The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles
Abstract
Herein, we report a core–shell pH-responsive drug-carrier based on chitosan-coated mesoporous silica nanospheres. The efficient positively charged polymer (chitosan) coating is realized by the phosphoramidate covalent bonding between phosphonate groups on the surface of the mesoporous silica nanoparticles (MSNs) and amino groups on chitosan. A pH-responsive release of ibuprofen has been achieved by varying the shell structure of positively charged chitosan in the designed pH 4.0–7.4 solution. Under basic conditions, chitosan forms a gel like structure which is insoluble and hence prevents ibuprofen release at pH 7.4. When the pH is below its PI (6.3), the drug has been released due to protonation of the amino group on chitosan. These results imply that the chitosan coated-MSNs are promising platforms to construct pH-responsive controlled drug delivery systems.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Silica‐Based Mesoporous Organic–Inorganic Hybrid Materials
Hoffmann, F., Cornelius, M., Morell, J., & Fröba, M. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503075 · Cited by 3,089
Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica
Mal, N. K., Fujiwara, M., & Tanaka, Y. (2003) · Nature · doi:10.1038/nature01362 · Cited by 1,094
Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
Lu, J., Liong, M., Zink, J. I., & Tamanoi, F. (2007) · Small · doi:10.1002/smll.200700005 · Cited by 1,012
Zhu, Y., Shi, J., Shen, W., Dong, X., Feng, J., Ruan, M., & Li, Y. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501500 · Cited by 1,011
Magnetic Nanocomposites with Mesoporous Structures: Synthesis and Applications
Liu, J., Qiao, S. Z., Hu, Q. H., & (Max) Lu, G. Q. (2011) · Small · doi:10.1002/smll.201001402 · Cited by 753
Self-citationGan, Q., & Wang, T. (2007) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2007.04.009 · Cited by 711
Vivero-Escoto, J. L., Slowing, I. I., Wu, C.-W., & Lin, V. S.-Y. (2009) · Journal of the American Chemical Society · doi:10.1021/ja900025f · Cited by 647
Muhammad, F., Guo, M., Qi, W., Sun, F., Wang, A., Guo, Y., & Zhu, G. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200328s · Cited by 603
Rosenholm, J. M., Sahlgren, C., & Lindén, M. (2010) · Nanoscale · doi:10.1039/c0nr00156b · Cited by 572
Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers
Popat, A., Hartono, S. B., Stahr, F., Liu, J., Qiao, S. Z., & Qing (Max) Lu, G. (2011) · Nanoscale · doi:10.1039/c1nr10224a · Cited by 548
Self-citation
Cited by
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Song, Y., Li, Y., Xu, Q., & Liu, Z. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s117495 · Cited by 258
Nanocarriers for targeted drug delivery
Shah, A., Aftab, S., Nisar, J., Ashiq, M. N., & Iftikhar, F. J. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102426 · Cited by 161
Metadata
- Authors
- Popat, A., Liu, J., Lu, G. Q. (., & Qiao, S. Z.
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 22
- Issue
- 22
- Pages
- 11173
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W1971859416
- Cited by
- 321
- References
- 29
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles. https://app.cochat.ai/papers/10.1039/c2jm30501a
- The paper
- Popat, A., Liu, J., Lu, G. Q. (., & Qiao, S. Z. (2012). A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles. Journal of Materials Chemistry. https://doi.org/10.1039/c2jm30501a
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
