A 4 Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activities
Open accessAbstract
Network oscillations support transient communication across brain structures. We show here, in rats, that task-related neuronal activity in the medial prefrontal cortex (PFC), the hippocampus, and the ventral tegmental area (VTA), regions critical for working memory, is coordinated by a 4 Hz oscillation. A prominent increase of power and coherence of the 4 Hz oscillation in the PFC and the VTA and its phase modulation of gamma power in both structures was present in the working memory part of the task. Subsets of both PFC and hippocampal neurons predicted the turn choices of the rat. The goal-predicting PFC pyramidal neurons were more strongly phase locked to both 4 Hz and hippocampal theta oscillations than nonpredicting cells. The 4 Hz and theta oscillations were phase coupled and jointly modulated both gamma waves and neuronal spikes in the PFC, the VTA, and the hippocampus. Thus, multiplexed timing mechanisms in the PFC-VTA-hippocampus axis may support processing of information, including working memory.
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An oscillation varying between 2-5 Hz could also be involved in PFC-hippocampus coupling.
“an oscillation varying between 2–5 Hz could also be involved in the PFC-hippocampus coupling”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Fujisawa and Buzsaki, 2011
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- Authors
- Fujisawa, S., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Buzsáki, György
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 72
- Issue
- 1
- Pages
- 153-165
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3235795
- OpenAlex
- W1988220777
- Cited by
- 501
- References
- 63
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 36 · 2023: 28 · 2022: 23 · 2021: 37 · 2020: 31 · 2019: 42 · 2018: 51 · 2017: 41 · 2016: 40 · 2015: 28 · 2014: 33 · 2013: 43 · 2012: 26
- FWCI
- 16.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 691 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- working memory, medial prefrontal cortex, ventral tegmental area, hippocampus, theta oscillations, gamma oscillations, phase synchronization, phase locking, goal prediction
- MeSH terms
- Action Potentials, Animals, Choice Behavior, Hippocampus, Male, Memory, Short-Term, Neurons, Prefrontal Cortex, Ventral Tegmental Area, Rats, Brain Waves
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