Impact of dose on the bioavailability of coffee chlorogenic acids in humans

Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works

Hierarchical Scheme for LC-MSn Identification of Chlorogenic Acids

Clifford, M. N., Johnston, K. L., Knight, S., & Kuhnert, N. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf026187q · Cited by 1,264 · see citing works

Discriminating between the Six Isomers of Dicaffeoylquinic Acid by LC-MSn

Clifford, M. N., Knight, S., & Kuhnert, N. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050046h · Cited by 691 · see citing works

Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans

Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S. (2008) · The Journal of Nutrition · doi:10.3945/jn.108.095554 · Cited by 578 · see citing works

Bioavailability of dietary flavonoids and phenolic compounds

Crozier, A., Rio, D. D., & Clifford, M. N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.007 · Cited by 550 · see citing works

Effect of Roasting on the Formation of Chlorogenic Acid Lactones in Coffee

Farah, A., de Paulis, T., Trugo, L. C., & Martin, P. R. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048701t · Cited by 540 · see citing works

Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

Spencer, J. P. E., Mohsen, M. M. A. E., Minihane, A.-M., & Mathers, J. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507798938 · Cited by 490 · see citing works

Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin

Day, A. J., Mellon, F. A., Barron, D., Sarrazin, G., Morgan, M. R. A., & Williamson, G. (2001) · Free Radical Research · doi:10.1080/10715760100301441 · Cited by 472 · see citing works

Colonic metabolites of berry polyphenols: the missing link to biological activity?

Williamson, G., & Clifford, M. N. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003946 · Cited by 463 · see citing works

Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption

Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G., & Crozier, A. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.028019 · Cited by 401 · see citing works

Absorption of Phenolic Acids in Humans after Coffee Consumption

Nardini, M., Cirillo, E., Natella, F., & Scaccini, C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0257547 · Cited by 386 · see citing works

Chlorogenic Acid Compounds from Coffee Are Differentially Absorbed and Metabolized in Humans ,

Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., & Donangelo, C. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2196 · Cited by 324 · see citing works

Esterase Activity Able To Hydrolyze Dietary Antioxidant Hydroxycinnamates Is Distributed along the Intestine of Mammals

Andreasen, M. F., Kroon, P. A., Williamson, G., & García‐Conesa, M. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010668c · Cited by 298 · see citing works

Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy

Stalmach, A., Steiling, H., Williamson, G., & Crozier, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.03.005 · Cited by 284 · see citing works

Novel biomarkers of the metabolism of caffeic acid derivatives in vivo

Rechner, A. R., Spencer, J. P. E., Kuhnle, G., Hahn, U., & Rice-Evans, C. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00506-8 · Cited by 255 · see citing works

Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers

Izukawa, T., Nakajima, M., Fujiwara, R., Yamanaka, H., Fukami, T., Takamiya, M., Aoki, Y., Ikushiro, S., Sakaki, T., & Yokoi, T. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.027227 · Cited by 231 · see citing works

The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man

Jaganath, I. B., Jaganath, I. B., Mullen, W., Edwards, C. A., & Crozier, A. (2006) · Free Radical Research · doi:10.1080/10715760600771400 · Cited by 208 · see citing works

Espresso coffees, caffeine and chlorogenic acid intake: potential health implications

Crozier, T. W. M., Stalmach, A., Lean, M. E. J., & Crozier, A. (2011) · Food & Function · doi:10.1039/c1fo10240k · Cited by 188 · see citing works

Catabolism of coffee chlorogenic acids by human colonic microbiota

Ludwig, I. A., Peña, M.-P. D., Cid, C., & Crozier, A. (2013) · BioFactors · doi:10.1002/biof.1124 · Cited by 176 · see citing works

Transport and Metabolism of Ferulic Acid through the Colonic Epithelium

Poquet, L., Clifford, M. N., & Williamson, G. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.017558 · Cited by 172 · see citing works

Characterization of Metabolites of Hydroxycinnamates in the in Vitro Model of Human Small Intestinal Epithelium Caco-2 Cells

Kern, S. M., Bennett, R. N., Needs, P. W., Mellon, F. A., Kroon, P. A., & García‐Conesa, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030470n · Cited by 147 · see citing works

Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers

Farrell, T. L., Dew, T. P., Poquet, L., Hanson, P. J., & Williamson, G. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.040147 · Cited by 78 · see citing works

Dose‐dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists

Erk, T., Williamson, G., Renouf, M., Marmet, C., Steiling, H., Dionisi, F., Barron, D., Melcher, R., & Richling, E. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200222 · Cited by 74 · see citing works

Dose–response plasma appearance of coffee chlorogenic and phenolic acids in adults

Renouf, M., Marmet, C., Giuffrida, F., Lepage, M., Barron, D., Beaumont, M., Williamson, G., & Dionisi, F. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300349 · Cited by 69 · see citing works

InVivo Release of 14C-Labelled Phenolic Groups from Intact Dietary Spinach Cell Walls During Passage Through the Rat Intestine

Buchanan, C. J., Wallace, G., Fry, S. C., & Eastwood, M. A. (1996) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(199608)71:4 · Cited by 65 · see citing works

First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption

Fumeaux, R., Menozzi, C., Stalmach, A., Munari, C., Kraehenbuehl, K., Steiling, H., Crozier, A., Williamson, G., & Barron, D. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00137f · Cited by 62 · see citing works

Biomarkers of dietary intake of flavonoids and phenolic acids for studying diet–cancer relationship in humans

Linseisen, J., & Rohrmann, S. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2007-x · Cited by 51 · see citing works

Teas, cocoa, and coffee: plant secondary metabolites and health

(2012) · Choice Reviews Online · doi:10.5860/choice.49-5098 · Cited by 48 · see citing works

Absorption and isomerization of caffeoylquinic acids from different foods using ileostomist volunteers

Erk, T., Renouf, M., Williamson, G., Melcher, R., Steiling, H., & Richling, E. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0512-z · Cited by 28 · see citing works

A systematic study of carboxylic acids in negative ion mode electrospray ionisation mass spectrometry providing a structural model for ion suppression

Clifford, M. N., López, V., Poquet, L., Williamson, G., & Kuhnert, N. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3038 · Cited by 18 · see citing works

Untitled work

Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7

Interactions of polyphenols with carbohydrates, lipids and proteins

Jakobek, L. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.12.013 · Cited by 1,236 · see citing works

Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions

Liang, N., & Kitts, D. D. (2015) · Nutrients · doi:10.3390/nu8010016 · Cited by 824 · see citing works

Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects

Smeriglio, A., Barreca, D., Bellocco, E., & Trombetta, D. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13630 · Cited by 692 · see citing works

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 608 · see citing works

Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity

Clifford, M. N., Jaganath, I. B., Ludwig, I. A., & Crozier, A. (2017) · Natural Product Reports · doi:10.1039/c7np00030h · Cited by 418 · see citing works

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson, G., & Clifford, M. N. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.012 · Cited by 346 · see citing works

Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

Sova, M., & Saso, L. (2020) · Nutrients · doi:10.3390/nu12082190 · Cited by 275 · see citing works

Fruits of Black Chokeberry Aronia melanocarpa in the Prevention of Chronic Diseases

Jurí­ková, T., Mlček, J., Škrovánková, S., Sumczynski, D., Sochor, J., Hlaváčová, I., Snopek, L., & Orsavová, J. (2017) · Molecules · doi:10.3390/molecules22060944 · Cited by 247 · see citing works

Bioavailability and metabolism of chlorogenic acids (acyl‐quinic acids) in humans

Clifford, M. N., Kerimi, A., & Williamson, G. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12518 · Cited by 183 · see citing works

Consumption of Chlorogenic Acids through Coffee and Health Implications

Farah, A., & Lima, J. D. P. (2019) · Beverages · doi:10.3390/beverages5010011 · Cited by 177 · see citing works

Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine

Nabavi, S. F., Tejada, S., Setzer, W. N., Gortzi, O., Sureda, A., Braidy, N., Daglia, M., Manayi, A., & Nabavi, S. M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160325120625 · Cited by 152 · see citing works

Hydroxycinnamic acids and human health: recent advances

Coman, V., & Vodnar, D. C. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10010 · Cited by 155 · see citing works

Chokeberries ( Aronia melanocarpa ) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

Borowska, S., & Brzoska, M. M. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12221 · Cited by 134 · see citing works

The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota

Scarano, A., Laddomada, B., Blando, F., Santis, S. D., Verna, G., Chieppa, M., & Santino, A. (2023) · Antioxidants · doi:10.3390/antiox12030630 · Cited by 130 · see citing works

Impact of potato processing on nutrients, phytochemicals, and human health

Furrer, A., Chegeni, M., & Ferruzzi, M. G. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1139542 · Cited by 131 · see citing works

Polyphenols and Their Interactions With Other Dietary Compounds: Implications for Human Health

Kardum, N., & Glibetić, M. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.12.001 · Cited by 124 · see citing works

Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics

Li, L., Su, C., Chen, X., Wang, Q., Jiao, W., Luo, H., Tang, J., Wang, W., Li, S., & Guo, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01554 · Cited by 124 · see citing works

Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial.

Agudelo-Ochoa, G. M., Pulgarín-Zapata, I. C., Velásquez-Rodriguez, C. M., Duque-Ramı́rez, M., Naranjo-Cano, M., Quintero-Ortiz, M. M., Lara-Guzmán, Ó., & Muñoz-Durango, K. (2016) · Journal of NutriLife · doi:10.3945/jn.115.224774 · Cited by 105 · see citing works

Nutritional Metabolomics and the Classification of Dietary Biomarker Candidates: A Critical Review

Rafiq, T., Azab, S. M., Teo, K. K., Thabane, L., Anand, S. S., Morrison, K. M., de Souza, R. J., & Britz‐McKibbin, P. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab054 · Cited by 105 · see citing works

Wheat bread enriched with green coffee – In vitro bioaccessibility and bioavailability of phenolics and antioxidant activity

Świeca, M., Gawlik‐Dziki, U., Dziki, D., & Baraniak, B. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.11.006 · Cited by 100 · see citing works

Absorption and metabolism of yerba mate phenolic compounds in humans

Gómez‐Juaristi, M., Martínez‐López, S., Sarriá, B., Bravo, L., & Mateos, R. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.08.003 · Cited by 96 · see citing works

The Acute Effects of Caffeinated Black Coffee on Cognition and Mood in Healthy Young and Older Adults

Haskell‐Ramsay, C. F., Jackson, P. A., Forster, J. S., Dodd, F. L., Bowerbank, S. L., & Kennedy, D. O. (2018) · Nutrients · doi:10.3390/nu10101386 · Cited by 97 · see citing works

Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes

Mena, P. R., Ludwig, I. A., Tomatis, V., Acharjee, A., Calani, L., Rosi, A., Brighenti, F., Ray, S., Griffin, J. L., Bluck, L. J. C., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1683-4 · Cited by 93 · see citing works

In vitro colonic catabolism of orange juice (poly)phenols

Pereira‐Caro, G., Borges, G., Ky, I., Ribas‐Latre, A., Calani, L., Rio, D. D., Clifford, M. N., Roberts, S. A., & Crozier, A. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400779 · Cited by 90 · see citing works

Ground green coffee beans as a functional food supplement – Preliminary study

Dziki, D., Gawlik‐Dziki, U., Pecio, Ł., Różyło, R., Świeca, M., Krzykowski, A., & Rudy, S. (2015) · LWT · doi:10.1016/j.lwt.2015.03.076 · Cited by 90 · see citing works

The Impact of Coffee and Its Selected Bioactive Compounds on the Development and Progression of Colorectal Cancer In Vivo and In Vitro

Bułdak, R. J., Hejmo, T., Osowski, M., Bułdak, Ł., Kukla, M., Polaniak, R., & Birkner, E. (2018) · Molecules · doi:10.3390/molecules23123309 · Cited by 89 · see citing works

Hydroxycinnamic acids on gut microbiota and health

Leonard, W., Zhang, P., Ying, D., & Fang, Z. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12663 · Cited by 89 · see citing works

Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile in Plasma over 24‐h Period in Human Subjects

Zhong, S., Sandhu, A. K., Edirisinghe, I., & Burton‐Freeman, B. M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700405 · Cited by 86 · see citing works

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

Keane, K. M., Bell, P. G., Lodge, J. K., Constantinou, C. L., Jenkinson, S. E., Bass, R., & Howatson, G. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0988-9 · Cited by 83 · see citing works

Biomarkers of intake for coffee, tea, and sweetened beverages

Rothwell, J. A., Madrid-Gambín, F., Garcia‐Aloy, M., Andrés‐Lacueva, C., Logue, C., Gallagher, A. M., Mack, C. I., Kulling, S. E., Gao, Q., Praticò, G., et al. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0607-5 · Cited by 79 · see citing works

Hydrothermal synthesis of carbon dots and their application for detection of chlorogenic acid

Zhu, H., Li, H., Pan, S., Liu, H., & Hu, X. (2020) · Luminescence · doi:10.1002/bio.3803 · Cited by 76 · see citing works

Bioavailability of hydroxycinnamates in an instant green/roasted coffee blend in humans. Identification of novel colonic metabolites

Gómez‐Juaristi, M., Martínez‐López, S., Sarriá, B., Bravo, L., & Mateos, R. (2017) · Food & Function · doi:10.1039/c7fo01553d · Cited by 73 · see citing works

Carbohydrate content, dietary fibre and melanoidins: Composition of espresso from single-dose coffee capsules

Lopes, G. R., Ferreira, A. S., Pinto, M., Passos, C. P., Coelho, E., Rodrigues, C., Figueira, C., Rocha, S. M., Nunes, F. M., & Coimbra, M. A. (2016) · Food Research International · doi:10.1016/j.foodres.2016.01.018 · Cited by 68 · see citing works

The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors

Baeza, G., Bachmair, E., Wood, S. G., Mateos, R., Bravo, L., & de Roos, B. (2017) · Food & Function · doi:10.1039/c6fo01404f · Cited by 66 · see citing works

Bioavailability of tomato polyphenols is enhanced by processing and fat addition: Evidence from a randomized feeding trial

Martínez‐Huélamo, M., Vallverdú‐Queralt, A., Lecce, G. D., Valderas-Martínez, P., Tulipani, S., Jáuregui, O., Escribano‐Ferrer, E., Estruch, R., Illán, M., & Lamuela-Raventós, R. M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500820 · Cited by 64 · see citing works

In vitro digestion of the whole blackberry fruit: bioaccessibility, bioactive variation of active ingredients and impacts on human gut microbiota

Dou, Z., Chen, C., Huang, Q., & Fu, X. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131001 · Cited by 63 · see citing works

A look beyond dietary (poly)phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation

Carregosa, D., Pinto, C., Ávila‐Gálvez, M. Á., Bastos, P., Berry, D., & dos Santos, C. N. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13006 · Cited by 59 · see citing works

Aronia ( Aronia melanocarpa ) phenolics bioavailability in a combined in vitro digestion/Caco-2 cell model is structure and colon region dependent

Wu, T., Grootaert, C., Voorspoels, S., Jacobs, G., Pitart, J., Kamiloğlu, S., Possemiers, S., Heinonen, M., Kardum, N., Glibetić, M., et al. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.09.008 · Cited by 59 · see citing works

Insights on the Health Benefits of the Bioactive Compounds of Coffee Silverskin Extract

Fernandez-Gomez, B., Lezama, A., Amigo-Benavent, M., Ullate, M., Herrero, M., Martín, M. Á., Mesa, M. D., & del Castillo, M. D. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.001 · Cited by 58 · see citing works

5-Caffeoylquinic Acid Ameliorates Cognitive Decline and Reduces Aβ Deposition by Modulating Aβ Clearance Pathways in APP/PS2 Transgenic Mice

Ishida, K., Misawa, K., Nishimura, H., Hirata, T., Yamamoto, M., & Ota, N. (2020) · Nutrients · doi:10.3390/nu12020494 · Cited by 53 · see citing works

A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries

Rothwell, J. A., Keski‐Rahkonen, P., Robinot, N. R., Assi, N., Casagrande, C., Jenab, M., Ferrari, P., Boutron‐Ruault, M., Mahamat‐Saleh, Y., Mancini, F. R., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900659 · Cited by 47 · see citing works

Healthy components of coffee processing by-products

Dorsey, B. M., & Jones, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811290-8.00002-5 · Cited by 51 · see citing works

In vitrostudies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds

Monente, C., Ludwig, I. A., Stalmach, A., Peña, M.-P. D., Cid, C., & Crozier, A. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1064874 · Cited by 42 · see citing works

Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential

Zalewska, K., Kulawik, M., Gierszewska, J., Gramala, Z., Kalus, O., Karpiński, M., Maćkowiak, J., Staniewski, A., Szymańska, Z., Zalewska, B., et al. (2025) · Nutrients · doi:10.3390/nu17203303 · Cited by 39 · see citing works

Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments

Wang, H., Zheng, S. H. E. N., Qing, L. I. U., Hou, X., Cao, Y. K., Liu, D., Jiang, H., & Du, H. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)60029-2 · Cited by 39 · see citing works

From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects

Domínguez‐López, I., López‐Yerena, A., Vallverdú‐Queralt, A., Pallàs, M., Lamuela-Raventós, R. M., & Pérez, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae034 · Cited by 42 · see citing works

Chlorogenic acid from coffee beans: evaluating the evidence for a blood pressure–regulating health claim

Loader, T. B., Taylor, C. G., Zahradka, P. C., & Jones, P. J. H. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw057 · Cited by 37 · see citing works

Bioavailability of the ferulic acid-derived phenolic compounds of a rice bran enzymatic extract and their activity against superoxide production

Pérez‐Ternero, C., Macià, A., de Sotomayor, M. Á., Parrado, J., Motilva, M.-J., & Herrera, M. D. (2017) · Food & Function · doi:10.1039/c7fo00243b · Cited by 37 · see citing works

Typical ultraviolet spectra in combination with diagnostic mass fragmentation analysis for the rapid and comprehensive profiling of chlorogenic acids in the buds of Lonicera macranthoides

Zhang, S., Hu, X., Shi, S.-Y., Huang, L., Chen, W., Chen, L., & Cai, P. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9450-y · Cited by 36 · see citing works

Coffee consumption and risk of gastric cancer: an updated meta-analysis.

(2016) · PubMed · doi:10.6133/apjcn.092015.07 · Cited by 35 · see citing works

In vivo study of the bioavailability and metabolic profile of (poly)phenols after sous-vide artichoke consumption

Domínguez-Fernández, M., Yang, P. Y. T., Ludwig, I. A., Clifford, M. N., Cid, C., & Rodriguez‐Mateos, A. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130620 · Cited by 35 · see citing works

GC/MS method to quantify bioavailable phenolic compounds and antioxidant capacity determination of plasma after acute coffee consumption in human volunteers

Lara-Guzmán, O. J., Álvarez, R., Osorio, E., Naranjo, M., & Muñoz-Durango, K. (2016) · Food Research International · doi:10.1016/j.foodres.2016.07.020 · Cited by 34 · see citing works

Availability and dose response of phytophenols from a wheat bran rich cereal product in healthy human volunteers

Neacsu, M., McMonagle, J., Fletcher, R. J., Hulshof, T., Duncan, S. H., Scobbie, L., Duncan, G., Cantlay, L. L., Horgan, G. W., de Roos, B., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600202 · Cited by 33 · see citing works

A dynamic view on the chemical composition and bioactive properties of mulberry fruit using an in vitro digestion and fermentation model

Dou, Z., Chen, C., Fu, X., & Liu, R. (2022) · Food & Function · doi:10.1039/d1fo03505c · Cited by 31 · see citing works

Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid

de Oliveira, D. M., Sampaio, G. R., Pinto, C. B., Catharino, R. R., & Bastos, D. H. M. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1290-1 · Cited by 29 · see citing works

New insights into antioxidant activity of Prunus spinosa flowers: Extracts, model polyphenols and their phenolic metabolites in plasma towards multiple in vivo-relevant oxidants

Marchelak, A., Owczarek, A., Rutkowska, M., Michel, P., Kołodziejczyk-Czepas, J., Nowak, P., & Olszewska, M. A. (2019) · Phytochemistry Letters · doi:10.1016/j.phytol.2019.02.011 · Cited by 29 · see citing works

Safety Pharmacological Evaluation of the Coffee Component, Caffeoylquinic Acid, and Its Metabolites, Using Ex Vivo and In Vitro Profiling Assays

Amano, Y., Honda, H., Nukada, Y., Ikeda, N., Yamane, M., Nakano, K., Kameyama, A., & Morita, O. (2019) · Pharmaceuticals · doi:10.3390/ph12030110 · Cited by 26 · see citing works

Coffee in cancer chemoprevention: an updated review

Ismail, T., Zeppa, S. D., Akhtar, S., Turrini, E., Layla, A., Sestili, P., & Fimognari, C. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1839412 · Cited by 26 · see citing works

Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short‐term repeated uptake intervention study

Bakuradze, T., Lang, R., Hofmann, T. F., Schipp, D., Galan, J., Eisenbrand, G., & Richling, E. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500668 · Cited by 26 · see citing works

Daily Intake of Chlorogenic Acids from Consumption of Maté (Ilex paraguariensis A.St.-Hil.) Traditional Beverages

Gebara, K. S., Gasparotto, A., Santiago, P. G., Cardoso, C. A. L., de Souza, L. M., Morand, C., Costa, T. A., & Cardozo, E. L. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04093 · Cited by 25 · see citing works

Effect of different patterns of consumption of coffee and a cocoa-based product containing coffee on the nutrikinetics and urinary excretion of phenolic compounds

Mena, P. R., Bresciani, L., Tassotti, M., Rosi, A., Martini, D., Antonini, M., Dei, A., Bonadonna, R. C., Brighenti, F., & Rio, D. D. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab299 · Cited by 25 · see citing works

A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids

Pede, G. D., Mena, P. R., Bresciani, L., Achour, M., Lamuela-Raventós, R. M., Estruch, R., Landberg, R., Kulling, S. E., Wishart, D. S., Rodriguez‐Mateos, A., et al. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0254 · Cited by 24 · see citing works

Chlorogenic acid and intestinal health: mechanistic insights and therapeutic applications

Xu, J., Zhao, X., Yang, S., Tang, M., Zhao, R., & Hu, S. (2025) · Food & Function · doi:10.1039/d5fo00853k · Cited by 23 · see citing works

Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae

Tang, Y., Yin, L., Zhang, Y., Huang, X., Zhao, F., Cui, X., Shi, L., & Xu, L. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.016 · Cited by 23 · see citing works

Fabrication and characterization of TPGS-modified chlorogenic acid liposomes and its bioavailability in rats

Zhang, J., Luo, Q., Li, Q.-Q., Xu, Q. Y., Geng, X., & Xiong, J. (2024) · RSC Advances · doi:10.1039/d4ra04116j · Cited by 22 · see citing works

Oxylipin regulation by phenolic compounds from coffee beverage: Positive outcomes from a randomized controlled trial in healthy adults and macrophage derived foam cells

Lara-Guzmán, O. J., Medina, S., Álvarez, R., Oger, C., Durand, T., Galano, J., Zuluaga, N., Gil‐Izquierdo, Á., & Muñoz-Durango, K. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.020 · Cited by 22 · see citing works

A critical examination of human data for the biological activity of phenolic acids and their phase-2 conjugates derived from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

Williamson, G., & Clifford, M. N. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2410874 · Cited by 22 · see citing works

Bioassay‐Based Isolation and Identification of Phenolics from Sweet Cherry That Promote Active Glucose Consumption by HepG2 Cells

Cao, J., Li, X., Liu, Y., Leng, F., Li, X., Sun, C., & Chen, K. (2015) · Journal of Food Science · doi:10.1111/1750-3841.12743 · Cited by 20 · see citing works

Effect of simultaneous consumption of soymilk and coffee on the urinary excretion of isoflavones, chlorogenic acids and metabolites in healthy adults

Felberg, I., Farah, A., Monteiro, M. C., Godoy, R. L. D. O., Pacheco, S., Calado, V. M. D. A., & Donangelo, C. M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.059 · Cited by 20 · see citing works

Unravelling phenolic metabotypes in the frame of the COMBAT study, a randomized, controlled trial with cranberry supplementation

Tosi, N., Favari, C., Bresciani, L., Flanagan, E. C., Hornberger, M., Narbad, A., Rio, D. D., Vauzour, D., & Mena, P. R. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113187 · Cited by 20 · see citing works

Sensitive and Rapid UHPLC-MS/MS for the Analysis of Tomato Phenolics in Human Biological Samples

Martínez‐Huélamo, M., Tulipani, S., Jáuregui, O., Valderas-Martínez, P., Vallverdú‐Queralt, A., Estruch, R., Torrado, X., & Lamuela-Raventós, R. M. (2015) · Molecules · doi:10.3390/molecules201119702 · Cited by 19 · see citing works

Metabolism of phenolics in coffee and plant-based foods by canonical pathways: an assessment of the role of fatty acid β-oxidation to generate biologically-active and -inactive intermediates

Clifford, M. N., King, L. J., Kerimi, A., Pereira‐Caro, G., & Williamson, G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2131730 · Cited by 18 · see citing works

In Silico Design of Short Peptides as Sensing Elements for Phenolic Compounds

Carlo, M. D., Capoferri, D., Gladich, I., Guida, F., Forzato, C., Navarini, L., Compagnone, D., Laio, A., & Berti, F. (2016) · ACS Sensors · doi:10.1021/acssensors.5b00225 · Cited by 18 · see citing works

Coffee, type 2 diabetes and pancreatic islet function – A mini-review

Costabile, A., Sarnsamak, K., & Hauge-Evans, A. C. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.011 · Cited by 18 · see citing works

The colonic polyphenol catabolite dihydroferulic acid (DHFA) regulates macrophages activated by oxidized LDL, 7-ketocholesterol, and LPS switching from pro- to anti-inflammatory mediators

Lara-Guzmán, O. J., Arango-González, Á. M., Rivera, D. A., Muñoz-Durango, K., & Sierra, J. A. (2024) · Food & Function · doi:10.1039/d4fo02114b · Cited by 16 · see citing works

Soybean oil and coconut oil enhance the absorption of chlorogenic acid in humans

Weerakoon, T., Anjali, N. V. P., Jayathilaka, N., & Seneviratne, K. N. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13823 · Cited by 16 · see citing works

The Effects of Prunus spinosa L. Flower Extracts, Model Polyphenols and Phenolic Metabolites on Oxidative/Nitrative Modifications of Human Plasma Components with Particular Emphasis on Fibrinogen In Vitro

Marchelak, A., Kołodziejczyk-Czepas, J., Wasielewska, P., Nowak, P., & Olszewska, M. A. (2021) · Antioxidants · doi:10.3390/antiox10040581 · Cited by 14 · see citing works

Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects

Seguido, M. Á., Tarradas, R. M., González-Rámila, S., García-Cordero, J., Sarriá, B., Bravo, L., & Mateos, R. (2022) · Nutrients · doi:10.3390/nu14122445 · Cited by 14 · see citing works

The roasting process does not influence the extent of conjugation of coffee chlorogenic and phenolic acids

Sanchez‐Bridge, B., Renouf, M., Sauser, J., Beaumont, M., & Actis‐Goretta, L. (2016) · BioFactors · doi:10.1002/biof.1268 · Cited by 14 · see citing works

Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling

Kawabata, T., Tokuda, H., Sakai, G., Fujita, K., Matsushima‐Nishiwaki, R., Otsuka, T., & Kozawa, O. (2018) · Biomedical Reports · doi:10.3892/br.2018.1140 · Cited by 14 · see citing works

Anti-Inflammatory Activity of Chlorogenic Acid on Macrophages: A Simplified Simulation of Pharmacokinetics Following Ingestion Using a Windup Syringe Pump

Cao, L., Han, W., Lee, S. G., & Shin, J. H. (2023) · Applied Sciences · doi:10.3390/app13010627 · Cited by 13 · see citing works

Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches

Mikropoulou, E. V., Basdeki, A., & Halabalaki, M. (2025) · Natural Product Reports · doi:10.1039/d5np00022j · Cited by 12 · see citing works

Antioxidant Activity of Sulfate Metabolites of Chlorogenic Acid

Rogozinska, M., Lisiecki, K., Czarnocki, Z., & Biesaga, M. (2023) · Applied Sciences · doi:10.3390/app13042192 · Cited by 12 · see citing works

Consumption of Plant-Derived Phenolic Acids Modulates Hunger and Satiety Responses Due to Chemical Interactions with Enteroendocrine Mediators

Zuñiga-Martínez, B. S., Domínguez-Avila, J. A., Montiel‐Herrera, M., Villegas‐Ochoa, M. A., Robles-Sánchez, R. M., Ayala-Zavala, J. F., Viuda‐Martos, M., & González-Aguilar, G. A. (2024) · Foods · doi:10.3390/foods13223640 · Cited by 11 · see citing works

The magical smell and taste: Can coffee be good to patients with cardiometabolic disease?

Ribeiro, M. M., Alvarenga, L., Cardozo, L., Kemp, J. A., Lima, L. S., de Almeida, J. S., Leal, V. D. O., Stenvinkel, P., Shiels, P. G., & Mafra, D. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106938 · Cited by 13 · see citing works

Daily consumption of a dark-roast coffee for eight weeks improved plasma oxidized LDL and alpha-tocopherol status: A randomized, controlled human intervention study

Hochkogler, C. M., Schweiger, K., Rust, P., Pignitter, M., Rathmayr, J., Bayer, S., Chmelirsch, C., Hüller, L., Marko, D., Lang, R., et al. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.009 · Cited by 10 · see citing works

Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention

Hsieh, W.-Y., Yu, C., Chen, C. C., Chiou, C., Green, B. D., Lee, O. K., Wu, C.-C., Doan, L. H., Huang, C. F., Huang, C. Y., et al. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.11.009 · Cited by 9 · see citing works

Study of the Antioxidant Effects of Coffee Phenolic Metabolites on C6 Glioma Cells Exposed to Diesel Exhaust Particles

Botto, L., Bulbarelli, A., Lonati, E., Cazzaniga, E., Tassotti, M., Mena, P. R., Rio, D. D., & Palestini, P. (2021) · Antioxidants · doi:10.3390/antiox10081169 · Cited by 8 · see citing works

Fermentation of Plant-Based Yogurt and Its Effects on Phytochemicals: A Review

Xu, X., Wang, G., Xie, F., Song, X., Zhang, H., Xiong, Z., Ai, L., & Xia, Y. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2502867 · Cited by 7 · see citing works

Acute Cognitive Performance and Mood Effects of Coffeeberry Extract: A Randomized, Double Blind, Placebo-Controlled Crossover Study in Healthy Humans

Jackson, P. A., Kenney, C., Forster, J. S., Smith, E., Elcoate, R., Spittlehouse, B., Johnson, J., & Kennedy, D. O. (2023) · Nutrients · doi:10.3390/nu15112418 · Cited by 7 · see citing works

Variation in the Methylation of Caffeoylquinic Acids and Urinary Excretion of 3′‐methoxycinnamic acid‐4′‐Sulfate After Apple Consumption by Volunteers

Rubió, L., Romero, M., Solà, R., Motilva, M., Clifford, M. N., & Macià, A. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100471 · Cited by 7 · see citing works

Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder

Kaneda, T., Sasaki, N., URAKAWA, N., & Shimizu, K. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.12.006 · Cited by 7 · see citing works

Coffee and Coffee By-Products as Multifunctional Foods and Ingredients

Nemzer, B. V., Al-Taher, F., Abshiru, N. A., & de Mejı́a, E. G. (2025) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-052924-114847 · Cited by 6 · see citing works

Lipid Digestion and Bioaccessibility of Lipid-Soluble Compounds

Rashidinejad, A., Marze, S., & Singh, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-56909-9_10 · Cited by 5 · see citing works

Chlorogenic Acid: An In‐Depth Review of Its Effectiveness in Cancer Treatment

Wang, B., Yin, N., Liu, X., Yang, B., Cao, Y., Wang, Z., Bai, S., Zhang, S., Li, W., & Wang, Y. (2025) · Cancer Nexus · doi:10.1002/cnx2.70002 · Cited by 4 · see citing works

Effects of Coffee-Related Bioactive Components on Flow-Mediated Vasodilation: A Meta-Analysis of Randomized, Controlled Intervention Studies in Adults

Nijssen, K. M. R., Mensink, R. P., & Joris, P. J. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf211 · Cited by 3 · see citing works

Coffee phytochemicals and their protective roles in hepatic and renal disorders: a review

Asmaey, M. A., & Kita, M. (2025) · Food & Function · doi:10.1039/d5fo03944d · Cited by 3 · see citing works

Determination of Antioxidant Biomarkers in Biological Fluids

Jeszka‐Skowron, M., Podgórski, T., & Czarczyńska-Goślińska, B. (2021) · Food bioactive ingredients · doi:10.1007/978-3-030-61879-7_11 · Cited by 3 · see citing works

Hydroxycinnamates

Ludwig, I. A., Rubió, L., Macià, A., & Romero, M. (2020) · doi:10.1002/9781119563754.ch4 · Cited by 3 · see citing works

Chlorogenic Acid as a Modulator of Adipose Tissue Function and Metabolic Homeostasis: Evidence from Preclinical Studies

Sehra, A., & Tsiani, E. (2026) · Nutrients · doi:10.3390/nu18142358 · Cited by 2 · see citing works

Dose response bioavailability of coffee chlorogenic acids in humans

Renouf, M., Marmet, C., Giuffrida, F., Williamson, G., & Dionisi, F. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.124.6

Bioavailability and metabolism of coffee chlorogenic acids in humans

Renouf, M., Marmet, C., Giuffrida, F., Williamson, G., & Dionisi, F. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.234.3 · Cited by 2 · see citing works

Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption

Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G., & Crozier, A. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.028019 · Cited by 401 · see citing works

Chlorogenic Acid Compounds from Coffee Are Differentially Absorbed and Metabolized in Humans ,

Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., & Donangelo, C. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2196 · Cited by 324 · see citing works

Dose–response plasma appearance of coffee chlorogenic and phenolic acids in adults

Renouf, M., Marmet, C., Giuffrida, F., Lepage, M., Barron, D., Beaumont, M., Williamson, G., & Dionisi, F. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300349 · Cited by 69 · see citing works