The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP)
Open accessAbstract
Circulating tumor cells (CTCs) are highly correlated with the invasive behavior of cancer, so their isolations and quantifications are important for biomedical applications such as cancer prognosis and measuring the responses to drug treatments. In this paper, we present the development of a microfluidic device for the separation of CTCs from blood cells based on the physical properties of cells. For use as a CTC model, we successfully separated human breast cancer cells (MCF-7) from a spiked blood cell sample by combining multi-orifice flow fractionation (MOFF) and dielectrophoretic (DEP) cell separation technique. Hydrodynamic separation takes advantage of the massive and high-throughput filtration of blood cells as it can accommodate a very high flow rate. DEP separation plays a role in precise post-processing to enhance the efficiency of the separation. The serial combination of these two different sorting techniques enabled high-speed continuous flow-through separation without labeling. We observed up to a 162-fold increase in MCF-7 cells at a 126 µL min(-1) flow rate. Red and white blood cells were efficiently removed with separation efficiencies of 99.24% and 94.23% respectively. Therefore, we suggest that our system could be used for separation and detection of CTCs from blood cells for biomedical applications.
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Cites
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Cited by
Fundamentals and applications of inertial microfluidics: a review
Zhang, J., Yan, S., Yuan, D., Alici, G., Nguyen, N.-T., Ebrahimi Warkiani, M., & Li, W. (2016) · Lab on a Chip · doi:10.1039/c5lc01159k · Cited by 1,017
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Molecular analysis of circulating tumour cells—biology and biomarkers
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Circulating Tumor Cells and Circulating Tumor DNA
Alix-Panabières, C., Schwarzenbach, H., & Pantel, K. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-062310-094219 · Cited by 485
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Metadata
- Authors
- Moon, H.-S., Kwon, K., Kim, S.-I., Han, H., Sohn, J., Lee, S., & Jung, H.-I.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 11
- Issue
- 6
- Pages
- 1118
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2125051097
- Cited by
- 437
- References
- 23
- FWCI
- 19.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Moon, H.-S., Kwon, K., Kim, S.-I., Han, H., Sohn, J., Lee, S., & Jung, H.-I. (2011). Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP). Lab on a Chip. https://doi.org/10.1039/c0lc00345j
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