Challenges of applying multicellular tumor spheroids in preclinical phase

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The extracellular matrix modulates the hallmarks of cancer

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Spherical Cancer Models in Tumor Biology

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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

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High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

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Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

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Solid stress inhibits the growth of multicellular tumor spheroids

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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

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Integrins and Extracellular Matrix in Mechanotransduction

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Biodegradable Polymer Scaffolds with Well-Defined Interconnected Spherical Pore Network

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Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

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Rapid Generation of Single-Tumor Spheroids for High-Throughput Cell Function and Toxicity Analysis

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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside

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Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

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Advances in multicellular spheroids formation

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3D cell culture systems modeling tumor growth determinants in cancer target discovery

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Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

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Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?

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A practical guide for the fabrication of microfluidic devices using glass and silicon

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Three‐dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

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Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing

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3-D Tumor Model forIn VitroEvaluation of Anticancer Drugs

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Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death

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Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment

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Acquired multicellular-mediated resistance to alkylating agents in cancer.

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Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment

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Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression

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Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

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Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells

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Microfluidic self-assembly of tumor spheroids for anticancer drug discovery

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Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

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A review on chitosan centred scaffolds and their applications in tissue engineering

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Modeling neoplastic disease with spheroids and organoids

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A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids

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Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment

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Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <i>In Vivo</i> and Inhibition Enhances Anti-VEGF Therapy

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AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

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Diversity of cell-mediated adhesions in breast cancer spheroids

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Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

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IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage

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Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening

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Pattern of self‐organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model

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High-Content Monitoring of Drug Effects in a 3D Spheroid Model

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Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids

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Generation of Multicellular Breast Cancer Tumor Spheroids: Comparison of Different Protocols

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Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line

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Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations

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Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development

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Comparative analysis of tumor spheroid generation techniques for differentialin vitrodrug toxicity

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Multicellular tumor spheroids as an in vivo-like tumor model for three-dimensional imaging of chemotherapeutic and nano material cellular penetration

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Emerging tumor spheroids technologies for 3D in vitro cancer modeling

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Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research

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Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay

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A software-programmable microfluidic device for automated biology

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Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade – results of an explorative CGH meta-analysis

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Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine

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Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

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Development of an <i>in Vitro</i> 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug

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Media additives to promote spheroid circularity and compactness in hanging drop platform

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Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient

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Laser-based 3D bioprinting for spatial and size control of tumor spheroids and embryoid bodies

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Function of cancer cell-derived extracellular matrix in tumor progression

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