The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells
Open accessAbstract
Nanoscale coordination polymers (NCPs) have been demonstrated as an interesting platform for drug delivery, as they possess many advantages over small-molecule chemotherapeutics such as high payloads, lower systemic toxicity, tunability, and enhanced tumor uptake. Existing formulations for the delivery of methotrexate (MTX), an antifolate cancer drug, have very low drug loadings. Herein, we report the incorporation of MTX as a building block in an NCP formulation with exceptionally high drug loadings (up to 79.1 wt%) and the selective delivery of the NCP to cancer cells. Encapsulation of the NCP in a functionalized lipid bilayer allows for targeted delivery and controlled release to cancer cells. A phosphor can be doped into the NCPs for monitoring particle uptake by optical imaging. The lipid-coated and anisamide-targeted NCPs have superior in vitro efficacy against acute lymphoblastic leukemia cells when compared to the free drug.
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Cites
Metal-organic framework materials as catalysts
Lee, J., Farha, O. K., Roberts, J., Scheidt, K. A., Nguyen, S. T., & Hupp, J. T. (2009) · Chemical Society Reviews · doi:10.1039/b807080f · Cited by 7,969
Nanoparticle therapeutics: an emerging treatment modality for cancer
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McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000048 · Cited by 1,256
Cited by
Best Practices for the Synthesis, Activation, and Characterization of Metal–Organic Frameworks
Howarth, A. J., Peters, A. W., Vermeulen, N. A., Wang, T. C., Hupp, J. T., & Farha, O. K. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.6b02626 · Cited by 746
Application of zirconium MOFs in drug delivery and biomedicine
Abánades Lázaro, I., & Forgan, R. S. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.09.009 · Cited by 678
Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Nanoscale metal–organic frameworks for phototherapy of cancer
Lan, G., Ni, K., & Lin, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.007 · Cited by 420
Self-citationThe surface chemistry of metal–organic frameworks
McGuire, C. V., & Forgan, R. S. (2015) · Chemical Communications · doi:10.1039/c4cc04458d · Cited by 396
Metadata
- Authors
- Huxford, R. C., deKrafft, K. E., Boyle, W. S., Liu, D., & Lin, W.
- Venue
- Chem. Sci.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 3
- Issue
- 1
- Pages
- 198-204
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- OpenAlex
- W2041860120
- Cited by
- 177
- References
- 3
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- green
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