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Cited by 197Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Organization of prefrontal network activity by respiration-related oscillations

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Biskamp, Jonatan, Bartos, Marlene, Sauer, Jonas-Frederic·2017·Scientific Reports
DOI 10.1038/srep45508PMC PMC5368652
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Abstract

The medial prefrontal cortex (mPFC) integrates information from cortical and sub-cortical areas and contributes to the planning and initiation of behaviour. A potential mechanism for signal integration in the mPFC lies in the synchronization of neuronal discharges by theta (6–12 Hz) activity patterns. Here we show, using in vivo local field potential (LFP) and single-unit recordings from awake mice, that prominent oscillations in the sub-theta frequency band (1–5 Hz) emerge during awake immobility in the mPFC. These oscillation patterns are distinct from but phase-locked to hippocampal theta activity and occur synchronized with nasal respiration (hence termed prefrontal respiration rhythm [PRR]). PRR activity modulates the amplitude of prefrontal gamma rhythms with greater efficacy than theta oscillations. Furthermore, single-unit discharges of putative pyramidal cells and GABAergic interneurons are entrained by prefrontal PRR and nasal respiration. Our data thus suggest that PRR activity contributes to information processing in the prefrontal neuronal network.

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  • Respiration also modulates neural activity in medial prefrontal cortex in rodents.

    “Respiration also modulates neural activity in medial prefrontal cortex in rodents 130,133-135 ,”

    From Interoceptive rhythms in the brain (2023) · cites this paper as [133]

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Cited by

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Authors
Biskamp, J., Bartos, M., & Sauer, J.-F.
Affiliations
University of Freiburg (DE)
Corresponding author
  • Bartos, Marlene
  • Sauer, Jonas-Frederic
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-03-28
Volume
7
Issue
1
Pages
45508-45508
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep45508
PMC
PMC5368652
OpenAlex
W2602656046
Cited by
197
References
5
Citations by year
2026: 9 · 2025: 17 · 2024: 18 · 2023: 31 · 2022: 32 · 2021: 36 · 2020: 12 · 2019: 15 · 2018: 20 · 2017: 7
FWCI
8.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (FOR2143, EXC‐1086)
  • Volkswagen Foundation
  • Albert-Ludwigs-Universität Freiburg (EXC 1086)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
medial prefrontal cortex, nasal breathing, theta oscillations, gamma oscillations, neuronal synchronization, GABAergic interneurons, pyramidal neurons, local field potentials, single-unit activity, information integration, mice
MeSH terms
Animals, Hippocampus, Nerve Net, Respiration, Theta Rhythm, Wakefulness, Prefrontal Cortex, Mice

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