Emerging micro- and nanotechnology based synthetic approaches for insulin delivery

Pulmonary Delivery of Free and Liposomal Insulin

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Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin

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Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs

Cheng, J., Teply, B. A., Jeong, S. Y., Yim, C. H., Ho, D. C., Sherifi, I., Jon, S., Farokhzad, O. C., Khademhosseini, A., & Langer, R. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-9444-5 · Cited by 134

Phenylboronic Acid-Based Complex Micelles with Enhanced Glucose-Responsiveness at Physiological pH by Complexation with Glycopolymer

Ma, R., Yang, H., Li, Z., Liu, G., Sun, X., Liu, X., An, Y., & Shi, L. (2012) · Biomacromolecules · doi:10.1021/bm3012715 · Cited by 130

Effect of cell-penetrating peptides on the nasal absorption of insulin

Khafagy, E., Morishita, M., Isowa, K., Imai, J., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.09.076 · Cited by 130

Preparation, Characterization, and Oral Delivery of Insulin Loaded Carboxylated Chitosan Grafted Poly(methyl methacrylate) Nanoparticles

Cui, F., Qian, F., Zhao, Z., Yin, L., Tang, C., & Yin, C. (2009) · Biomacromolecules · doi:10.1021/bm900035u · Cited by 130

Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery

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Thiolated chitosan microparticles: A vehicle for nasal peptide drug delivery

Krauland, A. H., Guggi, D., & Bernkop‐Schnürch, A. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.016 · Cited by 126

Cyclic AMP dynamics in the pancreatic β-cell

Tengholm, A. (2012) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.724732 · Cited by 126

Crystallographic Evidence for Dual Coordination Around Zinc in the T3R3 Human Insulin Hexamer

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Comparison of insulin detemir and insulin glargine in subjects with Type 1 diabetes using intensive insulin therapy

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Nanotechnology‐Enabled Closed Loop Insulin Delivery Device: In Vitro and In Vivo Evaluation of Glucose‐Regulated Insulin Release for Diabetes Control

Gordijo, C. R., Koulajian, K., Shuhendler, A. J., Bonifácio, L. D. S., Huang, H. Y., Chiang, S., Ozin, G. A., Giacca, A., & Wu, X. Y. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201001762 · Cited by 124

A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

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Glucose-Responsive Vehicles Containing Phenylborate Ester for Controlled Insulin Release at Neutral pH

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Long-term safety, efficacy and side-effects of continuous subcutaneous insulin infusion treatment for Type 1 (insulin-dependent) diabetes mellitus: a one centre experience

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Polysialylated insulin: synthesis, characterization and biological activity in vivo

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Glucose‐Responsive Bioinorganic Nanohybrid Membrane for Self‐Regulated Insulin Release

Gordijo, C. R., Shuhendler, A. J., & Wu, X. Y. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200901581 · Cited by 119

Rapid Pharmacokinetics of Intradermal Insulin Administered Using Microneedles in Type 1 Diabetes Subjects

Gupta, J., Felner, E. I., & Prausnitz, M. R. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2010.0204 · Cited by 118

Self‐Assembled pH‐Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs

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Control of insulin secretion: a model involving Ca2+, cAMP and diacylglycerol

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Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles

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A Randomized, Controlled Study of Once-Daily LY2605541, a Novel Long-Acting Basal Insulin, Versus Insulin Glargine in Basal Insulin–Treated Patients With Type 2 Diabetes

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cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets.

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Amphiphilic Random Glycopolymer Based on Phenylboronic Acid: Synthesis, Characterization, and Potential as Glucose-Sensitive Matrix

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In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

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Bioadhesive interaction and hypoglycemic effect of insulin-loaded lectin–microparticle conjugates in oral insulin delivery system

Kim, B.-Y., Jeong, J. H., Park, K., & Kim, J.-D. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.032 · Cited by 108

Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers

Pillai, O., Nair, V. B., & Panchagnula, R. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.032 · Cited by 108

Oral immunization against hepatitis B using bile salt stabilized vesicles (bilosomes)

Shukla, A., Khatri, K., Gupta, P. N., et al. (2008) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3k01m · Cited by 108

Pharmacokinetic models of dermal absorption

Mccarley, K. D., & Bunge, A. L. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1120 · Cited by 107

The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist? System

Modi, P. J., Mihic, M., & Lewin, A. J. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.208 · Cited by 106

Aminated gelatin microspheres as a nasal delivery system for peptide drugs: Evaluation of in vitro release and in vivo insulin absorption in rats

Wang, J., Tabata, Y., & Morimoto, K. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.03.011 · Cited by 105

Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin

Cui, F. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s26450 · Cited by 103

Molecular Structure of insulin: The insulin monomer and its assembly

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Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release

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Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies

Sintov, A. C., Levy, H. V., & Botner, S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.004 · Cited by 100

Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery

Chono, S., Fukuchi, R., Seki, T., & Morimoto, K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.019 · Cited by 100

Muco-adhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery

Jain, A. K., Chalasani, K. B., Khar, R. K., Ahmed, F. J., & Diwan, P. V. (2007) · Journal of drug targeting · doi:10.1080/10611860701453653 · Cited by 98

Lectin-Based Food Poisoning: A New Mechanism of Protein Toxicity

Miyake, K., Tanaka, T., & McNeil, P. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000687 · Cited by 96

Chondroitin sulfate-capped gold nanoparticles for the oral delivery of insulin

Cho, H., Oh, J., Choo, M.-K., et al. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.10.026 · Cited by 95

Formulation and characterization of an oily-based system for oral delivery of insulin

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Insulin formulations--a review.

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Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice.

Zheng-hongWU, Qi-nengPING, YiWEI, & Jia-mingLAI (2004) · PubMed · Cited by 92

Nasal Insulin Delivery with Dimethyl-β-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations

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Percutaneous absorption and delivery systems33The opinions expressed herein are solely those of the writers and do not necessarily reflect the opinions of the institutions with which the writers are associated.

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Wheat Germ Agglutinin Functionalized Complexation Hydrogels for Oral Insulin Delivery

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Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function

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Formation of poly(glucosyloxyethyl methacrylate)-Concanavalin A complex and its glucose-sensitivity

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Poly(ε-caprolactone)/eudragit nanoparticles for oral delivery of aspart-insulin in the treatment of diabetes

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Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors

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Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis

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Responsive Materials for Self‐ R egulated Insulin Delivery

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Studies on the Mechanism of Bile Salt-Induced Liposomal Membrane Damage

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Intradermal Microneedle Delivery of Insulin Lispro Achieves Faster Insulin Absorption and Insulin Action than Subcutaneous Injection

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Ultrasound‐Triggered Regulation of Blood Glucose Levels Using Injectable Nano‐Network

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Effects of insulin on renal sodium excretion.

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Preparation and evaluation of proliposomes containing salmon calcitonin

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Phenylboronate-diol crosslinked glycopolymeric nanocarriers for insulin delivery at physiological pH

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Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8

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Layer-by-layer deposited nano- and micro-assemblies for insulin delivery: A review

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Oligoarginine-modified biodegradable nanoparticles improve the intestinal absorption of insulin

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Penetratin Derivative-Based Nanocomplexes for Enhanced Intestinal Insulin Delivery

Zhu, X. D., Shan, W., Zhang, P., Jin, Y., Guan, S., Fan, T., Yang, Y., Zhou, Z., & Huang, Y. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400493b · Cited by 78

Amphiphilic glycopolymer nanoparticles as vehicles for nasal delivery of peptides and proteins

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Glucose and pH dual-responsive concanavalin A based microhydrogels for insulin delivery

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Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery

Chuang, E., Lin, K., Su, F.-Y., Chen, H., Maiti, B., Ho, Y., Yen, T., Panda, N., & Sung, H. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.11.011 · Cited by 74

Microneedle-Based Intradermal Versus Subcutaneous Administration of Regular Human Insulin or Insulin Lispro: Pharmacokinetics and Postprandial Glycemic Excursions in Patients with Type 1 Diabetes

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The complexation between novel comb shaped amphiphilic polyallylamine and insulin—Towards oral insulin delivery

Thompson, C. J., Tetley, L., Uchegbu, I. F., & Cheng, W. P. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.04.014 · Cited by 73

A Comparison of the Dynamic Behavior of Monomeric and Dimeric Insulin Shows Structural Rearrangements in the Active Monomer

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pH- and glucose-sensitive glycopolymer nanoparticles based on phenylboronic acid for triggered release of insulin

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Polyamidoamine Dendrimers Can Improve the Pulmonary Absorption of Insulin and Calcitonin in Rats

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Integration of ATP, cAMP, and Ca2+ Signals in Insulin Granule Exocytosis

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Novel Insulin Thiomer Nanoparticles: In Vivo Evaluation of an Oral Drug Delivery System

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Human Insulin

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The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules

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Phenylboronic Acid Grafted Chitosan as a Glucose-Sensitive Vehicle for Controlled Insulin Release

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External control of drug release: controlled release of insulin from a hydrophilic polymer implant by ultrasound irradiation in diabetic rats

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In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion

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Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation

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The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin—Towards oral insulin delivery

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Liposomes as a carrier for oral administration of insulin: Effect of formulation factors

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Multifunctional Polyelectrolyte Microparticles for Oral Insulin Delivery

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Preparation, characterization, and evaluation in vivo of Ins-SiO2-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin

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Lipid emulsions as vehicles for enhanced nasal delivery of insulin

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The Relationship Between the Rigidity of the Liposomal Membrane and the Absorption of Insulin After Nasal Administration of Liposomes Modified with an Enhancer Containing Insulin in Rabbits

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Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats

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Uptake and Transport of Novel Amphiphilic Polyelectrolyte-Insulin Nanocomplexes by Caco-2 Cells—Towards Oral Insulin

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PEGylated insulin Lispro, ( LY2605541 )—a new basal insulin analogue

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Insulin treatment for type 2 diabetes: When to start, which to use

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Aminated gelatin as a nasal absorption enhancer for peptide drugs: evaluation of absorption enhancing effect and nasal mucosa perturbation in rats

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Comparative Immunology of Bovine, Porcine and Human Proinsulins and C-peptides

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Surface Structure of Intestinal Epithelium

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Current status and future prospects of parenteral insulin regimens, strategies and delivery systems for diabetes treatment1Abbreviations: AIA, antiinsulin antibody; CAPD, continuous ambulatory dialysis; CSII, continuous subcutaneous insulin infusion; DCCT, diabetes control complications trial; FIR, far infrared radiation; GLP1, glucagon-like peptide 1; GH, growth hormone; HbA1c, glycated hemoglobin; IDDM, insulin-dependent diabetes mellitus; IGF1, insulin-like growth factor 1; i.p., intraperitoneal; ISF, interstitial fluid; ISGIID, International Study Group on Implantable Insulin Delivery Devices; i.v., intravenous; MDI, multiple daily injections; NIDDM, non-insulin-dependent diabetes mellitus; PAI1, plasminogen activator inhibitor 1; rh IGF1, recombinant human insulin-like growth factor 1; SHBG, sex hormone binding globulin; SC, subcutaneous; SMBG, self monitoring of blood glucose; TG, triglycerides.1

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Intermediate-acting Insulin Preparations: NPH and Lente

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Insulin glulisine: a new rapid-acting insulin analogue for the treatment of diabetes

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Thiomers: development and in vitro evaluation of a peroral microparticulate peptide delivery system

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Novel Biodegradable and pH‐Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery

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