A role for zinc in postsynaptic density asSAMbly and plasticity?
Abstract
Chemical synapses are asymmetric cell junctions that mediate communication between neurons. Multidomain scaffolding proteins of the Shank family act as major organizing elements of the "postsynaptic density"--that is, the cytoskeletal protein matrix associated with the postsynaptic membrane. A recent study has shown that the C-terminal sterile alpha-motif or "SAM domain" of Shank3 (also known as ProSAP2) can form two-dimensional sheets of helical fibers. Assembly and packaging of these fibers are markedly enhanced by the presence of Zn2+ ions. Zn2+ can be released together with glutamate from synaptic vesicles and can enter the postsynaptic cell through specific ionotropic receptors. Based on these observations, we propose a new model of synaptic plasticity in which Zn2+ influx directly and instantly modulates the structure and function of the postsynaptic density.
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Shank1, Shank2, and Shank3 are synaptic scaffolding proteins that assemble a large protein complex at the postsynaptic density of excitatory glutamatergic synapses.
“Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that organize an extensive protein complex at the postsynaptic density (PSD) of excitatory glutamatergic synapses.”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Gundelfinger et al., 2006
Shank family proteins are scaffolding proteins that organize a cytoskeleton-associated signaling complex at the postsynaptic density of nearly all excitatory glutamatergic synapses in the mammalian brain.
“Shank family proteins are scaffolding proteins that organize a cytoskeleton-associated signaling complex at the postsynaptic density (PSD) of nearly all excitatory glutamatergic synapses in the mammalian brain (Grabrucker et al., 2011b; Gundelfinger et al., 2006; Kreienkamp, 2008; Sheng and Kim, 2000).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Gundelfinger et al., 2006
Shanks are scaffolding proteins that interact with many synaptic proteins in the postsynaptic density.
“Shanks are scaffolding proteins that interact with many synaptic proteins in the PSD (Ehlers, 1999; Gundelfinger et al., 2006; Kreienkamp, 2008; Sheng and Kim, 2000).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Gundelfinger et al., 2006
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- Authors
- Gundelfinger, E. D., Boeckers, T. M., Baron, M. K., & Bowie, J. U.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- Universität Ulm (DE)
- University of California, Los Angeles (US)
- Corresponding author
- Gundelfinger, Eckart D.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 31
- Issue
- 7
- Pages
- 366-373
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1998829215
- Cited by
- 98
- References
- 55
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA081000)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- zinc, postsynaptic density, SHANK3, SAM domain, scaffold proteins, synaptic plasticity, chemical synapses, zinc influx, glutamate release
- MeSH terms
- Animals, Models, Neurological, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Synapses, Zinc, Signal Transduction, Protein Structure, Secondary, Protein Structure, Tertiary, Adaptor Proteins, Signal Transducing, Rats
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