Microbial regulation of organismal energy homeostasis

Cani, Patrice D.; Van Hul, Matthias; Lefort, Charlotte; Depommier, Clara; Rastelli, Marialetizia; Everard, Amandine

doi:10.1038/s42255-018-0017-4

Cited by 602Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesAnimal Nutrition and Physiology

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Microbial regulation of organismal energy homeostasis

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Cani, Patrice D., Van Hul, Matthias, Lefort, Charlotte, Depommier, Clara, Rastelli, Marialetizia, Everard, Amandine·2019·Nature Metabolism

DOI 10.1038/s42255-018-0017-4

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Abstract

The gut microbiome has emerged as a key regulator of host metabolism. Here we review the various mechanisms through which the gut microbiome influences the energy metabolism of its host, highlighting the complex interactions between gut microbes, their metabolites and host cells. Among the most important bacterial metabolites are short-chain fatty acids, which serve as a direct energy source for host cells, stimulate the production of gut hormones and act in the brain to regulate food intake. Other microbial metabolites affect systemic energy expenditure by influencing thermogenesis and adipose tissue browning. Both direct and indirect mechanisms of action are known for specific metabolites, such as bile acids, branched chain amino acids, indole propionic acid and endocannabinoids. We also discuss the roles of specific bacteria in the production of specific metabolites and explore how external factors, such as antibiotics and exercise, affect the microbiome and thereby energy homeostasis. Collectively, we present a large body of evidence supporting the concept that gut microbiota-based therapies can be used to modulate host metabolism, and we expect to see such approaches moving from bench to bedside in the near future.

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Gut microbiota regulates whole‐body energy homeostasis in response to cold, nutrition, or fasting/feeding cycles through the production of SCFAs and secondary BAs.
“Furthermore, gut microbiota has been described in the past two decades as a very important player in the regulation of whole‐body energy homeostasis, in response to diverse stimuli such as cold 165, 166, nutrition 167, 168, or fasting/feeding cycles 168, 169, 170, through the production of mediators such as short chain fatty acids (SCFAs) and secondary BAs 167, 169.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [169]

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Authors: Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A.
Affiliations: Walloon Excellence in Lifesciences and Biotechnology (BE)
Corresponding author: Cani, Patrice D.
ORCID: Cani, Patrice D.
Lefort, Charlotte
Depommier, Clara
Rastelli, Marialetizia
Everard, Amandine
Venue: Nature Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2019-01-07
Volume: 1
Issue: 1
Pages: 34-46
ISSN: 2522-5812 (ISSN-L)
DOI: 10.1038/s42255-018-0017-4
OpenAlex: W2907048060
Cited by: 569
References: 210
Citations by year: 2026: 55 · 2025: 68 · 2024: 88 · 2023: 79 · 2022: 100 · 2021: 94 · 2020: 54 · 2019: 31
FWCI: 4.39
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Metabolism (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: gut microbiota, energy homeostasis, host metabolism, short-chain fatty acids, gastrointestinal hormones, food intake regulation, thermogenesis, brown adipose tissue, bile acids, branched-chain amino acids, endocannabinoids, antibiotics, physical activity, microbiota-based therapy, metabolic disorders
MeSH terms: Gastrointestinal Microbiome, Animals, Energy Metabolism, Fatty Acids, Volatile, Homeostasis, Humans, Organ Specificity, Biomarkers, Biodiversity, Host-Pathogen Interactions, Microbiota

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Microbial regulation of organismal energy homeostasis

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