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Cited by 379

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

Open access
de Mello, Vanessa D., Paananen, Jussi, Lindström, Jaana, Lankinen, Maria A., Shi, Lin, Kuusisto, Johanna, Pihlajamäki, Jussi, Auriola, Seppo, Lehtonen, Marko, Rolandsson, Olov, Bergdahl, Ingvar A., Nordin, Elise, Ilanne-Parikka, Pirjo, Keinänen-Kiukaanniemi, Sirkka, Landberg, Rikard, Eriksson, Johan G., Tuomilehto, Jaakko, Hanhineva, Kati, Uusitupa, Matti·2017·Scientific Reports
DOI 10.1038/srep46337
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Abstract

Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.

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Metadata

Authors
de Mello, V. D., Paananen, J., Lindström, J., Lankinen, M. A., Shi, L., Kuusisto, J., Pihlajamäki, J., Auriola, S., Lehtonen, M., Rolandsson, O., Bergdahl, I. A., Nordin, E., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Landberg, R., Eriksson, J. G., Tuomilehto, J., Hanhineva, K., & Uusitupa, M.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-04-11
Volume
7
Issue
1
Pages
46337-46337
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep46337
OpenAlex
W2606493877
Cited by
379
References
17
FWCI
8.54
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. https://app.cochat.ai/papers/10.1038/srep46337
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de Mello, V. D., Paananen, J., Lindström, J., Lankinen, M. A., Shi, L., Kuusisto, J., Pihlajamäki, J., Auriola, S., Lehtonen, M., Rolandsson, O., Bergdahl, I. A., Nordin, E., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Landberg, R., Eriksson, J. G., Tuomilehto, J., Hanhineva, K., & Uusitupa, M. (2017). Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports. https://doi.org/10.1038/srep46337

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.