Physical Activity, Brain Plasticity, and Alzheimer's Disease
Open accessAbstract
In this review we summarize the epidemiological, cross-sectional, and interventional studies examining the association between physical activity and brain volume, function, and risk for Alzheimer's disease. The epidemiological literature provides compelling evidence that greater amounts of physical activity are associated with a reduced risk of dementia in late life. In addition, randomized interventions using neuroimaging tools have reported that participation in physical activity increases the size of prefrontal and hippocampal brain areas, which may lead to a reduction in memory impairments. Consistent with these findings, longitudinal studies using neuroimaging tools also find that the volume of prefrontal and hippocampal brain areas are larger in individuals who engaged in more physical activity earlier in life. We conclude from this review that there is convincing evidence that physical activity has a consistent and robust association with brain regions implicated in age-related cognitive decline and Alzheimer's disease. In addition to summarizing this literature we provide recommendations for future research on physical activity and brain health.
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Exercise is neuroprotective, delays the onset and progression, and reduces the risk for many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
“Exercise has also been shown to be neuroprotective, to delay the onset and progression, and reduce the risk for many neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) [17, 39, 58, 89, 108, 163, 193, 199].”
From The neuropathology of sport (2014) · cites this paper as [58]
Increased baseline physical activity reduces the risk of developing dementia by 28% and of developing Alzheimer's disease by 45%.
“Prospective epidemiological studies show that increased baseline physical activity reduces the risk of developing dementia by 28 % and of developing AD by 45 % [58, 83].”
From The neuropathology of sport (2014) · cites this paper as [58]
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- Authors
- Erickson, K. I., Weinstein, A. M., & Lopez, O. L.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Erickson, Kirk I.
- Venue
- Archives of Medical Research
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 43
- Issue
- 8
- Pages
- 615-621
- ISSN
- 0066-6769 (ISSN-L)
- 0188-4409
- PMC
- PMC3567914
- OpenAlex
- W1992551649
- Cited by
- 288
- References
- 33
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 17 · 2023: 20 · 2022: 22 · 2021: 28 · 2020: 16 · 2019: 16 · 2018: 22 · 2017: 21 · 2016: 16 · 2015: 36 · 2014: 32 · 2013: 9 · 2012: 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Archives of Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005133, P30AG024827)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK095172)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- physical activity, Alzheimer's disease, neuroplasticity, brain volume, dementia risk, hippocampus, prefrontal cortex, memory impairment, age-related cognitive decline, neuroimaging, exercise intervention
- MeSH terms
- Aging, Alzheimer Disease, Brain, Dementia, Hippocampus, Humans, Longitudinal Studies, Memory, Motor Activity, Neuronal Plasticity, Physical Fitness, Exercise, Neuroimaging
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