The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Inertial microfluidics for continuous particle separation in spiral microchannels
Open accessAbstract
In this work we report on a simple inertial microfluidic device that achieves continuous multi-particle separation using the principle of Dean-coupled inertial migration in spiral microchannels. The dominant inertial forces coupled with the Dean rotational force due to the curvilinear microchannel geometry cause particles to occupy a single equilibrium position near the inner microchannel wall. The position at which particles equilibrate is dependent on the ratio of the inertial lift to Dean drag forces. Using this concept, we demonstrate, for the first time, a spiral lab-on-a-chip (LOC) for size-dependent focusing of particles at distinct equilibrium positions across the microchannel cross-section from a multi-particle mixture. The individual particle streams can be collected with an appropriately designed outlet system. To demonstrate this principle, a 5-loop Archimedean spiral microchannel with a fixed width of 500 microm and a height of 130 microm was used to simultaneously and continuously separate 10 microm, 15 microm, and 20 microm polystyrene particles. The device exhibited 90% separation efficiency. The versatility of the device was demonstrated by separating neuroblastoma and glioma cells with 80% efficiency and high relative viability (>90%). The achieved throughput of approximately 1 million cells/min is substantially higher than the sorting rates reported by other microscale sorting methods and is comparable to the rates obtained with commercial macroscale flow cytometry techniques. The simple planar structure and high throughput offered by this passive microfluidic approach make it attractive for LOC devices in biomedical and environmental applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Continuous inertial focusing, ordering, and separation of particles in microchannels
Di Carlo, D., Irimia, D., Tompkins, R. G., & Toner, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704958104 · Cited by 1,708
XVI.Note on the motion of fluid in a curved pipe
Dean, W. R. (1927) · The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science · doi:10.1080/14786440708564324 · Cited by 1,661
Continuous Particle Separation Through Deterministic Lateral Displacement
Huang, L. R., Cox, E. C., Austin, R. H., & Sturm, J. C. (2004) · Science · doi:10.1126/science.1094567 · Cited by 1,634
Radial Particle Displacements in Poiseuille Flow of Suspensions
SEGRÉ, G., & SILBERBERG, A. (1961) · Nature · doi:10.1038/189209a0 · Cited by 1,206
A microfabricated fluorescence-activated cell sorter
Fu, A. Y., Spence, C., Scherer, A., Arnold, F. H., & Quake, S. R. (1999) · Nature Biotechnology · doi:10.1038/15095 · Cited by 878
Continuous flow separations in microfluidic devices
Pamme, N. (2007) · Lab on a Chip · doi:10.1039/b712784g · Cited by 770
Yamada, M., Nakashima, M., & Seki, M. (2004) · Analytical Chemistry · doi:10.1021/ac049863r · Cited by 746
Continuous particle separation in spiral microchannels using dean flows and differential migration
Bhagat, A. A. S., Kuntaegowdanahalli, S. S., & Papautsky, I. (2008) · Lab on a Chip · doi:10.1039/b807107a · Cited by 656
Self-citationToner, M., & Irimia, D. (2005) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.7.011205.135108 · Cited by 623
Micro Total Analysis Systems: Latest Achievements
West, J., Becker, M., Tombrink, S., & Manz, A. (2008) · Analytical Chemistry · doi:10.1021/ac800680j · Cited by 423
Critical particle size for fractionation by deterministic lateral displacement
Inglis, D. W., Davis, J. A., Austin, R. H., & Sturm, J. C. (2006) · Lab on a Chip · doi:10.1039/b515371a · Cited by 421
Equilibrium Separation and Filtration of Particles Using Differential Inertial Focusing
Di Carlo, D., Edd, J. F., Irimia, D., Tompkins, R. G., & Toner, M. (2008) · Analytical Chemistry · doi:10.1021/ac702283m · Cited by 413
Inertial microfluidics for continuous particle filtration and extraction
Bhagat, A. A. S., Kuntaegowdanahalli, S. S., & Papautsky, I. (2009) · Microfluidics and Nanofluidics · doi:10.1007/s10404-008-0377-2 · Cited by 334
Self-citationA passive planar micromixer with obstructions for mixing at low Reynolds numbers
Bhagat, A. A. S., Peterson, E. T. K., & Papautsky, I. (2007) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/17/5/023 · Cited by 305
Self-citationModular concept of a laboratory on a chip for chemical and biochemical analysis
Blankenstein, G., & Larsen, U. (1998) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(97)00109-7 · Cited by 158
Membrane-free microfiltration by asymmetric inertial migration
Seo, J., Lean, M. H., & Kole, A. (2007) · Applied Physics Letters · doi:10.1063/1.2756272 · Cited by 139
Size and shape separation of gold nanoparticles with preparative gel electrophoresis
Xu, X., Caswell, K. K., Tucker, E., Kabisatpathy, S., Brodhacker, K. L., & Scrivens, W. A. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.07.056 · Cited by 133
Liu, F., Lin, Y., & Wu, C. (2004) · Analytica Chimica Acta · doi:10.1016/j.aca.2004.08.052 · Cited by 84
Hedlund, E., Pruszak, J., Ferree, A. W., Viñuela, Á., Hong, S., Ole Isacson, A., & Kim, K. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0540 · Cited by 69
Cited by
Di Carlo, D. (2009) · Lab on a Chip · doi:10.1039/b912547g · Cited by 1,627
Fundamentals and applications of inertial microfluidics: a review
Zhang, J., Yan, S., Yuan, D., Alici, G., Nguyen, N.-T., Ebrahimi Warkiani, M., & Li, W. (2016) · Lab on a Chip · doi:10.1039/c5lc01159k · Cited by 1,017
Label-free cell separation and sorting in microfluidic systems
Gossett, D. R., Weaver, W. M., Mach, A. J., Hur, S. C., Tse, H. T. K., Lee, W., Amini, H., & Di Carlo, D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3721-9 · Cited by 930
Amini, H., Lee, W., & Di Carlo, D. (2014) · Lab on a Chip · doi:10.1039/c4lc00128a · Cited by 722
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Self-citation
Metadata
- Authors
- Kuntaegowdanahalli, S. S., Bhagat, A. A. S., Kumar, G., & Papautsky, I.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 9
- Issue
- 20
- Pages
- 2973
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2168705567
- Cited by
- 708
- References
- 19
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
