Biological metals and metal-targeting compounds in major neurodegenerative diseases

Barnham, Kevin J., Bush, Ashley I.·2014·Chem. Soc. Rev.

Cites (341)

Items 201–340 of 340

  1. Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-β copper complex follow a preorganization mechanism
    Véronique Balland, Christelle Hureau, Jean‐Michel Savéant · 2010 · Proceedings of the National Academy of Sciences
  2. Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents
    Wei‐Hui Wu, Peng Lei, Qian Rong Liu, Jia Hu, Adam P. Gunn, Mei‐Sha Chen, Yanfang Rui, Xiaoyang Su, Zuoping Xie, Yufen Zhao et al. · 2008 · Journal of Biological Chemistry
  3. Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson?s disease and other neurodegenerative diseases
    Youdim, M. B. H., Fridkin, M., Zheng, H. · 2004 · Journal of Neural Transmission
  4. Histological Co-Localization of Iron in A� Plaques of PS/APP Transgenic Mice
    Maria Fatima Falangola, Phil Lee, Ralph A. Nixon, Karen Duff, Joseph A. Helpern · 2005 · Neurochemical Research
  5. Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease
    Javier Becerril-Ortega, Karim Bordji, Thomas Fréret, Travis Rush, Alain Buisson · 2014 · Neurobiology of Aging
  6. Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β Peptides
    Jeppe T. Pedersen, Jesper Østergaard, Noémi Rozlosnik, Bente Gammelgaard, Niels H. H. Heegaard · 2011 · Journal of Biological Chemistry
  7. Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (<i>HFE</i>) as risk factors for developing Alzheimer’s disease
    Robson, K J H, Lehmann, D J, Wimhurst, V L C, Livesey, K J, Combrinck, M, Merryweather-Clarke, A T, Warden, D R, Smith, A D · 2004 · Journal of Medical Genetics
  8. Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease
    Paul Anthony Adlard, Laura Bica, Anthony Robert White, Milawaty Nurjono, Gulay Filiz, Peter John Crouch, Paul S. Donnelly, Roberto Cappai, David Isaac Finkelstein, Ashley Ian Bush · 2011 · PLoS ONE
  9. Copper binding regulates intracellular alpha‐synuclein localisation, aggregation and toxicity
    Xiaoyan Wang, Dima Moualla, Josephine A. Wright, David R. Brown · 2010 · Journal of Neurochemistry
  10. Growth Inhibitory Factor Prevents Neurite Extension and the Death of Cortical Neurons Caused by High Oxygen Exposure through Hydroxyl Radical Scavenging
    Yoko Uchida, Fujiya Gomi, Toshiki Masumizu, Yuri Miura · 2002 · Journal of Biological Chemistry
  11. Zinc-specific Autometallographic In Vivo Selenium Methods: Tracing of Zinc-enriched (ZEN) Terminals, ZEN Pathways, and Pools of Zinc Ions in a Multitude of Other ZEN Cells
    Gorm Danscher, Meredin Stoltenberg · 2005 · Journal of Histochemistry & Cytochemistry
  12. Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration
    Christopher J. Frederickson, Leonard J. Giblin, Balaji Rengarajan, Rafik Masalha, C.J. Frederickson, Yaping Zeng, Emilio Varea, Jae‐Young Koh, Udi Chorin, Limor Besser et al. · 2006 · Journal of Neuroscience Methods
  13. Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency
    Meredin Stoltenberg, Ashley Ian Bush, Georg Bach, K. Smidt, Agnete Larsen, Jørgen Rungby, Sten A. Lund, Peter Doering, Gorm Danscher · 2007 · Neuroscience
  14. An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
    Dominic James Hare, Peng Lei, Scott Ayton, Blaine Russell Roberts, Rudolf Grimm, Jessica L. George, David Bishop, Alison D. Beavis, Sarah J. Donovan, Gawain McColl et al. · 2014 · Chemical Science
  15. sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin
    Ryan C. McCarthy, Yun‐Hee Park, Daniel J. Kosman · 2014 · EMBO Reports
  16. Werner coordination chemistry and neurodegeneration
    Maria A. Telpoukhovskaia, Chris Orvig · 2012 · Chemical Society Reviews
  17. A Laser Microprobe Mass Analysis of Brain Aluminum and Iron in Dementia pugilistica: Comparison with Alzheimer's Disease
    Constantin Bouras, Pantéleimon Giannakopoulos, Paul F. Good, Amy Hsu, Patrick R. Hof, Daniel P. Perl · 2007 · European Neurology
  18. Redox Processes of Methionine Relevant to β-Amyloid Oxidation and Alzheimer's Disease
    Christian Schöneich · 2002 · Archives of Biochemistry and Biophysics
  19. Combating Alzheimer's Disease With Multifunctional Molecules Designed for Metal Passivation
    Harvey J. Schugar, David E. Green, Meryn L. Bowen, Lauren E. Scott, Tim Storr, Karin Böhmerle, Fancy C. Thomas, David D. Allen, Paul R. Lockman, Michael Merkel et al. · 2007 · Angewandte Chemie International Edition
  20. Copper- and iron-induced differential fibril formation in α-synuclein: TEM study
    Bharathi ..., Shantinath Satappa Indi, K. S. Jagannatha Rao · 2007 · Neuroscience Letters
  21. Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain
    Sven O. Dahms, Ina Könnig, Dirk Roeser, Karl‐Heinz Gührs, Magnus Mayer, Daniela Kaden, Gerd Multhaup, Manuel E. Than · 2012 · Journal of Molecular Biology
  22. SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status
    Yuewei Sheng, Madhuri Chattopadhyay, Julian P. Whitelegge, Joan Selverstone Valentine · 2013 · Current Topics in Medicinal Chemistry
  23. Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease
    Rosanna Squitti, Roberta Ghidoni, Mariacristina Siotto, Mariacarla Ventriglia, Luisa Benussi, Anna Paterlini, Mariachiara Magri, Giuliano Gb. Binetti, Emanuele Cassetta, Deborah Caprara et al. · 2014 · Annals of Neurology
  24. Neurorescue Activity, APP Regulation and Amyloid-β Peptide Reduction by Novel Multi-Functional Brain Permeable Iron- Chelating- Antioxidants,M-30 and Green Tea Polyphenol, EGCG
    Yael Avramovich‐Tirosh, Lydia Reznichenko, Tamar Amit, Hailin Zheng, Mati Fridkin, Orly Weinreb, Silvia A. Mandel, Moussa B. H. Youdim · 2007 · Current Alzheimer Research
  25. Copper Modulation of NMDA Responses in Mouse and Rat Cultured Hippocampal Neurons
    Viktorie Vlachová, Hana W. Zemkova, Ladislav Vyklický · 1996 · European Journal of Neuroscience
  26. Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging
    George Bartzokis, Po H. Lu, Kathleen Tingus, Douglas G. Peters, Chetan P. Amar, Todd A. Tishler, J. Paul Finn, Pablo J. Villablanca, Lori L. Altshuler, Jim Mintz et al. · 2011 · Neuropsychopharmacology
  27. Copper Promotes the Trafficking of the Amyloid Precursor Protein
    Karla M. Acevedo, Ya Hui Hung, Andrew H. Dalziel, Qiao‐Xin Li, Katrina M. Laughton, Krutika Wikhe, Alan Rembach, Blaine Russell Roberts, Colin Louis Masters, Ashley Ian Bush et al. · 2010 · Journal of Biological Chemistry
  28. Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS
    Gerald Goodall, M. J. Greenway, Ingrid van Marion, Camille Carroll, Orla M. Hardiman, Karen E. Morrison · 2005 · Neurology
  29. Metal binding sites in amyloid oligomers: Complexes and mechanisms
    Yifat Miller, Buyong Ma, Ruth Nussinov · 2012 · Coordination Chemistry Reviews
  30. Alterations of Zinc Transporter Proteins ZnT‐1, ZnT‐4 and ZnT‐6 in Preclinical Alzheimer's Disease Brain
    Ganna Lyubartseva A, Jennifer L. Smith, William R. Markesbery, Mark A. Lovell · 2009 · Brain Pathology
  31. Biophysical Studies of the Amyloid β‐Peptide: Interactions with Metal Ions and Small Molecules
    Sebastian K.T.S. Wärmländer, Ann Tiiman, Axel Abelein, Jinghui Luo, Jüri Jarvet, Kajsa Löfgren Söderberg, Jens Danielsson, Astrid Gräslund · 2013 · ChemBioChem
  32. Copper prevents amyloid-β1–42 from forming amyloid fibrils under near-physiological conditions in vitro
    Mold, Matthew, Ouro-Gnao, Larissa, Wieckowski, Beata M, Exley, Christopher · 2013 · Scientific Reports
  33. Total Iron-binding Capacity Calculated from Serum Transferrin Concentration or Serum Iron Concentration and Unsaturated Iron-binding Capacity
    Hachiro Yamanishi, Shigeru Iyama, Yoshihisa Yamaguchi, Yuzuru Kanakura, Yoshinori Iwatani · 2003 · Clinical Chemistry
  34. Gene knockout of amyloid precursor protein and amyloid precursor‐like protein‐2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Shayne A. Bellingham, Giuseppe D. Ciccotosto, B. Elise Needham, Lisa R. Fodero, Anthony Robert White, Colin Louis Masters, Roberto Cappai, James Camakaris · 2004 · Journal of Neurochemistry
  35. A role for zinc in postsynaptic density asSAMbly and plasticity?
    Gundelfinger, Eckart D., Boeckers, Tobias M., Baron, Marisa K., Bowie, James U. · 2006 · Trends in Biochemical Sciences
  36. Estrogen Decreases Zinc Transporter 3 Expression and Synaptic Vesicle Zinc Levels in Mouse Brain
    Joo‐Yong Lee, Jung-Hwan Kim, Seok Ho Hong, Ji Yoon Lee, Robert A. Cherny, Ashley Ian Bush, Richard D. Palmiter, Jae‐Young Koh · 2004 · Journal of Biological Chemistry
  37. Intake of copper has no effect on cognition in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial
    Holger Kessler, Thomas A. Bayer, Daniela Bach, Thomas Schneider-Axmann, Tillmann Supprian, Wolfgang Herrmann, Manfred Haber, Gerd Multhaup, Peter Falkai, Frank–Gerald Pajonk · 2008 · Journal of Neural Transmission
  38. Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
    Bjorklund, Nicole L, Reese, Lindsay C, Sadagoparamanujam, V-M, Ghirardi, Valeria, Woltjer, Randall L, Taglialatela, Giulio · 2012 · Molecular Neurodegeneration
  39. Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer β-amyloid pathology
    Christa J. Maynard, Roberto Cappai, Irene Volitakis, Robert A. Cherny, Colin Louis Masters, Qiao‐Xin Li, Ashley Ian Bush · 2006 · Journal of Inorganic Biochemistry
  40. The effects of copper ions on glutamate receptors in cultured rat cortical neurons
    Thomas W. Weiser, M. Wienrich · 1996 · Brain Research
  41. Interactions between Amyloid-β and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease
    Jia‐Ying Chuang, Chu-Wan Lee, Yao‐Hsiang Shih, Tingting Yang, Lung Yu, Yu‐Min Kuo · 2012 · PLoS ONE
  42. Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage alzheimer’s disease
    Mark A. Lovell, Jennifer L. Smith, Shuling Xiong, William R. Markesbery · 2005 · Neurotoxicity Research
  43. α-Synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies
    Manuela Neumann, Silke Adler, Oliver M. Schlüter, Elisabeth Kremmer, R. Benecke, Hans A. Kretzschmar · 2000 · Acta Neuropathologica
  44. Copper catalyzed oxidation of Alzheimer Abeta.
    Craig S. Atwood, Xudong Huang, Ashok Khatri, R C Scarpa, Y S Kim, Robert D. Moir, Rudolph E. Tanzi, Alex E. Roher, Ashley Ian Bush · 2000 · PubMed
  45. Role of spermine in amyloid ?-peptide-associated free radical-induced neurotoxicity
    Servet M. Yatin, Mustafa Yatin, Sridhar Varadarajan, Kenneth B. Ain, David Allan Butterfield · 2001 · Journal of Neuroscience Research
  46. Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis
    Erin J. McAllum, Nastasia K.-H. Lim, James L. Hickey, Brett M. Paterson, Paul S. Donnelly, Qiao-Xin Li, Jeffrey R. Liddell, Kevin Jeffrey Barnham, Anthony Robert White, Peter John Crouch · 2013 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  47. Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species
    Joseph J. Braymer, Jung-Suk Choi, Alaina S. DeToma, Chen Wang, Kisoo Nam, Jeffrey W. Kampf, Ayyalusamy Ramamoorthy, Mi Hee Lim · 2011 · Inorganic Chemistry
  48. Functional relevance of ceruloplasmin mutations in Parkinson's Disease
    Hochstrasser, Helmine, Tomiuk, Jürgen, Walter, Uwe, Behnke, Stefanie, Spiegel, Jörg, Krüger, Rejko, Becker, Georg, Riess, Olaf, Berg, Daniela · 2005 · The FASEB Journal
  49. Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms
    Michael A. Cater, Kelly T. McInnes, Qiao‐Xin Li, Irene Volitakis, Sharon La Fontaine, Julian F. B. Mercer, Ashley Ian Bush · 2008 · Biochemical Journal
  50. The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease
    Lana Kupershmidt, Tamar Amit, Orit Bar‐Am, Moussa B. H. Youdim, Orly Weinreb · 2012 · Antioxidants and Redox Signaling
  51. A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys
    Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L. et al. · 2010 · Journal of Neuroscience
  52. Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor
    Claudio Acuña‐Castillo, Claudio Coddou, Paulina Bull, Jocelyn Brito-Echeverría, Juan Pablo Huidobro-Toro · 2007 · Journal of Neurochemistry
  53. Bis (thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease
    Michelle T. Fodero‐Tavoletti, Victor L. Villemagne, Brett M. Paterson, Anthony Robert White, Qiao‐Xin Li, James Camakaris, Graeme Joseph O'Keefe, Roberto Cappai, Kevin Jeffrey Barnham, Paul S. Donnelly · 2010 · Journal of Alzheimer s Disease
  54. The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice
    Seiichi Nagano, Yuuichi Fujii, Takeshi Yamamoto, Mitsue Taniyama, Kei Fukada, Takehiko Yanagihara, Saburo Sakoda · 2003 · Experimental Neurology
  55. Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities
    Eiichi Tokuda, Eriko Okawa, Shunsuke Watanabe, Shin-ichi Ono, Stefan L. Marklund · 2013 · Neurobiology of Disease
  56. ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis
    Rajaâ El Meskini, Kelli L. Crabtree, Laura B. Cline, Richard E. Mains, Betty A. Eipper, Gabriele V. Ronnett · 2007 · Molecular and Cellular Neuroscience
  57. The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen
    Jack T. Rogers, Sohan Mikkilineni, Ippolita Cantuti‐Castelvetri, Deborah H. Smith, Xudong Huang, Sanghamitra Bandyopadhyay, Catherine M. Cahill, Maria L. Maccecchini, Debomoy K. Lahiri, Nigel H. Greig · 2011 · Journal of Neural Transmission
  58. Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice
    Seiichi Nagano, Yasuko Ogawa, Takehiko Yanagihara, Saburo Sakoda · 1999 · Neuroscience Letters
  59. Synaptic Zn2+Inhibits Neurotransmitter Release by Promoting Endocannabinoid Synthesis
    Tamara Perez‐Rosello, Charles T. Anderson, Francisco Jose Schopfer, Yanjun Zhao, David Gilad, Sonia R. Salvatore, Bruce Α. Freeman, Michal Hershfinkel, Elias Aizenman, Thanos Tzounopoulos · 2013 · Journal of Neuroscience
  60. Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy
    Evandro Ferrada, Veróníca Arancibia, Bárbara Loeb L., Ester Norambuena, Claudio Olea‐Azar, Juan Pablo Huidobro-Toro · 2007 · NeuroToxicology
  61. Zinc Deficiency Is Associated with Increased Brain Zinc Import and LIV-1 Expression and Decreased ZnT-1 Expression in Neonatal Rats
    Winyoo Chowanadisai, Shannon L. Kelleher, Bo L Lönnerdal · 2005 · Journal of Nutrition
  62. Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation
    Ângela C. Crespo, Bruno Dias Rodrigues Silva, Liliana Marques, Erica Marcelino, Carolina Maruta, Sónia Costa, Ângela Timóteo, Arminda Vilares, Frederico Simões do Couto, Paula Faustino et al. · 2013 · Neurobiology of Aging
  63. Elevated Serum Ferritin Is Associated with Reduced Survival in Amyotrophic Lateral Sclerosis
    Yann Nadjar, Paul Gordon, Philippe Corcia, Gilbert Bensimon, Laurence Piéroni, Vincent Meininger, François Salachas · 2012 · PLoS ONE
  64. Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms
    Daniel F. Tardiff, Michelle L. Tucci, Kim A. Caldwell, Guy A. Caldwell, Susan Lee Lindquist · 2011 · Journal of Biological Chemistry
  65. Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone
    Yulia Pushkar, Gregory Robison, Brendan Sullivan, Sherleen X. Fu, Meghan Kohne, Wendy Jiang, Sven Olaf Rohr, Barry Chi Hong Lai, Matthew A. Marcus, Taisiya Zakharova et al. · 2013 · Aging Cell
  66. PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease
    Robert A. Cherny, Scott Ayton, David Isaac Finkelstein, Ashley Ian Bush, Gawain McColl, Stephen M. Massa · 2012 · Journal of Huntington s Disease
  67. A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis‐linked SOD1 mutants
    Takao Fujisawa, Kengo Homma, Namiko Yamaguchi, Hisae Kadowaki, Naomi Tsuburaya, Isao Naguro, Atsushi Matsuzawa, Kohsuke Takeda, Yuji Takahashi, Jun Goto et al. · 2012 · Annals of Neurology
  68. Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease
    Marco Miotto, Esaú E. Rodríguez, Ariel A. Valiente‐Gabioud, Valentina Torres Monserrat, Andrés Binolfi, Liliana Quintanar, Markus Zweckstetter, Christian Griesinger, Claudio O. Fernández · 2014 · Inorganic Chemistry
  69. Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
    Andreas Martin Grabrucker, Michael J. Schmeißer, Patrick T. Udvardi, Magali H. Arons, Michael Schoen, Nathaniel S. Woodling, Katrin I. Andreasson, Patrick R. Hof, Joseph D. Buxbaum, Craig Curtis Garner et al. · 2011 · Molecular Neurodegeneration
  70. Biphasic effects of copper on neurotransmission in rat hippocampal neurons
    Christian Peters, Braulio Muñoz, Fernando J. Sepúlveda, Juan C. Urrutia, Mauricio Quiroz, Sandra Luza, Giancarlo V De Ferrari, Luis Gerardo Aguayo, Carlos Opazo · 2011 · Journal of Neurochemistry
  71. Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis
    Eiichi Tokuda, Shin-ichi Ono, Kumiko Ishige, Akira Naganuma, Yoshihisa Ito, Takashi Suzuki · 2006 · Toxicology
  72. Red cell perturbations by amyloid β-protein
    Jayakumar Rajadas, John W. Kusiak, Francis J. Chrest, Afolorunso Andrew Demehin, Murali Jayaraman, Robert P. Wersto, Enika Nagababu, Luke B. Ravi, Joseph Moses Rifkind · 2003 · Biochimica et Biophysica Acta (BBA) - General Subjects
  73. Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity
    Mark A. Greenough, Irene Volitakis, Qiao‐Xin Li, Katrina M. Laughton, Genevieve M. Evin, Michael Ho, Andrew H. Dalziel, James Camakaris, Ashley Ian Bush · 2011 · Journal of Biological Chemistry
  74. Copper and Heme-Mediated Abeta Toxicity: Redox Chemistry, Abeta Oxidations and Anti-ROS Compounds
    Stefan Chassaing, Fabrice Collin, Pierre Dorlet, Jérôme Gout, Christelle Hureau, Peter Faller · 2013 · Current Topics in Medicinal Chemistry
  75. Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis
    Eiichi Tokuda, Shin-ichi Ono, Kumiko Ishige, Shunsuke Watanabe, Eriko Okawa, Yoshihisa Ito, Takashi Suzuki · 2008 · Experimental Neurology
  76. Iron deposits in post‐mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi‐quantitative 7.0 T magnetic resonance imaging study
    Jacques L. De Reuck, Vincent Deramecourt, F. Auger, Nicolas Durieux, Charlotte Cordonnier, David Devos, Luc Defebvre, Caroline Moreau, Dominique Caparros-Lefebvre, Didier Leys et al. · 2014 · European Journal of Neurology
  77. Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
    Katherine J. Schweitzer, Theresa Brüssel, Petra Leitner, Rejko Krüger, Peter Bauer, Dirk Woitalla, Jürgen Tomiuk, Thomas Gasser, Daniela Berg · 2007 · Journal of Neurology
  78. Blood-Borne Amyloid-β Dimer Correlates with Clinical Markers of Alzheimer's Disease
    Victor L. Villemagne, Keyla A. Perez, Kerryn Elizabeth Pike, Woan Mei Kok, Christopher Cleon Rowe, Anthony Robert White, Pierrick Bourgeat, Olivier Salvado, Justin Bedő, Craig A. Hutton et al. · 2010 · Journal of Neuroscience
  79. Convergent Ca 2+ and Zn 2+ signaling regulates apoptotic Kv2.1 K + currents
    Meghan C. McCord, Elias Aizenman · 2013 · Proceedings of the National Academy of Sciences
  80. Quantitative assessment of subcortical atrophy and iron content in progressive supranuclear palsy and parkinsonian variant of multiple system atrophy
    Jae‐Hyeok Lee, Yong-Hee Han, Bok‐Man Kang, Chi‐Woong Mun, Sangjae Lee, Seung Kug Baik · 2013 · Journal of Neurology
  81. Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level
    Georg Nübling, Benedikt Bader, Johannes Levin, Jenna Hildebrandt, Hans A. Kretzschmar, Armin Giese · 2012 · Molecular Neurodegeneration
  82. Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles
    J. Hagenah, Inke Regina König, Björn Becker, R. Hilker, Meike Kasten, Katja Hedrich, Peter Paul Pramstaller, Christine Klein, Günter Seidel · 2007 · Journal of Neurology
  83. Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein
    Jonathan H. Fox, Teal Connor, Megan A. Stiles, Jibrin A. Kama, Zhen Lü, Kathryn Dorsey, Gregory Liebermann, Ellen Sapp, Robert A. Cherny, Mary Banks et al. · 2011 · Journal of Biological Chemistry
  84. Intracellular zinc inhibits KCC2 transporter activity
    Michal Hershfinkel, Karl Kandler, Megan E. Knoch, Michal Dagan-Rabin, Mandar A. Aras, Chen Abramovitch‐Dahan, Israel Sekler, Elias Aizenman · 2009 · Nature Neuroscience
  85. Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease
    Federica Giambattistelli, Serena Bucossi, Carlo Salustri, Valentina Panetta, Stefania Mariani, Mariacristina Siotto, Mariacarla Ventriglia, Fabrizio Vernieri, Maria Luisa Dell’Acqua, Emanuele Cassetta et al. · 2011 · Neurobiology of Aging
  86. Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model
    Fabia Febbraro, Kathrine Just Andersen, Vanesa Sánchez-Guajardo, Noémie Tentillier, Marina Romero‐Ramos · 2013 · Experimental Neurology
  87. Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions
    Ya Hui Hung, Elysia L. Robb, Irene Volitakis, Michael Ho, Genevieve M. Evin, Qiao-Xin Li, Janetta Gladys Culvenor, Colin Louis Masters, Robert A. Cherny, Ashley Ian Bush · 2009 · Journal of Biological Chemistry
  88. The Elevated Copper Binding Strength of Amyloid-β Aggregates Allows the Sequestration of Copper from Albumin: A Pathway to Accumulation of Copper in Senile Plaques
    Dianlu Jiang, Lin Zhang, Gian Paola G. Grant, Christopher G. Dudzik, Shu Chen, Sveti Patel, Yuanqiang Hao, Glenn L. Millhauser, Feimeng Zhou · 2012 · Biochemistry
  89. Free radical theory of aging: A hypothesis on pathogenesis of senile dementia of the Alzheimer’s type
    Denham Harman · 1993 · AGE
  90. Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands
    Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M. Laughton, Irene Volitakis, Robyn A. Sharples, Robert A. Cherny, Colin Louis Masters, Simon C. Drew, Andrew Francis Hill et al. · 2007 · Biochemical Journal
  91. Clioquinol Reduces Zinc Accumulation in Neuritic Plaques and Inhibits the Amyloidogenic Pathway in AβPP/PS1 Transgenic Mouse Brain
    Tao Wang, Chunyan Wang, Zhongyan Shan, Weiping Teng, Zhan‐You Wang · 2012 · Journal of Alzheimer s Disease
  92. Single particle analysis of tau oligomer formation induced by metal ions and organic solvents
    Benedikt Bader, Georg Nübling, Anja Mehle, Simona Nobile, Hans A. Kretzschmar, Armin Giese · 2011 · Biochemical and Biophysical Research Communications
  93. Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease
    Minglin Lang, Lei Wang, Qiangwang Fan, Guiran Xiao, Xiaoxi Wang, Yi Zhong, Bing Zhou · 2012 · PLoS Genetics
  94. Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in aDrosophilamodel by tight control of zinc and copper availability
    Haiqing Hua, Lisa Marie Munter, Anja Harmeier, Oleg Georgiev, Gerd Multhaup, Walter Schaffner · 2011 · Biological Chemistry
  95. The Second Cu(II)-Binding Site in a Proton-Rich Environment Interferes with the Aggregation of Amyloid-β(1−40) into Amyloid Fibrils
    Sangmi Jun, Joel R. Gillespie, Byong‐kyu Shin, Sunil Saxena · 2009 · Biochemistry
  96. Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques
    Meredin Stoltenberg, Mikkel Bruhn, Christian Skou Søndergaard, Peter Doering, Mark J. West, Agnete Larsen, Juan Carlos Troncoso, Gorm Danscher · 2005 · Histochemistry and Cell Biology
  97. The lipophilic metal chelators DP‐109 and DP‐460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis
    Petri, Susanne, Calingasan, Noel Y., Alsaied, Osama A., Wille, Elizabeth, Kiaei, Mahmoud, Friedman, Jonathan E., Baranova, Oxana, Chavez, Juan C., Beal, M. Flint · 2007 · Journal of Neurochemistry
  98. New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals: An ESR study using a series of spin-traps
    Stuart Turnbull, Brian J. Tabner, Omar M. A. El‐Agnaf, Lance J. Twyman, David Allsop · 2001 · Free Radical Biology and Medicine
  99. Concentrations of zinc and iron in the brains of Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia.
    Masayuki YASUI, Kiichiro OTA, Ralph M. Garruto · 1993 · PubMed
  100. Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations
    J. Hagenah, Björn Becker, Norbert Brüggemann, Ana Djarmati, Katja Lohmann, Andreas Sprenger, Christine Klein, Günter Seidel · 2008 · Journal of Neurology Neurosurgery & Psychiatry
  101. Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker
    Sanneke van Rooden, Maarten J. Versluis, Michael K. Liem, Julien Milles, Andrea Britta Maier, Ania M. Oleksik, ANDREW G. WEBB, Mark A. van Buchem, Jeroen van der Grond · 2013 · Alzheimer s & Dementia
  102. Structural Basis of NR2B-Selective Antagonist Recognition by N-Methyl-d-aspartate Receptors
    Laétitia Mony, Lucie Krzaczkowski, Manuel D. Leonetti, Anne Le Goff, Karine Alarcon, Jacques Neyton, Hughes-Olivier Bertrand, Francine Acher, Pierre Paoletti · 2008 · Molecular Pharmacology
  103. Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis
    Shohei Watanabe, Seiichi Nagano, James A. Duce, Mahmoud Kiaei, Qiao-Xin Li, Stephanie M. Tucker, Ashutosh Tiwari, Robert H. Brown, M. Flint Beal, Lawrence J. Hayward et al. · 2007 · Free Radical Biology and Medicine
  104. Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease
    Alan Rembach, James D. Doecke, Blaine Russell Roberts, Andrew D. Watt, Noel Garry Faux, Irene Volitakis, Kelly Kathleen Pertile, Rebecca L. Rumble, Brett O. Trounson, Christopher James Fowler et al. · 2013 · Journal of Alzheimer s Disease
  105. Recent Development of Bifunctional Small Molecules to Study Metal‐Amyloid‐<i>β</i> Species in Alzheimer′s Disease
    Braymer, Joseph J., DeToma, Alaina S., Choi, Jung-Suk, Ko, Kristin S., Lim, Mi Hee · 2011 · International Journal of Alzheimer’s Disease
  106. Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
    Mahmoud Kiaei, Ashley Ian Bush, Brett M. Morrison, John H. Morrison, Robert A. Cherny, Irene Volitakis, M. Flint Beal, Jon W. Gordon · 2004 · Journal of Neuroscience
  107. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease–like symptoms
    Minglin Lang, Qiangwang Fan, Lei Wang, Yajun Zheng, Guiran Xiao, Xiaoxi Wang, Wei Wang, Yi Zhong, Bing Zhou · 2013 · Neurobiology of Aging
  108. Interaction of amyloid β peptides with redox active heme cofactor: Relevance to Alzheimer's disease
    Debajyoti Pramanik, Chandradeep Ghosh, Soumya Mukherjee, Somdatta Ghosh Dey · 2012 · Coordination Chemistry Reviews
  109. Amyloid β and neuromelanin—Toxic or protective molecules?The cellular context makes the difference
    K. S. Jagannatha Rao, Muralidhar L. Hegde, S. Anitha, Massimo Musicco, Fabio Andrea Zucca, N. J. TURRO, Luigi Zecca · 2006 · Progress in Neurobiology
  110. Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells
    Karla M. Acevedo, Carlos Opazo, David Norrish, Leesa M. Challis, Qiao‐Xin Li, Anthony Robert White, Ashley Ian Bush, James Camakaris · 2014 · Journal of Biological Chemistry
  111. Motor phenotype and magnetic resonance measures of basal ganglia iron levels in Parkinson's disease
    Nico Bunzeck, Victoria Singh‐Curry, Cindy Eckart, Nikolaus Weiskopf, Richard J. Perry, Peter G. Bain, Emrah Düzel, Masud Husain B · 2013 · Parkinsonism & Related Disorders
  112. Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis
    Toni Ahtoniemi, Gundars Goldsteins, Velta Keksa-Goldsteine, Tarja Malm, Katja M. Kanninen, Antero Salminen, Jari Koıstınaho · 2006 · Molecular Pharmacology
  113. Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation
    Ramón A. Lorca, Claudio Coddou, María Consuelo Gazitúa, Paulina Bull, Cristián Arredondo, Juan Pablo Huidobro-Toro · 2005 · Journal of Neurochemistry
  114. ALS-Causing SOD1 Mutations Promote Production of Copper-Deficient Misfolded Species
    Philbert Ip, Vikram Khipple Mulligan, Avijit Chakrabartty · 2011 · Journal of Molecular Biology
  115. Neuroferritinopathy
    John Burn, Patrick Francis Chinnery · 2006 · Seminars in Pediatric Neurology
  116. Alpha‐synuclein and its role in metal binding: Relevance to Parkinson's disease
    Josephine A. Wright, David R. Brown · 2007 · Journal of Neuroscience Research
  117. Cognitive decline due to excess synaptic Zn2+ signaling in the hippocampus
    Atsushi Takeda, Haruna Tamano · 2014 · Frontiers in Aging Neuroscience
  118. Overexpression of Aβ is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model
    Qiao‐Xin Li, Su San Mok, Katrina M. Laughton, Catriona McLean, Irene Volitakis, Robert A. Cherny, Nam Sang Cheung, Anthony Robert White, Colin Louis Masters · 2006 · Aging Cell
  119. Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice
    Lana Kupershmidt, Tamar Amit, Orit Bar‐Am, Orly Weinreb, Moussa B. H. Youdim · 2012 · Molecular Neurobiology
  120. Zn2+-Aβ40 Complexes Form Metastable Quasi-spherical Oligomers That Are Cytotoxic to Cultured Hippocampal Neurons
    Inna Solomonov, Eduard Korkotian, Benjamin Born, Yishay Feldman, Arkady Bitler, Farid Rahimi, Huiyuan Li, Gal Bitan, Irit Sagi · 2012 · Journal of Biological Chemistry
  121. Transcranial ultrasound as a risk marker for Parkinson's disease
    Daniela Berg · 2009 · Movement Disorders
  122. Substantia nigra hyperechogenicity with LRRK2 G2019S mutations
    Norbert Brüggemann, Johann M. Hagenah, Kaili Maloy Stanley, Christine Klein, Cuiling Wang, Deborah Raymond, Laurie J. Ozelius, Susan Bressman, Rachel J. Saunders-Pullman · 2011 · Movement Disorders
  123. Inhibition of Cu‐Amyloid‐β by using Bifunctional Peptides with β‐Sheet Breaker and Chelator Moieties
    Madeleine Jensen, Anne Canning, Sabri Chiha, Pierre Bouquerel, Jeppe T. Pedersen, Jesper Østergaard, Olivier Cuvillier, Isabelle Sasaki, Christelle Hureau, Peter Faller · 2012 · Chemistry - A European Journal
  124. The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase‐3
    A. Gerard Daniel, Erica J. Peterson, Nicholas P. Farrell · 2014 · Angewandte Chemie International Edition
  125. Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production
    Emma H. Gray, Kurt J. De Vos, Colin Dingwall, Michael S. Perkinton, Christopher C.J. Miller · 2010 · Journal of Alzheimer s Disease
  126. Efficacy and Toxicity of Clioquinol Treatment and A-beta42 Inoculation in the APP/PSI Mouse Model of Alzheimer’s Disease
    Yi-Hong Zhang, James B. Raymick, Sumit Sarkar, Debomoy K. Lahiri, Balmiki Ray, David M. Holtzman, Melanie Dumas, Larry C. Schmued · 2013 · Current Alzheimer Research
  127. CCS knockout mice establish an alternative source of copper for SOD in ALS
    Joseph S. Beckman, Álvaro G. Estévez, Luis Barbeito, John P. Crow · 2002 · Free Radical Biology and Medicine
  128. High precision isotope measurements reveal poor control of copper metabolism in Parkinsonism
    Fiona Larner, Barry Sampson, Mark Rehkämper, Dominik Jakob Weiss, Jack R. Dainty, Saidhbhe L. O’Riordan, T. Panetta, P. G. Bain · 2013 · Metallomics
  129. Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?
    Ashley Ian Bush · 2002 · Nature Neuroscience
  130. Imbalance of iron influx and efflux causes brain iron accumulation over time in the healthy adult rat
    Jie‐Hua Chen, Nadia Nur Singh, Huimin Tay, Thomas Walczyk · 2014 · Metallomics
  131. Formation of carnosine‐Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors
    Claudio Coddou, Claudio A. Villalobos, Jorge González, Claudio Acuña‐Castillo, Bárbara Loeb L., Juan Pablo Huidobro-Toro · 2002 · Journal of Neurochemistry
  132. Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors
    Claudio Coddou, Bernardo Morales, Juan Pablo Huidobro-Toro · 2003 · European Journal of Pharmacology
  133. Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis
    B. Elise Needham, Giuseppe D. Ciccotosto, Roberto Cappai · 2014 · Metallomics
  134. 4-Hydroxynonenal disrupts zinc export in primary rat cortical cells
    J SMITH, Shuling Xiong, Mark A. Lovell · 2005 · NeuroToxicology
  135. Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease
    Manas Seal, Soumya Mukherjee, Debajyoti Pramanik, Kaustuv Mittra, Abhishek Dey, Somdatta Ghosh Dey · 2012 · Chemical Communications
  136. Monomerized Cu,Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding
    Hitoshi Kishigami, Seiichi Nagano, Ashley Ian Bush, Saburo Sakoda · 2010 · Free Radical Biology and Medicine
  137. Effects of copper on A-type potassium currents in acutely dissociated rat hippocampal CA1 neurons
    Zhi-Dian Niu, Kuai Yu, Yan Gu, Ming Wang, Jiaqi She, Weiheng Chen, Di‐Yun Ruan · 2005 · Neuroreport
  138. Inhibition of delayed rectifier K+ currents by copper in acutely dissociated rat hippocampal CA1 neurons
    Zhaorui Niu, J CHEN, Szu‐Han Wang, M WANG, X LI, D RUAN · 2006 · Toxicology Letters
  139. Errata
    2009 · The Lancet Neurology
  140. Diet and Alzheimer's disease: meeting the challenges.
    Martha Clare Morris · 2006 · PubMed