Vascular hippocampal plasticity after aerobic exercise in older adults.
Open accessAbstract
Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical region for recall and recognition memory. In a mechanistic proof-of-concept intervention over 3 months, we investigated whether healthy older adults (60-77 years) also show such plasticity. Regional cerebral blood flow (rCBF) and volume (rCBV) were measured with gadolinium-based perfusion imaging (3 Tesla magnetic resonance image (MRI)). Hippocampal volumes were assessed by high-resolution 7 Tesla MRI. Fitness improvement correlated with changes in hippocampal perfusion and hippocampal head volume. Perfusion tended to increase in younger, but to decrease in older individuals. The changes in fitness, hippocampal perfusion and volume were positively related to changes in recognition memory and early recall for complex spatial objects. Path analyses indicated that fitness-related changes in complex object recognition were modulated by hippocampal perfusion. These findings indicate a preserved capacity of the aging human hippocampus for functionally relevant vascular plasticity, which decreases with progressing age.
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Aerobic exercise-induced growth in hippocampal volume was correlated with improved performances on a complex figure test of spatial object recognition (r = 0.37).
“In some cases the AE induced growth in hippocampal volume was correlated with improved performances on a computerized spatial memory task (r = 0.28; Erickson et al., 2011) or on a complex figure test of spatial object recognition (r = 0.37; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Maass et al., 2015
Increases in cerebral blood flow in the human hippocampus have been correlated with improved performance on episodic memory tasks.
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Maass et al., 2015
The positive influence of improving vascularization may extend beyond a greater supply of oxygen and glucose through prompting the release of neurotrophic factors or through facilitating other neuroplastic mechanisms like synaptic plasticity or neurogenesis.
“The positive influence of improving vascularization may extend beyond a greater supply of oxygen and glucose through prompting the release of neurotrophic factors (the influence of which will be discussed below; Maass et al., 2015) or through facilitating other neuroplastic mechanisms like synaptic plasticity (Christie et al., 2008) or neurogenesis (Palmer et al., 2000; Pereira et al., 2007; Boe”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Maass et al., 2015
Greater cerebral blood flow in the human hippocampus has been demonstrated.
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Maass et al., 2015
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- Authors
- Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., Ahrens, D., Heinze, H.-J., Müller, N. G., & Düzel, E.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Max Planck Institute for Human Development (DE)
- Karolinska Institutet (SE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Corresponding author
- Düzel, E
- Venue
- Molecular Psychiatry
- Published
- 2014-10-14
- Volume
- 20
- Issue
- 5
- Pages
- 585-593
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1992403138
- Cited by
- 382
- References
- 62
- Citations by year
- 2026: 30 · 2025: 32 · 2024: 29 · 2023: 35 · 2022: 55 · 2021: 44 · 2020: 34 · 2019: 32 · 2018: 27 · 2017: 29 · 2016: 20 · 2015: 13
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Stichting af Jochnick Foundation
- Vetenskapsrådet
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Swedish Brain Power
- Leibniz-Gemeinschaft
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- aerobic exercise, older adults, regional cerebral blood flow, hippocampal volume, fitness, recognition memory, aging
- MeSH terms
- Aged, Analysis of Variance, Cerebrovascular Circulation, Cognition, Female, Gadolinium, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen Consumption, Mental Recall, Statistics as Topic, Verbal Learning, Exercise
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