The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles
Open accessAbstract
The understanding of the interactions between nanomaterials and proteins is of extreme importance in medicine. In a biological fluid, proteins can adsorb and associate with nanoparticles, which can have significant impact on the biological behavior of the proteins and the nanoparticles. We report here on the interactions of iron saturated human transferrin protein with both bare and polyvinyl alcohol coated superparamagnetic iron oxide nanoparticles (SPIONs). The exposure of human transferrin to SPIONs results in the release of iron, which changes the main function of the protein, which is the transport of iron among cells. After removal of the magnetic nanoparticles, the original protein conformation is not recovered, indicating irreversible changes in transferrin conformation: from a compact to an open structure.
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Cites
Mahmoudi, M., Simchi, A., Imani, M., Shokrgozar, M. A., Milani, A. S., Häfeli, U. O., & Stroeve, P. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.08.044 · Cited by 294
Metal-induced Conformational Changes in Transferrins
Grossmann, J. G., Neu, M., Evans, R. W., Lindley, P. F., Appel, H., & Hasnain, S. S. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1063 · Cited by 67
Cited by
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Self-citationMagnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
Laurent, S., Dutz, S., Häfeli, U. O., & Mahmoudi, M. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.04.003 · Cited by 1,326
Self-citationSoenen, S. J., Rivera-Gil, P., Montenegro, J.-M., Parak, W. J., De Smedt, S. C., & Braeckmans, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.08.001 · Cited by 699
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 538
Nanoparticle protein corona: from structure and function to therapeutic targeting
Bashiri, G., Padilla, M. S., Swingle, K. L., Shepherd, S. J., Mitchell, M. J., & Wang, K. (2023) · Lab on a Chip · doi:10.1039/d2lc00799a · Cited by 296
Metadata
- Authors
- Mahmoudi, M., Shokrgozar, M. A., Sardari, S., Moghadam, M. K., Vali, H., Laurent, S., & Stroeve, P.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 3
- Issue
- 3
- Pages
- 1127-38
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2069682319
- Cited by
- 204
- References
- 2
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- green
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