Cited by 121Hydrogels: synthesis, properties, applicationsAdvanced Materials and MechanicsSupramolecular Self-Assembly in Materials

Fabrication of a shape memory hydrogel based on imidazole–zinc ion coordination for potential cell-encapsulating tubular scaffold application

Nan, Wenjing, Wang, Wei, Gao, Han, Liu, Wenguang·2013·Soft Matter

Abstract

A dipole–dipole reinforced copolymer hydrogel was synthesized by the one-step photopolymerization of vinylimidazole (VI) and acrylonitrile (AN) comonomer in the presence of a polyethylene glycol-based crosslinker. The mechanical properties of PVI–AN gels were tremendously increased by only chelating several mmol L−1 zinc ions, which was shown to firmly lock the temporary shape of the gel. Extraction of zinc ions by a complexing agent could facilitate the recovery of a permanent shape, and the memory behavior was reversible. The PVI–AN hydrogels supported the growth of L929 cells. The cell-seeded flat hydrogel sheet was folded into a temporary tubular scaffold and fixed in a culture medium containing 5 mmol L−1 zinc ions. After unfolding the tube, the exposed L929 cells were shown to adhere well on the surface of the gel. It is anticipated that this cell-loaded SM hydrogel could be fixed to a desired shape in vitro by small numbers of zinc ions for a potential implantable tissue engineering scaffold.

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Crossref · 10.1039/c2sm26918j

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24 of 24 references verified0 citation errors · 0 not checkable

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  • ZnO SMCs include imidazole-zinc ion coordinated shape-memory hydrogel, triple-shape-memory poly(acrylonitrile 2-methacryloyloxyethyl phosphorylcholine) from dipole-dipole-zinc ion coordination, epoxy-based SMP containing metallosupramolecular unit, and ZnO NRs in PU matrix.

    “They are containing imidazole-zinc ion for the production of coordinated shapememory hydrogel [174], triple-shape-memory poly(acrylonitrile 2-methacryloyloxyethyl phosphorylcholine) from dipoledipole-zinc ion coordination [175] or epoxy-based SMP containing metallosupramolecular unit formed by coordinating 2,6-bis( N -methyl-benzimidazolyl)-pyridine ligands to zinc di[bis(trifluoromethylsulfonyl)-”
  • The above two features differ notably from common shape memory hydrogels for which shape changing kinetics is strongly affected by device dimension due to inside-and-out water diffusion.

    “The above two features differ notably from common shape memory hydrogels 21-24 for which the shape changing kinetics is strongly affected by the device dimension due to the inside-and-out water diffusion 25 .”

    From Shape memory polymer with programmable recovery onset (2023) · cites this paper as [25]

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Authors
Nan, W., Wang, W., Gao, H., & Liu, W.
Affiliations
Tianjin University (CN)
Corresponding author
Liu, Wenguang
Venue
Soft Matter
Published
2013
Volume
9
Issue
1
Pages
132-137
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2093812514
Cited by
121
References
24
Citations by year
2026: 1 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 5 · 2013: 4
FWCI
2.79
Type
journal article
Language
en
Open access
closed
Locations
Soft Matter (publishedVersion)
Funders
National Natural Science Foundation of China
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
Keywords
shape memory hydrogels, vinylimidazole, acrylonitrile copolymers, photopolymerization, shape recovery, cell encapsulation, tubular scaffolds, L929 fibroblasts, mechanical properties

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