The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Open accessAbstract
Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In vivo studies examining the impacts of microplastics in mammals have also shown effects at high exposure concentrations, including changes in energy and lipid metabolism and oxidative stress (polystyrene particles 5μm in diameter at a concentration of 1.46×106 particles/0.5mL and 20μm in diameter at a concentration of 2.27×104 particles/0.5mL)30”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Although some in vitro and in vivo studies examining impacts of microplastics on mammals show effects, such as intestinal barrier disfunction and alteration of biomarkers,30,31”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, it is unclear if toxicological effects from either of these mechanisms are occurring in humans, and at what thresholds effects occur.”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Microplastics in the marine environment
Andrady, A. L. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.05.030 · Cited by 8,105
Microplastic ingestion by zooplankton
Cole, M., Lindeque, P., Fileman, E., Halsband, C., Goodhead, R., Moger, J., & Galloway, T. S. (2013) · Environmental Science & Technology · doi:10.1021/es400663f · Cited by 2,763
Eerkes-Medrano, D., Thompson, R. C., & Aldridge, D. C. (2015) · Water Research · doi:10.1016/j.watres.2015.02.012 · Cited by 2,638
Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M., & Thompson, R. C. (2008) · Environmental Science & Technology · doi:10.1021/es800249a · Cited by 2,263
Lu, Y., Zhang, Y., Deng, Y., Jiang, W., Zhao, Y., Geng, J., Ding, L., & Ren, H. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b00183 · Cited by 2,125
Self-citationMicroplastics in bivalves cultured for human consumption
Cauwenberghe, L. V., & Janssen, C. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.06.010 · Cited by 2,105
Lusher, A. L., McHugh, M., & Thompson, R. C. (2013) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2012.11.028 · Cited by 2,075
Classify plastic waste as hazardous
Rochman, C. M., Browne, M. A., Halpern, B. S., Hentschel, B. T., Hoh, E., Karapanagioti, H. K., Rios-Mendoza, L. M., Takada, H., Teh, S., & Thompson, R. C. (2013) · Nature · doi:10.1038/494169a · Cited by 1,752
von Moos, N., Burkhardt-Holm, P., & Köhler, A. (2012) · Environmental Science & Technology · doi:10.1021/es302332w · Cited by 1,697
Ingestion and transfer of microplastics in the planktonic food web
Setälä, O., Fleming-Lehtinen, V., & Lehtiniemi, M. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2013.10.013 · Cited by 1,635
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M. & Thompson, R. C. Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.). Environ Sci Technol 42, 5026–5031 (2008). · DOI · Paper page
Cited by
Sorted by citations
Discovery and quantification of plastic particle pollution in human blood
Leslie, H. A., van Velzen, M. J. M., Brandsma, S. H., Vethaak, A. D., Garcia-Vallejo, J. J., & Lamoree, M. H. (2022) · Environment International · doi:10.1016/j.envint.2022.107199 · Cited by 3,906
Plasticenta: First evidence of microplastics in human placenta
Ragusa, A., Svelato, A., Santacroce, C., Catalano, P., Notarstefano, V., Carnevali, O., Papa, F., Rongioletti, M. C. A., Baiocco, F., Draghi, S., et al. (2021) · Environment International · doi:10.1016/j.envint.2020.106274 · Cited by 3,474
Environmental exposure to microplastics: An overview on possible human health effects
Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134455 · Cited by 2,690
Microplastics in Freshwaters and Drinking Water: Critical Review and Assessment of Data Quality
Koelmans, A. A., Mohamed Nor, N. H., Hermsen, E., Kooi, M., Mintenig, S. M., & De France, J. (2019) · Water Research · doi:10.1016/j.watres.2019.02.054 · Cited by 2,535
Detection of Various Microplastics in Human Stool
Schwabl, P., Köppel, S., Königshofer, P., Bucsics, T., Trauner, M., Reiberger, T., & Liebmann, B. (2019) · Annals of Internal Medicine · doi:10.7326/m19-0618 · Cited by 2,092
Metadata
- Authors
- Deng, Y., Zhang, Y., Lemos, B., & Ren, H.
- Affiliations
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Harvard University (US)
- Corresponding author
- Zhang, Yan
- Venue
- Scientific Reports
- Published
- 2017-04-24
- Volume
- 7
- Issue
- 1
- Pages
- 46687-46687
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5402289
- OpenAlex
- W2608368045
- Cited by
- 1,471
- References
- 50
- Citations by year
- 2026: 160 · 2025: 243 · 2024: 267 · 2023: 220 · 2022: 244 · 2021: 160 · 2020: 101 · 2019: 50 · 2018: 22 · 2017: 3
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21407076, 21304045, 21507058)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- microplastics, polystyrene microplastics, tissue accumulation, particle size effects, liver, kidney, intestine, energy metabolism, lipid metabolism, oxidative stress, neurotoxicity biomarkers, metabolomics, biomarkers, mouse model, health risks
- MeSH terms
- Animals, Environmental Exposure, Kidney, Liver, Male, Mice, Inbred ICR, Particle Size, Polystyrenes, Risk Factors, Tissue Distribution, Water Pollutants, Chemical, Biomarkers, Gastrointestinal Tract, Metabolomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
