C., Zhang, Z., Cheng, Y., Sun, F., Xu, H., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4313179/v1 · Cited by 1 · see citing works

Evaluation of Non-Surgical Periodontal Treatment on Salivary Biomarkers in Patients Undergoing Bisphosphonate Therapy

Karasu, B., Özcan, G., İşler, S. Ç., Akca, G., Kaymaz, Ö., & Bozkurt, S. (2025) · Cumhuriyet Dental Journal · doi:10.7126/cumudj.1411790

Additional file 1 of Development of an In Vitro 3D Model for Investigating Ligamentum Flavum Hypertrophy

Lin, C.-L., Kuo, Y.-T., Tsao, C.-H., Shyong, Y.-J., Shih, S.-H., & Tu, T.-Y. (2020) · Figshare · doi:10.6084/m9.figshare.12900464

CCAR2 reduces the number of osteoclasts by controlling osteoclast apoptosis

Zhang, J., Song, Y., Chen, S., Jang, K. Y., Kim, J. R., & Moon, Y. J. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2026052

The role of the AMPK/NLRP3 axis in osteoarthritic bone marrow lesions of the knee: from molecular mechanisms to clinical applications

Zhou, J., Su, H., Zhang, H., Dong, J., & Xiao, H. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-026-10811-5 · Cited by 1 · see citing works

Mechanism-Oriented Biomaterial Strategies for Bone Regeneration in BRONJ: From Pathological Barriers to Evidence-Matched Repair

Jiang, A., Liao, J., Shi, Y., Song, W., Luo, S., Li, L., & Zhang, Z. (2026) · Biomolecules · doi:10.3390/biom16091259

Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors

Tai, T., Su, F., Chen, C., Jou, I., & Lin, C. (2014) · Bone · doi:10.1016/j.bone.2014.07.003 · Cited by 37 · see citing works

Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis

Evdokiou, A., Labrinidis, A., Bouralexis, S., Hay, S. J., & Findlay, D. M. (2003) · Bone · doi:10.1016/s8756-3282(03)00223-0 · Cited by 73 · see citing works

Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis

Sudhoff, H. H., Faddis, B. T., Jung, J. Y., Hildmann, H., Ebmeyer, J., & Chole, R. A. (2003) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940311200907 · Cited by 22 · see citing works

Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis

来海, 慶., Kajiya, H., Nakayama, S., Ikebe, T., & Okabe, K. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0596-4 · Cited by 84 · see citing works

Zoledronic acid at subtoxic dose extends osteoblastic stage span of primary human osteoblasts

Zara, S., COLLI, M. D., di Giacomo, V., Zizzari, V. L., Nisio, C. D., Tore, U. D., Salini, V., Gallorini, M., Tetè, S., & Cataldi, A. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1280-8 · Cited by 26 · see citing works