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Cited by 255Trace Elements in HealthHeavy Metal Exposure and ToxicityMetal complexes synthesis and properties

Mammalian metallothioneins: properties and functions

Babula, Petr, Masarik, Michal, Adam, Vojtech, Eckschlager, Tomas, Stiborova, Marie, Trnkova, Libuse, Skutkova, Helena, Provaznik, Ivo +2 more·2012·Metallomics
DOI 10.1039/c2mt20081c
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Abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(ii) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs. The connection between zinc(ii) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to the action of these proteins on cell proliferation and potential negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

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  • The body is physiologically adept at transporting and storing larger concentrations of zinc with no risk of producing reactive oxygen species, unlike high concentrations of copper.

    “Because of this, the body is physiologically adept at transporting and storing larger concentrations of zinc with no risk of producing reactive oxygen species, a consequence of high concentrations of copper and mediators of acute and chronic inflammatory pain (32,33).”

    From Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD) (2022) · cites this paper as [33]

    Section 2 describes metallothioneins storing and transporting zinc, while sections 3.2 and 4 link redox-active copper to oxygen radicals and describe zinc’s protective effects. The paper does not establish that the body can store larger concentrations of zinc with no risk of producing reactive oxygen species, nor does these passages link copper to inflammatory pain. Page numbers were not available in our copy’s passages. (LLM, conf=0.86)

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Authors
Babula, P., Masarik, M., Adam, V., Eckschlager, T., Stiborova, M., Trnkova, L., Skutkova, H., Provaznik, I., Hubalek, J., & Kizek, R.
Affiliations
University of Veterinary Sciences Brno (CZ)
ORCID
Babula, Petr
Venue
Metallomics
Publisher
Oxford University Press (OUP)
Published
2012
Volume
4
Issue
8
Pages
739
ISSN
  • 1756-5901 (ISSN-L)
  • 1756-591X
DOI
10.1039/c2mt20081c
OpenAlex
W2136294249
Cited by
255
References
212
Citations by year
2026: 8 · 2025: 11 · 2024: 14 · 2023: 17 · 2022: 21 · 2021: 19 · 2020: 13 · 2019: 11 · 2018: 19 · 2017: 23 · 2016: 25 · 2015: 23 · 2014: 35 · 2013: 12 · 2012: 3
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
  • Metallomics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Central European Institute of Technology (CZ.1.05/1.1.00/02.0068., CYTORES GA CR P301/10/0356, CZ.1.05/1.1.00/02)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords
metallothionein, zinc, reactive oxygen species, heavy metal ions, antioxidant activity, free radicals, cell proliferation, drug resistance, cysteine-rich proteins, metal ion binding
MeSH terms
Amino Acid Sequence, Animals, Antineoplastic Agents, Cadmium, Free Radicals, Glutathione, Humans, Metallothionein, Metals, Models, Molecular, Molecular Sequence Data, Neoplasms, Apoptosis, Drug Resistance, Neoplasm, Cell Proliferation

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