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Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
Open accessAbstract
The indolocarbazole family of natural products, including the biosynthetically related bisindolylmaleimides, is reviewed (with 316 references cited). The isolation of indolocarbazoles from natural sources and the biosynthesis of this class of compounds are thoroughly reviewed, including recent developments in molecular genetics, enzymology and metabolic engineering. The biological activities and underlying modes of action displayed by natural and synthetic indolocarbazoles is also presented, with an emphasis on the development of analogs that have entered clinical trials for its future use against cancer or other diseases.
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AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
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Delost, M. D., Smith, D. T., Anderson, B. J., & Njardarson, J. T. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00876 · Cited by 409
Flavoenzymes: Versatile catalysts in biosynthetic pathways
Walsh, C. T., & Wencewicz, T. A. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20069d · Cited by 373
Blunt, J. W., Copp, B. R., Hu, W.-P., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2008) · Natural Product Reports · doi:10.1039/b701534h · Cited by 365
Antitumor compounds from marine actinomycetes
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Metadata
- Authors
- Sánchez, C., Méndez, C., & Salas, J. A.
- Venue
- Nat. Prod. Rep.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 23
- Issue
- 6
- Pages
- 1007-1045
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2162655337
- Cited by
- 407
- References
- 1
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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