The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Drug repositioning by structure-based virtual screening
Abstract
Approved drugs have favourable or validated pharmacokinetic properties and toxicological profiles, and the repositioning of existing drugs for new indications can potentially avoid expensive costs associated with early-stage testing of the hit compounds. In recent years, technological advances in virtual screening methodologies have allowed medicinal chemists to rapidly screen drug libraries for therapeutic activity against new biomolecular targets in a cost-effective manner. This review article outlines the basic principles and recent advances in structure-based virtual screening and highlights the powerful synergy of in silico techniques in drug repositioning as demonstrated in several recent reports.
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Citations
Cites
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Cited by
Review of Drug Repositioning Approaches and Resources
Xue, H., Li, J., Xie, H., & Wang, Y. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.24612 · Cited by 614
An Overview of Scoring Functions Used for Protein–Ligand Interactions in Molecular Docking
Li, J., Fu, A., & Zhang, L. (2019) · Interdisciplinary Sciences: Computational Life Sciences · doi:10.1007/s12539-019-00327-w · Cited by 434
Recent development of biotin conjugation in biological imaging, sensing, and target delivery
Ren, W. X., Han, J., Uhm, S., Jang, Y. J., Kang, C., Kim, J.-H., & Kim, J. S. (2015) · Chemical Communications · doi:10.1039/c5cc03075g · Cited by 393
Performance of machine-learning scoring functions in structure-based virtual screening.
Wójcikowski, M., Ballester, P. J., & Siedlecki, P. (2017) · Scientific Reports · doi:10.1038/srep46710 · Cited by 364
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Metadata
- Authors
- Ma, D.-L., Chan, D. S.-H., & Leung, C.-H.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 42
- Issue
- 5
- Pages
- 2130
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2020639753
- Cited by
- 232
- References
- 11
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
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