Cited by 97Physical Activity and HealthDementia and Cognitive Impairment ResearchAdvanced MRI Techniques and Applications

Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial

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Matura, S, Fleckenstein, J, Deichmann, R, Engeroff, T, Füzéki, E, Hattingen, E, Hellweg, R, Lienerth, B +6 more·2017·Translational Psychiatry

Abstract

There is mounting evidence that aerobic exercise has a positive effect on cognitive functions in older adults. To date, little is known about the neurometabolic and molecular mechanisms underlying this positive effect. The present study used magnetic resonance spectroscopy and quantitative MRI to systematically explore the effects of physical activity on human brain metabolism and grey matter (GM) volume in healthy aging. This is a randomised controlled assessor-blinded two-armed trial (n=53) to explore exercise-induced neuroprotective and metabolic effects on the brain in cognitively healthy older adults. Participants (age >65) were allocated to a 12-week individualised aerobic exercise programme intervention (n=29) or a 12-week waiting control group (n=24). The main outcomes were the change in cerebral metabolism and its association to brain-derived neurotrophic factor (BDNF) levels as well as changes in GM volume. We found that cerebral choline concentrations remained stable after 12 weeks of aerobic exercise in the intervention group, whereas they increased in the waiting control group. No effect of training was seen on cerebral N-acetyl-aspartate concentrations, nor on markers of neuronal energy reserve or BDNF levels. Further, we observed no change in cortical GM volume in response to aerobic exercise. The finding of stable choline concentrations in the intervention group over the 3 month period might indicate a neuroprotective effect of aerobic exercise. Choline might constitute a valid marker for an effect of aerobic exercise on cerebral metabolism in healthy aging.

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  • Six months of moderate-intensity aerobic exercise significantly increased the prefrontal cortex gray matter volume in patients with depression, which was directly proportional to the amount of exercise.

    “Six months of moderate-intensity aerobic exercise significantly increased the prefrontal cortex gray matter volume in patients with depression (decreased gray matter volume is a key physiological sign of depression [65]), which was directly proportional to the amount of exercise [66].”

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Authors
Matura, S., Fleckenstein, J., Deichmann, R., Engeroff, T., Füzéki, E., Hattingen, E., Hellweg, R., Lienerth, B., Pilatus, U., Schwarz, S., Tesky, V. A., Vogt, L., Banzer, W., & Pantel, J.
Affiliations
  • Goethe University Frankfurt (DE)
  • University Hospital Frankfurt (DE)
  • Stiftung Charité (DE)
Corresponding author
Matura, S
Venue
Translational Psychiatry
Published
2017-07-18
Volume
7
Issue
7
Pages
e1172-e1172
ISSN
2158-3188 (ISSN-L)
OpenAlex
W2725836425
Cited by
97
References
44
Citations by year
2026: 9 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 18 · 2020: 7 · 2019: 15 · 2018: 8 · 2017: 2
FWCI
6.47
Type
journal article
Language
en
Open access
Locations
  • Translational Psychiatry (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by-nc-sa)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
aerobic exercise, brain metabolism, gray matter volume, older adults, healthy aging, choline, N-acetylaspartate, brain-derived neurotrophic factor, neuroprotection, cognitive function, brain energy metabolism, cortical gray matter
MeSH terms
Aged, Aged, 80 and over, Aging, Brain, Choline, Female, Humans, Magnetic Resonance Imaging, Male, Magnetic Resonance Spectroscopy, Exercise, Brain-Derived Neurotrophic Factor, Gray Matter

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