Fabrication of a shape memory hydrogel based on imidazole–zinc ion coordination for potential cell-encapsulating tubular scaffold application
Abstract
A dipole–dipole reinforced copolymer hydrogel was synthesized by the one-step photopolymerization of vinylimidazole (VI) and acrylonitrile (AN) comonomer in the presence of a polyethylene glycol-based crosslinker. The mechanical properties of PVI–AN gels were tremendously increased by only chelating several mmol L−1 zinc ions, which was shown to firmly lock the temporary shape of the gel. Extraction of zinc ions by a complexing agent could facilitate the recovery of a permanent shape, and the memory behavior was reversible. The PVI–AN hydrogels supported the growth of L929 cells. The cell-seeded flat hydrogel sheet was folded into a temporary tubular scaffold and fixed in a culture medium containing 5 mmol L−1 zinc ions. After unfolding the tube, the exposed L929 cells were shown to adhere well on the surface of the gel. It is anticipated that this cell-loaded SM hydrogel could be fixed to a desired shape in vitro by small numbers of zinc ions for a potential implantable tissue engineering scaffold.
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ZnO SMCs include imidazole-zinc ion coordinated shape-memory hydrogel, triple-shape-memory poly(acrylonitrile 2-methacryloyloxyethyl phosphorylcholine) from dipole-dipole-zinc ion coordination, epoxy-based SMP containing metallosupramolecular unit, and ZnO NRs in PU matrix.
“They are containing imidazole-zinc ion for the production of coordinated shapememory hydrogel [174], triple-shape-memory poly(acrylonitrile 2-methacryloyloxyethyl phosphorylcholine) from dipoledipole-zinc ion coordination [175] or epoxy-based SMP containing metallosupramolecular unit formed by coordinating 2,6-bis( N -methyl-benzimidazolyl)-pyridine ligands to zinc di[bis(trifluoromethylsulfonyl)-”
From Shape-memory polymers for multiple applications in the materials world (2016) · cites this paper as [174]
The above two features differ notably from common shape memory hydrogels for which shape changing kinetics is strongly affected by device dimension due to inside-and-out water diffusion.
“The above two features differ notably from common shape memory hydrogels 21-24 for which the shape changing kinetics is strongly affected by the device dimension due to the inside-and-out water diffusion 25 .”
From Shape memory polymer with programmable recovery onset (2023) · cites this paper as [25]
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- Authors
- Nan, W., Wang, W., Gao, H., & Liu, W.
- Affiliations
- Tianjin University (CN)
- Corresponding author
- Liu, Wenguang
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 9
- Issue
- 1
- Pages
- 132-137
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2093812514
- Cited by
- 121
- References
- 24
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 5 · 2013: 4
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Soft Matter (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- shape memory hydrogels, vinylimidazole, acrylonitrile copolymers, photopolymerization, shape recovery, cell encapsulation, tubular scaffolds, L929 fibroblasts, mechanical properties
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