Cited by 1053D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsCancer Cells and Metastasis

A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

Open access
Ruppen, Janine, Cortes-Dericks, Lourdes, Marconi, Emanuele, Karoubi, Golnaz, Schmid, Ralph A., Peng, Renwang, Marti, Thomas M., Guenat, Olivier T.·2014·Lab Chip

Abstract

This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response.

Integrity signals

Registry

Crossref · 10.1039/c3lc51093j

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36 of 36 references verified0 citation errors · 0 not checkable

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Authors
Ruppen, J., Cortes-Dericks, L., Marconi, E., Karoubi, G., Schmid, R. A., Peng, R., Marti, T. M., & Guenat, O. T.
Affiliations
  • University of Bern (CH)
  • Division of General Thoracic Surgery
Corresponding author
Guenat, Olivier T.
Venue
Lab Chip
Published
2014
Volume
14
Issue
6
Pages
1198-1205
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
OpenAlex
W2079761432
Cited by
105
References
36
Citations by year
2025: 5 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 18 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 3
FWCI
6.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Lab on a Chip (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
  • Open Access CRIS of the University of Bern
Funders
  • Novartis Foundation
  • École Polytechnique Fédérale de Lausanne
  • Novartis Stiftung für Medizinisch-Biologische Forschung
  • Bernische Krebsliga
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
malignant pleural mesothelioma, tumor spheroids, chemoresistance, cisplatin, microfluidic perfusion, caspase activity, spheroid viability, drug susceptibility testing, personalized medicine, continuous perfusion
MeSH terms
Drug Screening Assays, Antitumor, Humans, Mesothelioma, Pleural Neoplasms, Spheroids, Cellular, Cell Line, Tumor, Microfluidic Analytical Techniques

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